Abstract | Background: Methods: Plasma α- glutathione S-transferase (α-GST), intestinal fatty acid-binding protein (I-FABP), citrulline, and ischemia modified albumin (IMA) were analyzed in fifty-eight patients with CMI (Group A, n=44) and MALS (Group B, n=14) before and after revascularization. The plasma levels of these potential biomarkers were compared with those of healthy individuals (Group C, n=16). Group comparison was performed with the Mann-Whitney U-test. Cross-tabulation and its derivatives were obtained. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were calculated. Results: Plasma levels of α-GST were significantly raised in the patients with CMI (7.8 ng/mL, p<0.001) and MALS (8.4 ng/mL, p<0.001), as compared with the control Group C (3.3 ng/mL). The threshold for normal median plasma α-GST levels of 4 ng/mL yielded a sensitivity of 93% and 86%, specificity of 86% and 88%, respectively, for the diagnosis of CMI due to atherosclerosis and MALS. AUC of ROC curves was 0.96 (p<0.0001) for CMI and 0.85 (p<0.002) for MALS. The patient groups did not differ from the healthy controls in any other biomarkers. Conclusion: Plasma α-GST levels are elevated in CMI and MALS patients. Elevated plasma levels of α-GST suggest ischemia as the etiology of MALS.
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Authors | Syed Sajid Hussain Kazmi, Nathkai Safi, Simen Tveten Berge, Marryam Kazmi, Jon Otto Sundhagen, Kari Julien, Per Medbøe Thorsby, Kim Vidar Ånonsen, Asle Wilhelm Medhus, Jonny Hisdal |
Journal | Vascular health and risk management
(Vasc Health Risk Manag)
Vol. 18
Pg. 567-574
( 2022)
ISSN: 1178-2048 [Electronic] New Zealand |
PMID | 35903288
(Publication Type: Journal Article)
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Copyright | © 2022 Kazmi et al. |
Chemical References |
- Biomarkers
- Serum Albumin
- Glutathione Transferase
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Topics |
- Atherosclerosis
- Biomarkers
- Celiac Artery
- Chronic Disease
- Glutathione Transferase
- Humans
- Ischemia
- Median Arcuate Ligament Syndrome
(diagnosis)
- Mesenteric Ischemia
(diagnostic imaging)
- Serum Albumin
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