Mesenteric Ischemia

Ischemic tissue injury produced by insufficient perfusion of intestinal tissue by the MESENTERIC CIRCULATION (i.e., CELIAC ARTERY; SUPERIOR MESENTERIC ARTERY; INFERERIOR MESENTERIC ARTERY; and MESENTERIC VEINS). It can progress from ISCHEMIA; EDEMA; and GANGRENE of the bowel wall to PERITONITIS and cardiovascular collapse.

Also Known As:

Acute Mesenteric Arterial Embolus; Acute Mesenteric Arterial Thrombosis; Mesenteric Vascular Insufficiency; Mesenteric Venous Thrombosis; Nonocclusive Mesenteric Ischemia; Occlusive Mesenteric Arterial Ischemia; Insufficiencies, Mesenteric Vascular; Insufficiency, Mesenteric Vascular; Ischemia, Mesenteric; Ischemia, Nonocclusive Mesenteric; Ischemias, Mesenteric; Ischemias, Nonocclusive Mesenteric; Mesenteric Ischemia, Nonocclusive; Mesenteric Ischemias; Mesenteric Ischemias, Nonocclusive; Mesenteric Vascular Insufficiencies; Mesenteric Venous Thromboses; Nonocclusive Mesenteric Ischemias; Thromboses, Mesenteric Venous; Thrombosis, Mesenteric Venous; Vascular Insufficiencies, Mesenteric; Vascular Insufficiency, Mesenteric; Venous Thromboses, Mesenteric; Venous Thrombosis, Mesenteric

Networked: 1213 relevant articles (61 outcomes, 113 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Reperfusion Injury
2.	Pathologic Constriction (Stenosis)
3.	Thrombosis (Thrombus)
4.	Hemorrhage
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease)

Experts

1.	Oderich, Gustavo S: 11 articles (01/2021 - 09/2009)
2.	Yenisey, Cigdem: 9 articles (03/2015 - 03/2007)
3.	Corcos, Olivier: 8 articles (08/2022 - 06/2014)
4.	Moore, Frederick A: 8 articles (06/2022 - 06/2002)
5.	Wu, Xingjiang: 8 articles (05/2020 - 05/2014)
6.	Tsokos, George C: 8 articles (01/2017 - 12/2003)
7.	Kozar, Rosemary A: 8 articles (09/2011 - 06/2002)
8.	Acosta, Stefan: 7 articles (01/2021 - 01/2005)
9.	Teke, Zafer: 7 articles (02/2013 - 03/2007)
10.	Nuzzo, Alexandre: 6 articles (08/2022 - 06/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mesenteric Ischemia:

1.	Vasodilator Agents (Vasodilators)IBA 10/01/2021 - "Correction to: Local Intra-arterial Vasodilator Infusion in Non-Occlusive Mesenteric Ischemia Significantly Increases Survival Rate." 01/01/2021 - "Local Intra-Arterial Vasodilator Infusion in Non-Occlusive Mesenteric Ischemia: Dealing with One Consequence Hoping to Affect the Cause?" 08/01/2020 - "Local Intra-arterial Vasodilator Infusion in Non-Occlusive Mesenteric Ischemia Significantly Increases Survival Rate." 03/01/2018 - "Vasodilators also play an important role in the early management of mesenteric ischemia. " 01/01/2020 - "Previous studies have suggested that vasodilator therapy may be beneficial for patients with nonocclusive mesenteric ischemia. "
2.	fibrin fragment D (D-dimer)IBA 07/01/2005 - "The longer the duration of mesenteric ischemia, the higher were the serum D-dimer levels in the study groups, and statistical significance was obtained at 2 h (p = 0.021). " 12/01/2014 - "D-dimer as an early marker of severity in patients with acute superior mesenteric venous thrombosis." 09/01/2014 - "Multi-detector angio-CT and the use of D-dimer for the diagnosis of acute mesenteric ischemia in geriatric patients." 10/01/2009 - "D-dimer in patients with suspected acute mesenteric ischemia." 04/01/2009 - "The correlation of the D-dimer test and biphasic computed tomography with mesenteric computed tomography angiography in the diagnosis of acute mesenteric ischemia."
3.	Biomarkers (Surrogate Marker)IBA 06/01/1994 - "No serum marker has consistently proved helpful in diagnosing early acute mesenteric ischemia. " 11/14/2023 - "It is anticipated that the use of electrophysiological slow-wave and spike-burst biomarkers, along with contractile measures, could identify mesenteric ischemia in surgical settings and allow an objective biomarker for successful revascularization." 01/01/2022 - "We aimed to identify plasma biomarkers indicating mesenteric ischemia in patients with CMI and MALS. " 01/01/2022 - "HIF-1α was found to be moderate (AUC: 0.705) and adropin was found to be a weak biomarker (AUC: 0.692) in the ROC analysis for acute mesenteric ischemia. " 01/01/2022 - "The absence of a specific biomarker for acute mesenteric ischemia diagnosis results in a delay in diagnosis and treatment, as well as a high mortality rate. "
4.	Glucagon (Glukagon)FDA Link 05/01/1985 - "The purpose of this study was to determine the optimal timing of intravenous glucagon infusion for the treatment of acute occlusive mesenteric ischemia. " 06/01/1995 - "Effect of intravenous glucagon on intestinal viability after segmental mesenteric ischemia." 10/01/1990 - "Hemodynamic effects of glucagon after acute mesenteric ischemia in rats." 02/01/1990 - "Vasoactive agents, including glucagon, have been used in treatment of mesenteric ischemia. " 07/01/1987 - "Glucagon use in mesenteric ischemia."
5.	SolutionsIBA 09/01/2009 - "Inferior mesenteric artery stenting: a solution for chronic mesenteric ischemia." 11/01/2003 - "We previously showed that infusing rats with a solution of ethyl pyruvate ameliorates intestinal mucosal injury after mesenteric ischemia and reperfusion. " 08/01/2001 - "Treatment with Ringer's ethyl pyruvate solution ameliorated structural and functional damage to the intestinal mucosa in a rat model of mesenteric ischemia/reperfusion. " 05/01/2003 - "Ringer's ethyl pyruvate solution (REPS) has been evaluated in a number of preclinical studies using animal models of mesenteric ischemia/reperfusion injury, hemorrhagic shock, and acute endotoxemia. " 08/01/2001 - "In an effort to take advantage of the ability of pyruvate to scavenge reactive oxygen species while avoiding the problems associated with the instability of pyruvate in solution, we sought to determine whether a simple derivative, ethyl pyruvate, would be protective in an animal model of reactive oxygen species-mediated tissue injury, namely mesenteric ischemia and reperfusion in rats. "
6.	PapaverineIBA 07/01/1992 - "In 3 cases acute mesenteric ischemia was not occlusive and could be successfully treated with papaverine infusion. " 08/01/2020 - "To investigate the outcome of local intra-arterial papaverine infusion therapy in patients with non-occlusive mesenteric ischemia (NOMI), and factors influencing survival, in comparison with a conservative approach. " 02/01/1999 - "Mesenteric ischemia after coronary artery bypass grafting: should local continuous intra-arterial perfusion with papaverine be regarded as a treatment?" 01/01/1998 - "Improved survival from nonocclusive mesenteric ischemia is dependent upon the identification of high-risk groups and on aggressive diagnostic and therapeutic measures (intra-arterial infusion of papaverine through the angiographic catheter with or without bowel resection). " 11/01/2002 - "Similarly, the interventional radiologist can treat acute intestinal ischemia safely and effectively with selective catheterization and papaverine administration and treat chronic mesenteric ischemia by percutaneous angioplasty and stent placement. "
7.	ethyl pyruvateIBA 04/01/2008 - "Ethyl pyruvate was shown to ameliorate some of the structural and functional changes associated with mesenteric ischemia and reperfusion in rats. " 11/01/2003 - "The two highest doses of ethyl pyruvate also significantly ameliorated deficits in ileal serosal and mucosal and hepatic surface microvascular perfusion induced by mesenteric ischemia/reperfusion. " 11/01/2003 - "Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion." 11/01/2003 - "Doses of ethyl pyruvate equal to or greater than 50 mg/kg ameliorate inflammation, microvascular hypoperfusion and gut mucosal damage induced by mesenteric ischemia/reperfusion in mice." 11/01/2003 - "We previously showed that infusing rats with a solution of ethyl pyruvate ameliorates intestinal mucosal injury after mesenteric ischemia and reperfusion. "
8.	Lactic Acid (Lactate)FDA LinkGeneric 06/01/2021 - "Late intraoperative lactate concentrations were significantly greater in patients who subsequently developed mesenteric ischemia (p < 0.001). " 09/01/2023 - "Although CRP is a non-specific parameter in the early diagnosis of acute mesenteric ischemia, lactate maintains its importance as seen in our study. " 04/01/2018 - "The aim of this study was to prospectively evaluate the diagnostic performance of arterial blood gas lactate concentrations in the patients with acute mesenteric ischemia and its different forms. " 03/30/2023 - "In a subgroup analysis of women, preoperative levels of arterial lactate (OR 1.468, 95% CI: 1.133-1.901) and mesenteric ischemia after surgery (OR 32.742, 95% CI: 3.361-319.017) were significantly associated with increased operative mortality. " 12/01/2022 - "Serum lactate admission levels can be considered as a useful prognostic tool in terms of mortality in patients with acute mesenteric ischemia."
9.	PotassiumIBA 10/01/2007 - "In this experimental study we evaluated the pH and potassium changes of the peritoneal irrigation fluid in the early phase of mesenteric ischemia. " 09/01/2014 - "Peritoneal Potassium and pH Measurement in Early Diagnosis of Acute Mesenteric Ischemia in Rats." 10/01/2007 - "In early phase the measurement of potassium and pH in peritoneal irrigation fluid may be an early diagnostic tool for mesenteric ischemia." 10/01/2007 - "[pH value and potassium level of diagnostic peritoneal lavage fluid in the early diagnosis of acute mesenteric ischemia secondary to arterial occlusion in rats]." 01/01/2021 - "The aim of this randomized controlled experimental study was to evaluate the efficacy of potassium, pH and D-dimer levels in blood, as well as potassium and pH levels in peritoneal lavage fluid, in the early diagnosis of acute mesenteric ischemia. "
10.	AnticoagulantsIBA 10/01/2016 - "This method was effective for low mesenteric ischemia, easy to perform, and did not require high doses of anticoagulants." 03/08/2023 - "Immediate postoperative parenteral anticoagulant therapy improves prognosis in patients with acute mesenteric ischemia treated by intestinal resection. " 03/08/2023 - "Immediate postoperative parenteral anticoagulant therapy in patients with mesenteric ischemia after intestinal resection: a retrospective cohort study at a single institute." 09/01/2000 - "Recent portal or mesenteric venous thrombosis: increased recognition and frequent recanalization on anticoagulant therapy." 12/01/1993 - "Mesenteric venous thrombosis is an emergency usually treated by bowel resection with an end-to-end anastomosis and in some cases anticoagulant therapy. "

Therapies and Procedures

1.	Therapeutics 01/01/2001 - "We believe this is the first reported case in the English literature of a patient who developed mesenteric venous thrombosis during L-asp therapy, and once more we advise caution in using conventional blood products, especially cryoprecipitate, and recommend restricting the use of cryoprecipitate and fresh frozen plasma (FFP) to the treatment of serious hemorrhagic manifestations, until new effective and safe therapies are available." 10/01/2020 - "Endovascular therapy for chronic mesenteric ischemia (CMI) is the mainstay of treatment. " 11/15/2011 - "Endovascular treatment of mesenteric ischemia is a safe and effective therapy with acceptable long-term results. " 11/01/2018 - "Improved Prognosis and Low Failure Rate with Anticoagulation as First-Line Therapy in Mesenteric Venous Thrombosis." 06/01/2009 - "Acute mesenteric venous thrombosis: improved outcome with early diagnosis and prompt anticoagulation therapy."
2.	Laparotomy 02/11/2019 - "With regard to the incidence of mesenteric ischemia and survival after laparotomy, off-pump CABG patients revealed significant improvement compared with those operated on with the on-pump technique." 09/01/2017 - "Laparotomy remains the gold standard for diagnosis of acute mesenteric ischemia (AMI), but is often unhelpful or too late due to non-specific clinical and radiological signs. " 08/01/1999 - "Thus, the application of a gastric tonometer in cases of mesenteric venous thrombosis may help to reduce costs by preventing unnecessary postoperative diagnostic maneuvers such as angiography, computed tomography, or even second-look laparotomy." 04/01/2022 - "The present study reported perioperative changes in PCT levels occurring in cardiac patients with acute mesenteric ischemia (AMI) undergoing laparotomy. " 01/01/2022 - "The study population was divided into two groups as patients who underwent surgery for causes non-related to mesenteric ischemia (Group 1) and patients with findings of mesenteric ischemia who underwent laparotomy (Group 2). "
3.	Endovascular Procedures 11/01/2007 - "Pending more data on the acute and long-term results of endovascular techniques, open mesenteric revascularization remains the gold standard for most patients with chronic mesenteric ischemia." 05/01/2022 - "Although retrograde open mesenteric artery stenting (ROMS) has been primarily shown to be effective in acute mesenteric ischemia, this case demonstrates that ROMS can be used as a salvage option for shuttering during endovascular procedures." 02/01/2017 - "The rise of endovascular techniques has improved the outcome of mesenteric ischemia. " 02/01/2016 - "Mortality of acute mesenteric ischemia remains unchanged despite significant increase in utilization of endovascular techniques." 11/01/2015 - "Acute mesenteric ischemia: Utility of endovascular techniques."
4.	Stents 04/01/2012 - "The purpose of this study was to describe the incidence, management, and outcomes of mesenteric artery complications (MACs) during angioplasty and stent placement (MAS) for chronic mesenteric ischemia (CMI). " 02/22/2011 - "[Acute superior mesenteric ischemia: a contrast study on short-and mid-term result between stent implantation and pharmaceutical thrombolysis]." 03/01/2008 - "This study evaluated patency and mortality, and their relationship between degree of vessel occlusion (stenotic or totally occluded), stent characteristics, and comorbidities in patients who were treated with PTAS of the visceral vessels for chronic mesenteric ischemia. " 09/01/2023 - "In the present case report, we describe a rare case of mesenteric ischemia due to superior mesenteric artery ostium coverage by the misalignment of a renal stent graft in a Ch-EVAR." 06/21/2021 - "Acute mesenteric ischemia Angioplasty, Bypass, stent,Thrombolysis. "
5.	Catheters 10/01/2020 - "The purpose of this study was to describe the use of the OUTBACK catheter to overcome aortic reentry issues in acute mesenteric ischemia (AMI) treated by retrograde open mesenteric stenting (ROMS). " 08/12/2022 - "Primary Catheter-Directed Thrombolysis for Porto-Mesenteric Venous Thrombosis (PMVT) in Non-Cirrhotic Patients." 01/01/2018 - "Patients with clinical suspicion of nonocclusive mesenteric ischemia underwent catheter angiography of the superior mesenteric artery. " 08/01/2016 - "Postoperative Catheter-Directed Thrombolysis Versus Systemic Anticoagulation for Acute Superior Mesenteric Venous Thrombosis." 01/01/2015 - "The gastric pH (pHi) and gastric CO2 (gpCO2) were measured with gastric tonometry catheter, preoperatively and postoperatively at 24 hours, in patients with suspicion of acute mesenteric ischemia. "