Heparin-binding EGF-like Growth Factor (HB-EGF)

An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.

Also Known As:

HB-EGF; Diphtheria Toxin Receptor; Diphtheria Toxin Receptors; HB-EGF Precursor; Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein; Receptor, Diphtheria Toxin; SF HB-EGF; Short Form HB-EGF; HB EGF; HB EGF Precursor; HB-EGF, Short Form; Heparin binding EGF like Growth Factor; Heparin binding Epidermal Growth Factor like Growth Factor Precursor Protein; Receptors, Diphtheria Toxin; SF HB EGF; Short Form HB EGF; Toxin Receptor, Diphtheria; Toxin Receptors, Diphtheria; Heparin-binding EGF-like Growth-Factor

Networked: 692 relevant articles (26 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Besner, Gail E: 44 articles (09/2017 - 03/2002)
2.	Mekada, Eisuke: 30 articles (01/2022 - 05/2003)
3.	Miyamoto, Shingo: 29 articles (07/2018 - 08/2004)
4.	Higashiyama, Shigeki: 27 articles (01/2018 - 01/2001)
5.	Yotsumoto, Fusanori: 26 articles (07/2018 - 05/2006)
6.	Kuroki, Masahide: 18 articles (07/2018 - 11/2007)
7.	Iwamoto, Ryo: 13 articles (01/2017 - 01/2005)
8.	Miyata, Kohei: 11 articles (07/2018 - 07/2011)
9.	Yagi, Hiroshi: 11 articles (01/2017 - 08/2004)
10.	Chen, Chun-Liang: 11 articles (06/2014 - 04/2010)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2016 - "Specifically, targeted inhibition of HB-EGF improves the therapeutic efficacy and suppresses the tumor progression. " 02/01/2010 - "This study not only associates Tgf-α and Hb-egf expression with wild-type Egfr oncogenicity but also ascribes the proangiogenic activity of Egfr in this tumor model to a novel mesenchymal Hb-egf/Egfr signaling axis, whereby endothelial and pericyte-derived Hb-egf activates Egfr specifically in tumor-associated perivascular cells, leading to increased pericyte coverage of the tumor endothelium and enhanced angiogenesis." 01/01/2010 - "In the present study, we found that HB-EGF was expressed in host-derived cancer stromal cells in xenograft and allograft mouse tumor models. " 05/01/2006 - "Studies in vitro and in vivo have indicated that HB-EGF expression is essential for tumor formation of cancer-derived cell lines. " 08/01/2004 - "In vivo studies also demonstrated that tumor cells expressing s-HB-EGF or wild-type HB-EGF significantly enhanced tumorigenic potential in athymic nude mice and exerted an angiogenic effect, increasing the density and size of tumor blood vessels. "
2.	Ischemia 11/01/2005 - "Heparin-binding, EGF-like growth factor protected the intestine from injury when administered before injury and was also effective when administered during ischemia or even after injury. " 09/01/2010 - "In the current study, we investigated the ability of HB-EGF to protect the lungs from remote organ injury after intestinal ischemia/reperfusion (I/R). " 06/01/2008 - "The aim of the current study was to evaluate the effect of HB-EGF gene disruption on intestinal restitution, angiogenesis, and long-term survival after intestinal ischemia/reperfusion (I/R) injury. " 01/01/2013 - "New therapeutic agents targeting intestinal ischemia, like HB-EGF, are promising therapeutic agents for the treatment of NEC." 06/01/2008 - "Histologic damage after ischemia was significantly higher in HB-EGF (-/-) mice compared with HB-EGF (+/+) mice, associated with a significantly higher number of incompetent (nonhealed, nonresurfaced) villi indicative of delayed structural healing by restitution. "
3.	Ovarian Neoplasms (Ovarian Cancer) 07/01/2011 - "The aim of this study was to examine HB-EGF levels in the peritoneal fluid and serum of ovarian cancer (OVCA) patients. " 10/01/2023 - "HB-EGF mediates the progression of ovarian cancer and is associated with disease prognosis. " 01/01/2022 - "Although HB-EGF is involved in ovarian cancer progression, there is still no clarity about its relevance with PCOS. " 07/01/2018 - "To assess the clinical significance of serum HB-EGF in recurrent ovarian cancer, the association between serum HB-EGF levels and prognosis in patients with recurrent ovarian cancer was examined using ELISA. " 01/01/2017 - "We found that high serum HB-EGF concentrations were significantly associated with poor prognosis in a combined cohort of patients with all stages of ovarian cancer, as well as in a subset of patients with advanced disease. "
4.	Wounds and Injuries (Trauma) 11/01/2010 - "The wound closure was significantly impaired in HB(-/-) MCECs and was improved by adding HB-EGF. " 06/01/2005 - "Studies of wound healing revealed that wound closure was markedly impaired in keratinocyte-specific HB-EGF-deficient mice. " 05/22/2018 - "In a full thickness excisional wound model of a diabetic rat, the wound treated with the HB-EGF-loaded S-PLGA scaffold was basically healed after 28 days. " 02/01/2018 - "Wound closure (days 4-5 vs. day 6, p = 0.01) occurred earlier with HB-EGF. " 02/01/2018 - "Epithelial separation (59 vs. 100%, p = 0.003) and wound reopening (8 vs. 48%, p < 0.001) were reduced with HB-EGF. "
5.	Atherosclerosis 02/01/2013 - "Paracrine activity of heparin-binding EGF-like growth factor in atherogenesis: an immunohistochemical study." 03/30/2007 - "Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques." 10/01/2004 - "Taken together, HB-EGF can also act as an inducer of LOX-1 expression and play an integral role in foam cell transformation, cellular dysfunction, and proliferation of smooth muscle cells in atherogenesis." 05/01/2000 - "We previously reported that HB-EGF is involved in atherogenesis of human aorta and coronary arteries. " 12/01/1996 - "These data suggest that HB-EGF might play important roles in the migration of SMCs from the media to the intima, the proliferation of intimal SMCs, and the interaction between SMCs and macrophages in the process of coronary atherogenesis."

Related Drugs and Biologics

1.	Epidermal Growth Factor (EGF)
2.	Heparin (Liquaemin)
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	CRM197 (non-toxic variant of diphtheria toxin)
5.	Messenger RNA (mRNA)
6.	ErbB Receptors (EGF Receptor)
7.	Matrix Metalloproteinases (MMPs)
8.	Glucose (Dextrose)
9.	Galectin 1 (LGALS1)
10.	Neutralizing Antibodies

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Salvage Therapy
4.	Intraventricular Injections
5.	Resuscitation