Treatment of recurrent chronic hyperplastic sinusitis with nasal polyposis.

Abstract

OBJECTIVE:

To demonstrate the long-term efficacy of intranasal furosemide, an inhibitor of the sodium chloride cotransporter channel at the basolateral surface of the respiratory epithelial cell, vs no therapeutic intervention vs intranasal mometasone furoate, a corticosteroid, in preventing relapses of chronic hyperplastic sinusitis with nasal polyposis.

DESIGN:

Randomized prospective controlled study. Patients were examined every 6 months during follow-up (range, 1-9 years).

PATIENTS:

One hundred seventy patients with bilateral obstructive or minimally obstructive chronic hyperplastic sinusitis with nasal polyposis.

INTERVENTION:

All patients were surgically treated in the ENT Department, University of Siena Medical School. One month after surgery, group 1 patients (n = 97) started treatment with intranasal furosemide, group 2 (n = 40) received no therapeutic treatment, and group 3 (n = 33) were treated with mometasone.

MAIN OUTCOME MEASURES:

Clinical and instrumental evaluation of postoperative outcomes.

RESULTS:

Seventeen (17.5%) of 97 patients in group 1, 12 (30.0%) of 40 patients in group 2, and 8 (24.2%) of 33 patients in group 3 experienced nasal polyposis relapses. We noted a prevalence of early-stage relapse in patients treated with furosemide or mometasone, whereas patients who did not receive any treatment experienced more severe grades of chronic hyperplastic sinusitis with nasal polyposis (P<.005).

CONCLUSION:

Use of intranasal furosemide represents a valid therapeutic treatment in the prevention of chronic hyperplastic sinusitis with nasal polyposis.

• Authors: Desiderio Passàli, Joel M Bernstein, Francesco Maria Passali, Valerio Damiani, Giulio Cesare Passàli, Luisa Bellussi
• Journal: Archives of otolaryngology--head & neck surgery (Arch Otolaryngol Head Neck Surg) Vol. 129 Issue 6 Pg. 656-9 (Jun 2003) ISSN: 0886-4470 [Print] United States
• PMID: 12810472 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Diuretics
• Pregnadienediols
• Sodium Chloride Symporters
• Symporters
• Mometasone Furoate
• Furosemide

Topics

• Administration, Intranasal
• Adult
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Chronic Disease
• Diuretics (administration & dosage, therapeutic use)
• Female
• Furosemide (administration & dosage, therapeutic use)
• Humans
• Hyperplasia
• Male
• Middle Aged
• Mometasone Furoate
• Nasal Obstruction (complications, drug therapy)
• Nasal Polyps (complications, drug therapy)
• Paranasal Sinuses (pathology)
• Pregnadienediols (administration & dosage, therapeutic use)
• Prospective Studies
• Secondary Prevention
• Sinusitis (complications, drug therapy, prevention & control)
• Sodium Chloride Symporters
• Symporters (antagonists & inhibitors)
• Treatment Outcome