Abstract | OBJECTIVE: METHODS: The cancer and para- cancer tissues were collected from 30 HCC patients. The mRNAs of seven CT antigens were detected by reverse transcription-polymerase chain reaction (RT-PCR) with the specific primers. The PCR products were sequenced to analyze the CT genes. RESULTS: The MAGE-1, MAGE-3, MAGE-4, MAGE-10, NY-ESO-1, SSX-2 and SCP-1 were expressed in 66.7%, 70.0%, 20.0%, 36.7%, 40.0%, 33.3% and 33.3% of the tumor tissues from HCC patients respectively, however, they were not expressed in the para- cancer tissues. Among the 30 patients investigated, 90.0% expressed one CT gene at least, 70.0% expressed two CT genes, and 53.3% expressed three CT genes of the seven CT genes. The coding genes of these CT antigens were highly conserved between in Chinese patients and patients abroad. There were discernible correlations between alpha-fetoprotein level and MAGE-10 or SCP-1 expression level, as well as between average age and MAGE-3 or SSX-2 expression levels (P<0.05). CONCLUSIONS: With a highly conserved coding gene, seven CT antigens were expressed in 20.0% - 70.0% of Chinese HCC patients. CT antigens' expression had correlations with some clinical characters.
|
Authors | Hong-song Chen, Liu-liang Qin, Xu Cong, Yu Wang, Ran Fei, Dong Jiang, Ji Cao, Jian-jia Su, Lai Wei, Wei-feng Chen, Yu Wang |
Journal | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
(Zhonghua Gan Zang Bing Za Zhi)
Vol. 11
Issue 3
Pg. 145-8
(Mar 2003)
ISSN: 1007-3418 [Print] China |
PMID | 12681059
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antigens, Neoplasm
- MAGEA1 protein, human
- MAGEA3 protein, human
- MAGEA4 protein, human
- Melanoma-Specific Antigens
- Neoplasm Proteins
- RNA, Messenger
|
Topics |
- Antigens, Neoplasm
(biosynthesis, genetics)
- Carcinoma, Hepatocellular
(genetics, immunology)
- Female
- Gene Expression Regulation, Neoplastic
(genetics)
- Humans
- Liver Neoplasms
(genetics, immunology)
- Male
- Melanoma-Specific Antigens
- Neoplasm Proteins
(biosynthesis, genetics)
- RNA, Messenger
(biosynthesis, genetics)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|