Abstract | BACKGROUND: METHODS: RESULTS: Compared to the pre-treatment baseline diet, all three strains of flax significantly reduced blood pressure during mental stress induced by a frustrating cognitive task (Stroop color-word interference task) (p = 0.004). Linola 989, the strain highest in lignan and lowest in alpha-linolenic acid, was associated with the least increase in peripheral resistance during stress, the greatest reduction in plasma cortisol during stress and the smallest increase in plasma fibrinogen during mental stress. CONCLUSION: Flax phytoestrogens ameliorate certain responses to stress and thus may afford protection against atherosclerosis; this hypothesis should be tested in clinical trials.
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Authors | J David Spence, Tanya Thornton, Alister D Muir, Neil D Westcott |
Journal | Journal of the American College of Nutrition
(J Am Coll Nutr)
Vol. 22
Issue 6
Pg. 494-501
(Dec 2003)
ISSN: 0731-5724 [Print] United States |
PMID | 14684754
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Lignans
- alpha-Linolenic Acid
- Fibrinogen
- Hydrocortisone
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Topics |
- Aged
- Biomarkers
(blood)
- Blood Pressure
(drug effects)
- Cardiac Output
(drug effects)
- Cross-Over Studies
- Double-Blind Method
- Female
- Fibrinogen
(drug effects, metabolism)
- Flax
- Humans
- Hydrocortisone
(metabolism)
- Lignans
(therapeutic use)
- Mental Fatigue
(drug therapy)
- Middle Aged
- Phytotherapy
(methods)
- Seeds
- Stress, Psychological
(drug therapy)
- Treatment Outcome
- Vascular Resistance
(drug effects)
- alpha-Linolenic Acid
(therapeutic use)
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