[Paraneoplastic optic neuritis in an unknown small cell lung carcinoma defined by CRMP-5-IgG].

Abstract

CASE REPORT:

The case of a 64-year-old patient with bilateral, progressive and painless diminution of visual acuity is presented. Ophthalmologic evaluation revealed optic neuritis and vitreous cells in both eyes, at different stages. Suspecting a paraneoplastic optic neuritis, the study of antibodies was requested. This showed positivity to the marker CRMP-5-IgG. After mediastinoscopy, a small cell lung carcinoma was diagnosed.

DISCUSSION:

Autoantibody CRMP-5-IgG defines a paraneoplastic entity of combined optic neuritis and vitreous inflammatory cells. The serological positivity avoids the vitreous biopsy and expedites the search for cancer. In our case, it allowed the diagnosis a previously unidentified tumor.

• Authors: J A Toribio-García, M Franco-Benito, J M García-Ruiz-de-Morales
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 82 Issue 12 Pg. 777-80 (Dec 2007) ISSN: 0365-6691 [Print] Spain
• Vernacular Title: Neuritis óptica paraneoplásica en carcinoma microcítico pulmonar desconocido definida por marcador CRMP-5-IgG.
• PMID: 18040924 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Immunoglobulin G
• Microtubule-Associated Proteins
• Nerve Tissue Proteins
• DPYSL5 protein, human
• Hydrolases

Topics

• Autoantibodies (analysis)
• Carcinoma, Small Cell (complications)
• Humans
• Hydrolases
• Immunoglobulin G (analysis)
• Lung Neoplasms (complications)
• Male
• Microtubule-Associated Proteins
• Middle Aged
• Nerve Tissue Proteins (analysis)
• Optic Neuritis (diagnosis, etiology)
• Paraneoplastic Syndromes (diagnosis, etiology)