Abstract | PURPOSE: EXPERIMENTAL DESIGN: RESULTS: Cells were either growth inhibited and underwent apoptosis or were resistant to treatment with this compound. Retinoids have been shown to decrease the gene transcription rates of transforming growth factor ( TGF)-alpha and EGFR in HNSCC. LGD1550 responsiveness was accompanied by decreased expression of TGF-alpha, EGFR, and modulation of EGFR signaling pathways, including signal transducers and activators of transcriptions and mitogen-activated protein kinase. In contrast, EGFR autocrine signaling pathways were not altered in HNSCC cells that were resistant to the growth inhibitory effects of LGD1550. CONCLUSIONS: These results suggest that there is a correlation between the efficacy of receptor-selective retinoids and modulation of TGF-alpha/EGFR signaling in HNSCC. Therefore, alterations of these signaling pathways may serve as a biomarker of clinical response.
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Authors | Miriam Lango, Abbey L Wentzel, John I Song, Sichuan Xi, Daniel E Johnson, William W Lamph, Lori Miller, Jennifer Rubin Grandis |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 9
Issue 11
Pg. 4205-13
(Sep 15 2003)
ISSN: 1078-0432 [Print] United States |
PMID | 14519647
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anticarcinogenic Agents
- Fatty Acids, Unsaturated
- Receptors, Retinoic Acid
- Retinoids
- Tetrahydronaphthalenes
- octa-2,4,6-trienoic acid
- Bexarotene
- ErbB Receptors
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Topics |
- Animals
- Anticarcinogenic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Bexarotene
- Carcinoma, Squamous Cell
(pathology)
- Cell Division
(drug effects)
- Cell Line, Tumor
- ErbB Receptors
(physiology)
- Fatty Acids, Unsaturated
(pharmacology)
- Head and Neck Neoplasms
(pathology)
- Humans
- Receptors, Retinoic Acid
(drug effects, physiology)
- Retinoids
(pharmacology)
- Signal Transduction
(drug effects, physiology)
- Tetrahydronaphthalenes
(pharmacology)
- Transplantation, Heterologous
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