An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
Also Known As:
HB-EGF; Diphtheria Toxin Receptor; Diphtheria Toxin Receptors; HB-EGF Precursor; Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein; Receptor, Diphtheria Toxin; SF HB-EGF; Short Form HB-EGF; HB EGF; HB EGF Precursor; HB-EGF, Short Form; Heparin binding EGF like Growth Factor; Heparin binding Epidermal Growth Factor like Growth Factor Precursor Protein; Receptors, Diphtheria Toxin; SF HB EGF; Short Form HB EGF; Toxin Receptor, Diphtheria; Toxin Receptors, Diphtheria; Heparin-binding EGF-like Growth-Factor