beta-Lactamase Inhibitors

Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES.

Also Known As:

beta Lactamase Antagonists; Antagonists, beta Lactamase; Inhibitor, beta Lactamase; Inhibitor, beta-Lactamase; Inhibitors, beta Lactamase; Inhibitors, beta-Lactamase; Lactamase Antagonists, beta; Lactamase Inhibitor, beta; Lactamase Inhibitors, beta; beta Lactamase Inhibitor; beta Lactamase Inhibitors; beta-Lactamase Inhibitor

Networked: 313 relevant articles (32 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Anti-Infective Agents: 8032
      - Anti-Bacterial Agents: 148582
        beta-Lactamase Inhibitors: 313
  - Molecular Mechanisms of Pharmacological Action: 24
    - Enzyme Inhibitors: 1659
      - beta-Lactamase Inhibitors: 313

Experts

1.	Bonomo, Robert A: 5 articles (01/2019 - 05/2004)
2.	Viaggi, Bruno: 3 articles (12/2021 - 06/2021)
3.	Paterson, David L: 3 articles (01/2020 - 02/2008)
4.	Gatti, Milo: 2 articles (12/2021 - 05/2021)
5.	Pea, Federico: 2 articles (12/2021 - 05/2021)
6.	Rossolini, Gian Maria: 2 articles (12/2021 - 05/2006)
7.	Meini, Simone: 2 articles (06/2021 - 06/2021)
8.	Tascini, Carlo: 2 articles (06/2021 - 06/2021)
9.	Bhowmick, Tanaya: 2 articles (12/2020 - 01/2018)
10.	Harris, Patrick N A: 2 articles (01/2020 - 01/2015)

Related Diseases

1.	Infections 05/01/2015 - "Novel beta-lactamase inhibitors may also have a role in future treatment of these infections. " 05/01/2002 - "The potential importance of these findings is that this beta-lactamase inhibitor combination can be used an empiric treatment of serious infections in hospital environments where resistance has emerged, as well as covering nearly all isolates of fastidious respiratory tract pathogens acquired in the community setting." 01/01/1994 - "The association an aminopenicillin with a beta-lactamase inhibitor is recommended for prophylaxis of surgical infections. " 09/28/1991 - "Aminopenicillin/beta-lactamase inhibitor combinations may be a suitable therapeutic option in treating mild to moderately severe infections, i.e. " 01/01/2016 - "baumannii infections, studies concerning novel beta-lactamase inhibitors offer a new insight into effective therapy."
2.	Pneumonia (Pneumonitis) 01/01/1998 - "Switch therapy with beta-lactam/beta-lactamase inhibitors in patients with community-acquired pneumonia." 06/01/1992 - "Efficacy of sulbactam, a beta-lactamase inhibitor, in combination with ampicillin, was evaluated for treatment of experimentally induced pneumonia caused by beta-lactam-resistant Klebsiella pneumoniae. " 06/01/2003 - "Clinical effect of ampicillin with beta-lactamase inhibitor (sulbactam/ampicillin) on community-acquired pneumonia in the elderly." 06/01/1999 - "In vivo efficacies of combinations of beta-lactams, beta-lactamase inhibitors, and rifampin against Acinetobacter baumannii in a mouse pneumonia model." 01/01/1998 - "The prospective use of a program that incorporates the use of beta-lactam/beta-lactamase inhibitor combinations for intravenous and switch-to-oral drug administration is a cost-effective means of providing optimal antimicrobial therapy for patients with community-acquired pneumonia."
3.	Endocarditis 09/01/1981 - "Efficacy of ampicillin plus a beta-lactamase inhibitor (CP-45,899) in experimental endocarditis due to Staphylococcus aureus." 09/01/1981 - "The efficacy of combined therapy with ampicillin and a beta-lactamase inhibitor, CP-45,899, for experimental endocarditis due to Staphylococcus aureus was evaluated. " 11/01/1987 - "Bactericidal interactions of a beta-lactam and beta-lactamase inhibitors in experimental Pseudomonas aeruginosa endocarditis caused by a constitutive overproducer of type Id beta-lactamase." 04/01/1995 - "Ampicillin or amoxicillin at 625-800 mg/kg/day, in combination with a beta-lactamase inhibitor, each is as effective as vancomycin in animal models of methicillin-resistant Staphylococcus aureus endocarditis. " 09/01/1992 - "The efficacy of tazobactam, a beta-lactamase inhibitor, in combination with piperacillin, was studied in vitro and in rabbit experimental endocarditis due to a Klebsiella pneumoniae strain (KpR) producing an extended-spectrum beta-lactamase, TEM-3, or its nonproducing variant (KpS). "
4.	Intraabdominal Infections 02/01/1993 - "Efficacy of a beta-lactamase inhibitor combination for serious intraabdominal infections." 01/01/2000 - "Extended-spectrum penicillin/beta-lactamase-inhibitor combinations are effective in the treatment of intra-abdominal infections and include enterococci in their spectrum. " 05/01/1995 - "Clinical trials of extended spectrum penicillin/beta-lactamase inhibitors in the treatment of intra-abdominal infections. " 05/01/1995 - "The clinical results with the beta-lactam/beta-lactamase inhibitor class of antimicrobials in the treatment of intra-abdominal infections are reviewed. " 06/01/2009 - "Amoxicillin-sulbactam (AMX-SUL) is an aminopenicillin/beta-lactamase inhibitor combination currently available in 29 countries which may be a suitable option for treating intra-abdominal infections. "
5.	Bacterial Infections (Bacterial Infection) 08/01/1999 - "The development of beta-lactamase inhibitors allows clinicians to rely on the well-tolerated, clinically effective beta-lactam antibiotics to treat a variety of bacterial infections." 05/01/2021 - "Several novel beta-lactams (BLs) and/or beta lactams/beta-lactamase inhibitors (BL/BLIs) have been recently developed for the management of multidrug-resistant bacterial infections. " 10/01/2001 - "Combinations of beta-lactams and beta-lactamase inhibitors have become one of the most successful antibacterial strategies in our global battle against bacterial infections. " 02/01/2000 - "beta-Lactamase inhibitor:beta-lactam combinations remain one of the most successful strategies for the treatment of bacterial infections. " 06/01/1998 - "Beta-lactam/beta-lactamase inhibitor combinations: pharmacodynamic considerations and possible role in the management of bacterial infections in the neutropenic host."

Related Drugs and Biologics

1.	beta-Lactams
2.	Ampicillin (Omnipen)
3.	Sulbactam
4.	Carbapenems (Carbapenem Antibiotics)
5.	Clavulanic Acid (Potassium Clavulanate)
6.	Piperacillin
7.	beta-Lactamases (beta-Lactamase)
8.	Cephalosporins (Cephalosporin Antibiotics)
9.	Amoxicillin (Wymox)
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Intramuscular Injections
4.	Renal Dialysis (Hemodialysis)
5.	Cesarean Section (Caesarean Section)