[Studies on the anticancer effect of howiinol A, a new compound isolated from Goniothalamus howii].

Abstract

The effect of howiinol A (GHM-10) on the growth of several cancer and normal cells were studied, using the methods of cell growth curve determination, MTT test and soft-agar colony formation assay. The results showed that GHM-10 exhibited potent inhibitory effect on cancer cells with an IC50 of 2 micrograms.ml-1 approximately. Normal cells, especially bone marrow progenitor cells, were shown to be less sensitive to GHM-10. A drug-resistant cell line, KB/VCR200, was found to be as sensitive as its parental KB cells. GHM-10 did not induce HL-60 cell differentiation. In murine transplantable tumors, GHM-10 was found to have significant therapeutic effect on mice bearing solid tumor hepatoma H22, Lewis lung carcinoma and S180 ascites.

• Authors: J He, Y Ye, C Xu
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 33 Issue 7 Pg. 493-7 (Jul 1998) ISSN: 0513-4870 [Print] China
• PMID: 12016881 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Pyrones
• howiinol A

Topics

• Animals
• Annonaceae (chemistry)
• Antineoplastic Agents, Phytogenic (isolation & purification, therapeutic use)
• Carcinoma, Lewis Lung (drug therapy)
• Female
• Humans
• KB Cells
• Liver Neoplasms, Experimental (drug therapy)
• Male
• Mice
• Mice, Inbred C57BL
• Neoplasm Transplantation
• Plant Bark (chemistry)
• Pyrones (isolation & purification, therapeutic use)
• Sarcoma 180 (drug therapy)