Lipedema

Disorder of adipose tissue characterized by symmetric and bilateral enlargement of the lower extremities due to abnormal deposition of SUBCUTANEOUS FAT often in obese women. It is associated with HEMATOMA, pain and may progress to secondary LYMPHEDEMA which is known as lipolymphedema.

Also Known As:

Networked: 167 relevant articles (25 outcomes, 41 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Lipodystrophy
3.	Lymphedema (Milroy Disease)
4.	Obesity
5.	Overweight

Experts

1.	Herbst, Karen L: 7 articles (07/2022 - 09/2016)
2.	Ghods, Mojtaba: 7 articles (03/2022 - 07/2017)
3.	Wollina, Uwe: 7 articles (01/2021 - 01/2014)
4.	Kruppa, Philipp: 6 articles (03/2022 - 12/2018)
5.	Sandhofer, Matthias: 5 articles (05/2022 - 01/2017)
6.	Georgiou, Iakovos: 5 articles (03/2022 - 06/2020)
7.	Schmidt, Jeremias: 5 articles (03/2022 - 11/2020)
8.	Barsch, Martin: 4 articles (05/2022 - 01/2020)
9.	Crescenzi, Rachelle: 4 articles (01/2022 - 01/2018)
10.	Donahue, Manus J: 4 articles (01/2022 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lipedema:

1.	Cytidine Diphosphate (CDP)IBA 01/01/2017 - "Our study group has recently demonstrated that lipedema-associated bruising is correlated with increased capillary fragility (CF) and also that CF could be significantly improved by complex decongestive physiotherapy (CDP). " 01/01/2022 - "Conclusion: A treatment program consisting of CDP and IPC can be effective in reducing the circumference and volume of the arm in patients with upper extremity lipedema. " 01/01/2021 - "Conclusion: This reduction indicates that CDP is effective in the treatment of lower extremity lipedema. " 01/01/2022 - "Objective: The aim of this study is to investigate the effect of complex decongestive physiotherapy (CDP) plus intermittent pneumatic compression (IPC) applications on upper extremity circumference and volume in patients with lipedema. " 01/01/2021 - "Background: The aim of this study is to investigate the effect of complex decongestive physiotherapy (CDP) plus intermittent pneumatic compression (IPC) applications on lower extremity limb circumference and volume in patients with lipedema. "
2.	CarbohydratesIBA 08/01/2022 - "Current experience indicates that a low carbohydrate and high fat (LCHF-diet) might have a beneficial effect on weight and symptom management in lipedema. " 01/01/2022 - "The Effect of a Low-Carbohydrate, High-Fat Diet versus Moderate-Carbohydrate and Fat Diet on Body Composition in Patients with Lipedema." 06/02/2023 - "The aim of this study was to evaluate alterations in blood parameters after a low-carbohydrate high-fat (LCHF) diet in women with lipedema in comparison to overweight or obese women. " 06/02/2023 - "The Effect of a Low-Carbohydrate High-Fat Diet on Laboratory Parameters in Women with Lipedema in Comparison to Overweight/Obese Women." 01/01/2023 - "The Benefits of Low-Carbohydrate, High-Fat (LCHF) Diet on Body Composition, Leg Volume, and Pain in Women with Lipedema."
3.	CytokinesIBA 03/24/2021 - "As cytokines can influence metabolic activity, the metabolic phenotype of the stromal vascular fraction was examined, revealing significantly increased mitochondrial respiration in lipedema. " 01/01/2020 - "The changes in the lymphatic-related cytokine milieu might be related to a modified vascular permeability developed secondarily to lipedema progression." 03/24/2021 - "As hyperplastic adipose tissue represents low-grade inflammation, the potential systemic effects on circulating cytokines were evaluated in lipedema and control patients using the Multiplex immunoassay system. " 11/30/2022 - "Research to understand the pathology of lipedema is still in its infancy, but promising markers derived from exosome, cytokine, lipidomic, and metabolomic profiling studies suggest a condition distinct from obesity and lymphedema. " 10/23/2023 - "In this study, the expression of MIF-1, MIF-2 and CD74-a common receptor for both cytokines-was analyzed in tissue samples of 11 lipedema and 11 BMI-matched, age-matched and anatomically matched control patients using qPCR and immunohistochemistry (IHC). "
4.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 06/01/2023 - "This study aimed to assess the presence or absence of lymphoedema in the lower limbs of women with lipoedema using indocyanine green (ICG) lymphography. " 01/01/2022 - "The aim of our study was to describe the functional status and anatomy of lower limb superficial lymphatic system using indocyanine green (ICG) lymphography in patients with lipedema. " 06/01/2023 - "Differentiation of lipoedema from bilateral lower limb lymphoedema by imaging assessment of indocyanine green lymphography." 01/01/2022 - "Indocyanine green lymphography as novel tool to assess lymphatics in patients with lipedema."
5.	SodiumIBA 01/01/2020 - "The aim of this study is to compare tissue sodium and fat content in the upper and lower extremities of participants with lipedema versus controls using magnetic resonance imaging (MRI). " 01/01/2020 - "Findings provide evidence that brain sodium and tissue fractions are similar between patients with lipedema and control participants and that patients with lipedema do not exhibit abnormal radiological indicators of intracranial vasculopathy or ischemic injury. " 01/01/2020 - "Neuroimaging of Cerebral Blood Flow and Sodium in Women with Lipedema." 01/01/2020 - "MRI-measured tissue sodium and fat content are significantly higher in the lower extremities, but not upper extremities, of patients with lipedema compared with BMI-matched controls." 01/01/2020 - "Upper and Lower Extremity Measurement of Tissue Sodium and Fat Content in Patients with Lipedema."
6.	MicroRNAs (MicroRNA)IBA 01/01/2020 - "This study contributes to identify the potential role of SVF secreted miRNAs in lipedema." 01/01/2020 - "The aim of this study was a thorough comparative characterization of extracellular microRNAs (miRNAs) from the stromal vascular fraction (SVF) of healthy and lipedema adipose tissue. " 01/01/2020 - "Comparing SVF from healthy and lipedema patients, we identified sEVs as the lipedema relevant miRNA fraction. " 01/01/2020 - "Surprisingly, hierarchical clustering of the most variant miRNAs showed that only sEVmiRNA profiles - but not cCMmiRNAs - were impacted by lipedema. " 01/01/2020 - "SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema."
7.	Interleukin-6 (Interleukin 6)IBA 01/01/2020 - "The study of the relationship between the IL-6 (rs1800795) gene polymorphism, the anthropometric values and the body composition indices has provided the following significant results: subjects with diagnosis of lipedema present statistically significant increased values with regard to weight, BMI, waist, abdomen and hip circumferences, arms, legs and whole FM (% and kg), gynoid FM (kg), legs LM (kg) and ASMMI. " 01/01/2020 - "The aim of this study was to evaluate the lipedema phenotype by investigating the role of polymorphisms related to IL-6 (rs1800795) gene in people with diagnosis of lipedema. " 01/01/2020 - "For the first time, we suggested that IL-6 gene polymorphism could characterize subjects with lipedema respect to Normal Weight Obese and obese subjects. " 01/01/2020 - "The role of IL-6 gene polymorphisms in the risk of lipedema."
8.	SeleniumIBA 04/25/2020 - "Selenium deficiency proved common in patients with lymphedema, lipedema, and lipo-lymphedema affecting 47.5% of the study population. " 04/25/2020 - "Selenium Deficiency in Lymphedema and Lipedema-A Retrospective Cross-Sectional Study from a Specialized Clinic." 04/25/2020 - "Obesity was a risk factor for selenium deficiency in lymphedema (OR 2.19; 95% CI 1.49 to 3.21), but not in lipedema. "
9.	MSH Release-Inhibiting Hormone (MIF-I)IBA 10/23/2023 - "In this study, the expression of MIF-1, MIF-2 and CD74-a common receptor for both cytokines-was analyzed in tissue samples of 11 lipedema and 11 BMI-matched, age-matched and anatomically matched control patients using qPCR and immunohistochemistry (IHC). " 10/23/2023 - "The mRNA expression of MIF-1 (mean 1.256; SD 0.303; p = 0.0485) and CD74 (mean 1.514; SD 0.397; p = 0.0097) were significantly elevated in lipedema patients, while MIF-2 expression was unaffected (mean 1.004; SD 0.358; p = 0.9718). "
10.	HLA-DQ8 antigenIBA 07/01/2023 - "Objective The aim of this study is to assess the prevalence of HLA-DQ2 and HLA-DQ8 in women diagnosed with lipedema. " 07/01/2023 - "Conclusion Lipedema patients seeking medical assistance have a higher prevalence of HLA-DQ2 and HLA-DQ8. " 07/01/2023 - "Compared to the general population, there was a significantly higher prevalence of HLA-DQ2, HLA-DQ8, any HLA, and both HLAs in lipedema patients. " 07/01/2023 - "Assessing the Prevalence of HLA-DQ2 and HLA-DQ8 in Lipedema Patients and the Potential Benefits of a Gluten-Free Diet."

Therapies and Procedures

1.	Lipectomy (Liposuction) 01/01/2012 - "Tumescent liposuction is a highly effective treatment for lipoedema with good morphological and functional long-term results." 12/01/2021 - "Before treatment with liposuction, disease-specific QoL in patients with lipoedema was low on every single subscale as well as on the global score and showed a significant improvement in all aspects after liposuction. " 01/01/2006 - "Tumescent liposuction: a new and successful therapy for lipedema." 01/01/2011 - "Liposuction is an effective treatment for lipedema-results of a study with 25 patients." 01/01/2019 - "Liposuction is an effective treatment for painful lipedema. "
2.	Therapeutics 10/01/2014 - "Compression therapy is the mainstay of treatment in the management of lymphoedema and lipoedema. " 01/01/2023 - "The results demonstrate improved clinical and functional ultrasound findings in patients affected by lipedema in the early stages of lower limbs, and this combination therapy needs to be investigated in larger populations at multiple centers to confirm the findings." 10/01/2020 - "Complex decongestive therapies are helpful in reducing the lymph stagnation, especially in patients with advanced lipolymphedema." 01/04/2023 - "(2) Methods: Six women with lipedema were enrolled in the study; three were undergoing exercise program and compression therapy using compression leggings, and the remaining three were undergoing exercises only. " 01/01/2021 - "This study investigated the effects of exercise-based rehabilitation combined with complete decongestive therapy (CDT) or intermittent pneumatic compression therapy (IPCT) or alone in patients with severe lipedema. "
3.	Conservative Treatment 10/01/2022 - "(4) Conclusion: The tools currently used in evaluating the effectiveness of conservative treatment in women with lipoedema are: volume and circumference measurement, waist-to-hip ratio, body fat percentage, ultrasonography, VAS scale, quality of life scales (SF-36, RAND-36), symptom severity questionnaire (QuASiL), Lower Extremity Functional Scale and 6 min walk. " 10/01/2022 - "A Scoping Review of Available Tools in Measurement of the Effectiveness of Conservative Treatment in Lipoedema." 01/01/2022 - "Further research is warranted to optimize the conservative therapy approach in lipedema, a condition for which curative and disease-modifying treatments are unavailable." 04/01/2017 - "The guidelines define criteria to make a medical diagnosis of lipedema, a minimum data set of (repeated) clinical measurements that should be used to ensure early detection and an individually outlined follow-up plan, pillars on which conservative treatment should be based and recommendations on surgical treatment options. " 09/01/2020 - "Liposuction in water-jet-assisted technique using the presented treatment protocol is an efficient method of operative treatment of early-stage lipedema patients leading to a marked decrease in symptom severity and need for conservative treatment."
4.	Anesthesia 05/01/2015 - "Microcannular liposuction in tumescent anesthesia is the most effective treatment for painful lipedema. " 01/01/2021 - "The aim of the study was to broaden the evidence on the safety of ambulatory high-volume liposuction in tumescent anesthesia in lipedema patients. " 09/01/2023 - "[Microcannular liposuction in tumescent anesthesia in lipedema patients: an analysis of 519 liposuctions]." 01/01/2021 - "Liposuction under high volume tumescent anesthesia for the treatment of lipedema patients is, even for major intervention, a safe procedure. " 01/01/2021 - "High Volume Liposuction in Tumescence Anesthesia in Lipedema Patients: A Retrospective Analysis."
5.	Mediterranean Diet 11/04/2023 - "Recent studies have suggested that VLCKD may be an effective treatment for lipedema, demonstrating that it is also superior to other nutritional approaches such as Mediterranean diet or intermittent fasting. " 01/25/2021 - "Potential Effects of a Modified Mediterranean Diet on Body Composition in Lipoedema." 01/25/2021 - "The study was conducted to evaluate body composition and general health status modification in a group of lipoedema patients (LIPPY) and a control group (CTRL) after four weeks of a modified Mediterranean diet therapy (mMeD). "