Dysbiosis

Changes in quantitative and qualitative composition of MICROBIOTA. The changes may lead to altered host microbial interaction or homeostatic imbalance that can contribute to a disease state often with inflammation.

Also Known As:

Networked: 6825 relevant articles (432 outcomes, 761 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inflammation (Inflammations)
2.	Colitis
3.	Obesity
4.	Neoplasms (Cancer)
5.	Diarrhea

Experts

1.	Chen, Wei: 22 articles (08/2022 - 01/2018)
2.	Suchodolski, Jan S: 22 articles (01/2022 - 01/2012)
3.	Zhang, Hao: 19 articles (08/2022 - 01/2018)
4.	Zhang, Li: 17 articles (01/2022 - 01/2016)
5.	Jin, Yuanxiang: 16 articles (01/2022 - 09/2015)
6.	Li, Lanjuan: 15 articles (01/2022 - 08/2013)
7.	Li, Ming: 15 articles (01/2022 - 12/2012)
8.	Fu, Zhengwei: 15 articles (12/2021 - 09/2015)
9.	Steiner, Jörg M: 15 articles (11/2020 - 01/2012)
10.	Yang, Jing: 14 articles (12/2022 - 10/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dysbiosis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2018 - "Notably, dysbiosis correction through the inoculation of a complex microbiota in antibiotics-treated animals reversed these phenotypes and improved the ability of MAIT cells to proliferate. " 01/01/2017 - "Probiotics are believed to be beneficial in maintaining a healthy gut microbiota whereas antibiotics are known to induce dysbiosis. " 01/01/2023 - "Local therapeutic intervention with a broad spectrum of antibiotics was effective in reversing microbiota dysbiosis and suppressing carcinogenic progression. " 11/01/2019 - "Antibiotics represent the mainstay of treatment, suggesting a crucial role of dysbiosis in the pathogenesis of this condition. " 07/29/2021 - "Protective Effects of Probiotics on Cognitive and Motor Functions, Anxiety Level, Visceral Sensitivity, Oxidative Stress and Microbiota in Mice with Antibiotic-Induced Dysbiosis."
2.	Volatile Fatty AcidsIBA 01/01/2019 - "This study demonstrated LC supplementation improved high-fat diet (HFD)-induced gut microbiota dysbiosis and significantly enhanced short-chain fatty acid (SCFA)-producing bacteria (e.g., Blautia) along with SCFA content accumulation in the gut. " 08/01/2022 - "plantarum strains improved dysbiosis and enhanced the abundance of beneficial bacteria related to short-chain fatty acids (SCFAs) production. " 06/01/2022 - "Furthermore, LWE significantly improved microbiota dysbiosis via an increase in gut microbiota diversity and an abundance of the microbiota that produce short chain fatty acids (SCFAs), such as Ruminococcaceae, Faecalibaculum, Intestinimonas, and Alistipes. " 01/24/2022 - "Besides, A-FBTP supplementation effectively improved CTX-induced gut microbiota dysbiosis, including promoting the abundance of beneficial bacteria (e.g., Lactobacillus) and short chain fatty acid (SCFA)-producing bacteria (e.g., Lachnospiraceae, Prevotellaceae and Ruminococcaceae), along with reducing the growth of potentially pathogenic microbes (e.g., Desulfovibrionaceae and Helicobacter). " 01/01/2022 - "laterosporus BL1 intervention significantly improved HFD-induced gut flora dysbiosis, as evidenced by a reverse in the relative abundance of Bacillota and Bacteroidota, as well as an increase in the relative abundance of bacteria that produce short-chain fatty acids (SCFAs), which in turn increased SCFAs levels. "
3.	PrebioticsIBA 01/01/2022 - "In conclusion, the Chinese herbs complex is effective in restoring the gut microbiota caused by cold exposure, improving the function of the intestinal barrier, and may act as a prebiotic in combatting gut dysbiosis." 07/28/2023 - "While all prebiotics slightly improved gut dysbiosis, RMD remarkably promoted the relative abundance and the combined abundance of Lactobacillus, Bifidobacteria, Akkermansia, and Roseburia in CKD rats. " 01/01/2021 - "These results suggest that XOS can relieve dysbiosis in the feces of UC patients in clinical remission and thus represent a potential prebiotic material for maintaining remission." 06/01/2017 - "This review will outline the interconnection between CKD progression, dysbiosis and URS production and will discuss mechanisms of action and efficacy of prebiotics as a new CKD management tool, with a particular emphasis on URS generation." 04/27/2023 - "Conversely, probiotics, prebiotics, and synbiotics have shown promise in restoring dysbiosis and lowering clinical indicators of disease in a number of both preclinical and clinical studies. "
4.	CytokinesIBA 01/01/2013 - "The interest in probiotic preventative/therapeutic potential in allergic diseases stemmed from the fact that probiotics have been shown to improve intestinal dysbiosis and permeability and to reduce inflammatory cytokines in human and murine experimental models. " 03/20/2023 - "Moreover, in vitro and animal studies have shown that QS molecules can modulate cytokine responses and gut dysbiosis and maintain intestinal barrier function. " 01/01/2022 - "Our study revealed that prenatally induced dysbiosis in mice led to an increase in pulmonary Th17+ non-conventional T cells with limited functional effect on airway resistance, pro-asthmatic Th2/Th17 cytokine production, pulmonary localization and cell-cell contacts. " 01/01/2021 - "In conclusion, our results suggested that dysbiosis of endometrial microbiota and the inflammatory cytokines were associated with Micrococcus in EC patients, which might be useful for exploration of the mechanism between the endometrial microbiota and inflammatory responses in future studies." 02/01/2020 - "Study on the correlation among dysbacteriosis, imbalance of cytokine and the formation of intrauterine adhesion."
5.	16S Ribosomal RNAIBA 01/24/2022 - "Using 16S rRNA high-throughput sequencing of feces, WHH2078 was shown to improve the CUMS-induced gut microbial dysbiosis, through restoring alpha diversity and the abundances of Firmicutes and Bacteroidetes. " 11/15/2017 - "Fecal 16s rRNA high-throughput sequencing demonstrated a significant improvement in UC intestinal dysbacteriosis in mice treated with HLJ2, including increased abundance of probiotics such as Lachnospiraceae, Prevotellaceae, and Lactobacillaceae. " 08/05/2020 - "16S rRNA gene sequencing demonstrated that CCL7 overexpression in intestinal epithelial cells improved HFD-induced gut microbial dysbiosis. " 01/01/2019 - "Using 16S rRNA-amplicon sequencing of faces, E41 and M2CF22M7 were found to improve the chronic-stress-induced microbial dysbiosis. " 01/01/2023 - "In this study, we performed the first exploratory analysis of gut microbiota in WBS patients compared to healthy subjects (CTRLs) using 16S rRNA amplicon sequencing, by investigating the gut dysbiosis in relation to diseases and comorbidities. "
6.	Butyrates (Butyrate)IBA 07/20/2021 - "The AG shows potential against gut dysbiosis, as it promotes gut-probiotics, through modulation of microbial population and SCFA production, especially butyrate." 09/26/2021 - "Interestingly, ECP improved intestinal dysbiosis caused by HFD and reshaped the structure of the gut microbiota in diseased mice by increasing the abundance of butyrate-producing bacterium, Eubacterium xylanophilum, in the gut. " 11/01/2019 - "Moreover, the stress-induced structural and functional dysbiosis of the gut microbiome was improved by CCFM687, through increased alpha diversity and abundance of butyrate-producing bacteria, in conjunction with inhibition of pathogenic gene expression. " 04/22/2014 - "This study will help in understanding the role of butyrate producers in health and disease and may assist the development of treatments for functional dysbiosis." 09/09/2023 - "In conclusion, the favorable progression of HF patients after the initial episode was linked to the reversal of gut microbiota dysbiosis and increased SCFA production, particularly butyrate. "
7.	Biomarkers (Surrogate Marker)IBA 01/01/2019 - "Patients with CD in clinical, biomarker, and mucosal remission showed significantly reduced microbial richness and increased dysbiosis index compared with healthy controls. " 01/01/2023 - "Furthermore, the improvement in gut dysbiosis and intestinal leakage after probiotics consumption may reduce inflammatory biomarkers and avoid unnecessary activation of the immune system. " 02/03/2023 - "Although the function of circulating cfmDNA needs to be elucidated (whether it acts as a bystander of dysbiosis or a key player in disease development), several studies have demonstrated its potential as a non-invasive biomarker that may improve diagnosis and treatment efficacy. " 01/01/2023 - "Previous studies found that dysbiosis has been implicated in a wide range of diseases, while the role of gastric bacteria as a biomarker for AG has not been explored. " 03/30/2022 - "This study provides a global snapshot of the existence of oral dysbiosis associated with UC, and the possible presence of potential oral biomarkers."
8.	Polysaccharides (Glycans)IBA 04/30/2022 - "Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-κB signaling pathway." 08/12/2021 - "militaris-polysaccharide treatment obviously improved intestinal dysbiosis through promoting the population of next generation probiotic Akkermansia muciniphila in the gut of mice fed HFSD. " 10/30/2022 - "With the continuous development and utilization of marine resources, marine polysaccharides have been found to regulate dysbiosis in many studies. " 06/01/2017 - "Therefore, this study investigates the effects of apple polysaccharides (AP) on gut dysbiosis. " 07/01/2023 - "Nonetheless, seaweed polysaccharides administration could recover the gut microbial dysbiosis and the loss of gut microbial diversity induced by LPS exposure. "
9.	LipidsIBA 07/01/2023 - "The objective of this study was to investigate the mechanism by which Lactobacillus plantarum HF02 (LP-HF02) alleviated lipid accumulation and intestinal microbiota dysbiosis in high-fat diet-induced obese mice. " 03/15/2021 - "In order to explore the relevance of a direct dysbiosis effect of gut microbiome on lipids metabolism shifts and repaired position of DHA, we built the animal model for the study with gut microbiome dysbiosis administrated by i.g. " 11/07/2023 - "Modulation of the immune system may be driven by: low-level HIV replication, co-pathogens, gut dysbiosis /translocation, altered lipid profiles, and ART toxicities. " 08/16/2023 - "TPE also regulates the expression of liver lipid metabolic genes (i.e., Hmgcr, Srebp-1, Fasn, and Cyp7a1), enhancing the production of SCFAs and regulating serum metabolites by modulating gut microbial dysbiosis. " 07/01/2023 - "Lactobacillus plantarum HF02 alleviates lipid accumulation and intestinal microbiota dysbiosis in high-fat diet-induced obese mice."
10.	Proteins (Proteins, Gene)FDA Link 04/01/2023 - "The synthesized HUR exhibits notable therapeutic efficacy, including mucosa recovery, epithelium integrity restoration, and TJ proteins upregulation via H2 S scavenging to protect against intestinal barrier damage and microbiome dysbiosis. " 07/20/2021 - "Understanding and focusing on these key proteins will pave the way for future mechanistic level cause-effect studies of gut dysbiosis and diseases." 03/01/2021 - "It is intended to study the correlation between gut proteins glycation and microbial dysbiosis and thereby progression to diabetes. " 01/01/2021 - "This study aims to investigate the hepatoprotective effects of Coprinus comatus protein (CCP) in a mouse model of acute alcoholic liver injury by regulating gut microbiota dysbiosis. " 07/06/2023 - "Antimicrobial and defense proteins are important factors that could help characterize the role of microorganisms in CRSwNP pathogenesis, as the concept of microbial dysbiosis in CRS is still being considered. "

Therapies and Procedures

1.	Therapeutics 04/19/2023 - "Finally, we examined a subset of 53 patients following 12 months of therapy and could show resolution of oral dysbiosis as demonstrated by a shift towards a healthy community structure and a significant reduction in oral dysbiosis. " 01/01/2021 - "Probiotics that improves oral dysbiosis may be beneficial for patients with PPP as an adjunctive therapy." 01/01/1984 - "On the basis of the selected mutant, a sour milk product (propioni-acidophilic milk) was prepared and used with good results in complex therapy of intestinal dysbacteriosis in 1148 children aged 4 to 18 months. " 10/01/2020 - "iners while sparing protective vaginal lactobacilli may provide novel pharmacological tools to better understand the roles of this enigmatic bacterium in vaginal ecology and potentially lead to new and improved therapies for dysbiosis-related conditions such as BV." 01/01/2020 - "These findings should stimulate thinking, investigations and better therapy against MAP and the dysbiosis of the gut flora, to enable higher rates of prolonged remission."
2.	Fecal Microbiota Transplantation 10/01/2017 - "Although such association does not imply causation, it has been shown that fecal microbiota transplantation (FMT) can correct the dysbiosis that characterizes chronic and recurring CDI and that FMT can effect a seemingly safe and rapidly effective cure for most patients with CDI so treated. " 02/01/2013 - "It has become recognized that fecal microbiota transplantation (FMT) can correct the dysbiosis that characterizes chronic CDI, and effect a seemingly safe, relatively inexpensive, and rapidly effective cure in the vast majority of patients so treated. " 01/01/2020 - "Our team has developed an orally administered fecal microbiota transplantation product that is effective in reversing dysbiosis in recurrent Clostridioides difficile (C. " 01/13/2016 - "Fecal microbiota transplants (FMT) are an effective treatment for patients with gut microbe dysbiosis suffering from recurrent C. " 02/17/2022 - "Fecal microbiota transplantation (FMT) has been recognized as a promising treatment for dysbiosis-related diseases. "
3.	Transplantation 04/17/2015 - "Fecal-derived microbiota transplantation (FMT) can ameliorate the underlying dysbiosis and is highly effective for recurrent CDI. " 05/16/2022 - "butyricum-derived EVs restored gut dysbiosis and altered the relative abundance of Helicobacter, Escherichia-Shigella, Lactobacillus, Akkermansia and Bacteroides, which, in turn, faecal transplantations from EVs-treated mice relieved the symptoms of UC and improved the impact of EVs on the reprogramming of the M2 macrophages. " 01/01/2021 - "Although causality remains to be established, targeting dysbiosis of the intestinal microbiota by faecal microbiota transplantation (FMT) has been proposed as a novel treatment for inflammatory diseases. " 06/01/2013 - "Fecal microbial transplantation (FMT) is being proposed as a novel treatment for UC because it can eliminate dysbiosis; however, no prospective data exist. " 03/09/2022 - "A fecal microbial transplantation trial confirmed that KEC and ECP ameliorated UC by regulating gut dysbiosis. "
4.	Oral Administration 05/28/2019 - "For this purpose, we systematically reviewed the literature for randomised clinical trials (RCTs) in which the effect of oral administration of a mixture of four Lactobacillus strains (Lactobacillus crispatus LbV 88 (DSM 22566), Lactobacillus gasseri LbV 150N (DSM 22583), Lactobacillus jensenii LbV 116 (DSM 22567) and Lactobacillus rhamnosus LbV96 (DSM 22560)) on vaginal dysbiosis was examined based on Nugent score. " 08/14/2023 - "However, oral administration of CDE and CD restored gut microbiota dysbiosis. " 01/01/2023 - "Oral administration of MFXD altered microbiota dysbiosis in lung and AR-associated metabolic disorders. " 01/01/2023 - "Oral administration of the phage cocktail lowers Kp levels in Kp-colonized germ-free mice and SPF mice, without off-target dysbiosis. " 09/01/2022 - "The daily oral administration of MT to HF-fed dams during gestation and lactation reversed the dysbiosis of gut microbiota in both dams and adult offspring. "
5.	Drug Therapy (Chemotherapy) 10/01/2000 - "The article presents a summary of the published literature together with results of the author's own investigations designed to study pharmacotherapy of intestinal dysbacteriosis. " 12/01/2022 - "Paradoxically, cytotoxic chemotherapy may limit the therapeutic potential of ICB by significantly impairing the largest immune organ, the gastrointestinal (GI) tract, and driving gut microbial dysbiosis. " 01/01/2022 - "Chemotherapy adversely affects the gut microbiota, inducing dysbiosis, and negatively impacts gastrointestinal (GI) and psychosocial health during treatment, but little is known about the long-term effects or how these factors are related. " 12/01/2021 - "A proposed mechanism of GI toxicity includes chemotherapy-driven GI dysbiosis. " 07/30/2021 - "Our paper attempts to review the role of potential inflammatory and nutritional factors, as well as intestinal dysbiosis and pharmacotherapy, in the increased risk of CVD in IBD patients."