Vitamin D3 24-Hydroxylase

A cytochrome P-450 enzyme that has specificity for CHOLECALCIFEROL (Vitamin D3). It hydroxylates the molecule at carbon position 24.

Also Known As:

1 alpha,25-Dihydroxycholecalciferol-24-Hydroxylase; 1 alpha,25-Dihydroxyvitamin D(3)-24-Hydroxylase; 1,25-Dihydroxyvitamin D3 24-Hydroxylase; 25-Hydroxycholecalciferol-24-Hydroxylase; CYP24A1; Calcitriol 24-Hydroxylase; Cytochrome P-450 CYP24A1; Vitamin D 24-Hydroxylase; 1 alpha,25 Dihydroxycholecalciferol 24 Hydroxylase; 1,25 Dihydroxyvitamin D3 24 Hydroxylase; 24-Hydroxylase, Vitamin D3; 25 Hydroxycholecalciferol 24 Hydroxylase; CYP24A1, Cytochrome P-450; Calcitriol 24 Hydroxylase; Cytochrome P 450 CYP24A1; D3 24-Hydroxylase, 1,25-Dihydroxyvitamin; P-450 CYP24A1, Cytochrome; Vitamin D 24 Hydroxylase; Vitamin D3 24 Hydroxylase; alpha,25-Dihydroxycholecalciferol-24-Hydroxylase, 1

Networked: 429 relevant articles (11 outcomes, 77 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jones, Glenville: 19 articles (01/2022 - 12/2004)
2.	Kaufmann, Martin: 14 articles (01/2022 - 08/2011)
3.	Sakaki, Toshiyuki: 8 articles (04/2022 - 05/2009)
4.	Slominski, Andrzej T: 8 articles (01/2022 - 10/2014)
5.	Peters, Ulrike: 8 articles (01/2020 - 10/2007)
6.	Konrad, Martin: 7 articles (01/2021 - 08/2011)
7.	Tuckey, Robert C: 6 articles (01/2022 - 12/2012)
8.	De Paolis, Elisa: 6 articles (04/2021 - 01/2017)
9.	Minucci, Angelo: 6 articles (04/2021 - 01/2017)
10.	Kittaka, Atsushi: 6 articles (01/2021 - 09/2009)

Related Diseases

1.	Neoplasms (Cancer) 09/05/2023 - "Therefore, we performed a comprehensive study to identify the association of CYP24A1 polymorphisms (rs4809960, rs6068816, rs2296241, rs4809957, rs2762939) with cancer susceptibility. " 12/16/2022 - "Relevant studies detecting the expression or SNP of CYP24A1 in cancer patients up till May 2022 were systematically searched in four common scientific databases including PubMed, EMBASE, Cochrane library and ISI Web of Science. " 12/01/2020 - "Therefore, the authors conducted this meta-analysis to more robustly assess relationships between CYP24A1 polymorphisms and the predisposition of cancer by pooling the findings of published studies. " 12/01/2020 - "CYP24A1 polymorphisms may affect predisposition of cancer, but the results of published studies remain inconclusive. " 01/01/2020 - "Previous studies proposed that rs2585428, rs4809960, rs6022999 and rs6068816 in CYP24A1 gene might be greatly associated with cancer risk. "
2.	Endometrial Neoplasms (Endometrial Cancer) 11/22/2016 - "Similarly, endometrial cancer cells expressed higher levels of CYP24A1 than immortalized endometrial epithelial cells. " 11/22/2016 - "siRNA-induced knockdown of CYP24A1 expression sensitized endometrial cancer cells to calcitriol-induced growth inhibition. " 11/22/2016 - "Progesterone potentiates the growth inhibitory effects of calcitriol in endometrial cancer via suppression of CYP24A1." 11/22/2016 - "These data suggest that CYP24A1 overexpression reduces the antitumor effects of calcitriol in cancer cells and that progestins may be beneficial for maintaining calcitriol's anti-endometrial cancer activity." 08/01/2019 - "We previously reported the chemopreventive and therapeutic efficacy of the combination of progestin and calcitriol in transformed and malignant endometrioid endometrial cancer (EC) and in ovarian cancer models involving attenuated expression of TGF-β signaling proteins and progestin-mediated inhibition of calcitriol-induced CYP24A1 expression. "
3.	Prostatic Neoplasms (Prostate Cancer) 07/04/2017 - "Thus, a CYP24A1 resistant VDR agonist may be beneficial for treatment of TMPRSS2:ERG positive prostate cancer; one negative consequence of TMPRSS2:ERG expression is inactivation of VDR signaling." 01/01/2020 - "The research on the CYP24A1 gene for prostate cancer is mainly concentrated in European and American populations, and there are few studies in the Chinese population. " 06/01/2014 - "The results of this study suggest that some CYP24A1 gene polymorphisms might be associated with the risk of prostate cancer in Korean men. " 06/01/2014 - "Genetic variants in the CYP24A1 gene are associated with prostate cancer risk and aggressiveness in a Korean study population." 01/01/2015 - "More genetic loci are needed to confirm the effect of CYP24A1 variation on the risk of prostate cancer."
4.	Hypercalcemia (Milk Alkali Syndrome) 01/01/2021 - "16 IH survivors in whom CYP24A1 (n = 13) or SLC34A1 (n = 3) variants were found and 41 subjects in whom hypercalcemia was diagnosed in the first year of life but in whom CYP24A1 or SLC34A1 variants were not found were included in the study. " 01/01/2016 - "This study (1) confirms that CYP24A1 plays a causal role in some but not all cases of IIH (64%); (2) expands the spectrum of known CYP24A1 pathogenic mutations; (3) describes 2 hotspots detected in 50% of all Italian cases; and (4) emphasizes the importance of recognition and genetic diagnosis of CYP24A1 defects in infantile as well as adult hypercalcemia." 12/01/2023 - "Case report: Non-PTH-dependent hypercalcemia in pregnancy: Consider CYP24A1 mutations." 11/27/2023 - "On December 8th, 2022, a systematic literature search was conducted in PubMed, Wanfang, and CNKI using the keywords "hypercalcemia" and "CYP24A1". " 09/01/2023 - "A new presentation of PTH-independent hypercalcemia found to be secondary to a CYP24A1 loss-of-function mutation in his sibling, Case 2, signaled the underlying cause. "
5.	Melanoma (Melanoma, Malignant) 10/20/2014 - "CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies." 01/01/2018 - "Unexpectedly, increased expression of CYP24A1 was associated with better melanoma prognosis. " 10/20/2014 - "With melanoma progression, CYP24A1 levels decreased and in advanced stages were comparable to the normal epidermis and metastases. " 10/20/2014 - "The statistically highest mean CYP24A1 level was found in nevi and early stage melanomas. " 01/01/2022 - "They acted on the vitamin D receptor (VDR) as demonstrated by image flow cytometry and the translocation of VDR coupled GFP from the cytoplasm to the nucleus of melanoma cells, as well as by the stimulation of CYP24A1 expression. "

Related Drugs and Biologics

1.	hydroxide ion
2.	1,25-dihydroxyvitamin D
3.	Calcitriol (Calcijex)
4.	Progestins (Progestagens)
5.	Vitamin D
6.	25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)
7.	Enzymes
8.	Calcitriol Receptors (Calcitriol Receptor)
9.	Proteins (Proteins, Gene)
10.	Cholecalciferol (Vitamin D3)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Adjuvant Chemotherapy
4.	Kidney Transplantation
5.	Lasers (Laser)