Intraocular Lymphoma

12/01/2010 - "Investigation of kinetics of methotrexate for therapeutic treatment of intraocular lymphoma."
09/01/2006 - "Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma."
09/01/2006 - "To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma. "
01/13/2022 - "Unusual presentation of cornea verticillata with intravitreal methotrexate in a case of primary intraocular lymphoma."
01/01/2022 - "Intravitreal methotrexate is an effective and repeatable treatment for intraocular lymphoma. "

04/10/2007 - "Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma."
11/01/2011 - "There is a growing amount of literature which suggests that rituximab may be useful for inflammatory ocular diseases and intraocular lymphoma. "
02/01/2009 - "Rituximab for intraocular lymphoma."
12/01/2007 - "Three patients (five eyes) with intraocular lymphoma were also treated with a 1 mg injection of rituximab. "
05/01/2006 - "The duration of time over which sustained levels of rituximab were achieved suggest that intravitreal administration warrants further investigation as an approach to treating vitreous and anterior chamber infiltrates in patients with primary intraocular lymphoma."

03/01/2009 - "A PCR that was performed twice was positive for intraocular lymphoma; a PPD was also strongly positive and the patient received anti-TB drugs as a first-line treatment, with complete resolution of all his ocular symptoms. "
09/01/2014 - "One patient is a 6-year-old child with intermediate uveitis and positive results for PPD, and the second is a 65-year-old woman with bilateral recurrent intraocular lymphoma. "

07/01/2012 - "Cytokine analysis of vitreous biopsy had the highest detection rate for intraocular lymphoma. "
07/01/2012 - "This retrospective study aimed to clarify the clinical features of patients diagnosed with intraocular lymphoma, and the diagnostic significance of results from analysis of vitreous samples including cytology, cytokine measurements, and the IgH gene rearrangement test. "
05/01/2009 - "Cytokine and molecular analyses of intraocular lymphoma."
05/01/2009 - "A combination of PCR assay to detect gene rearrangement of IgH and cytokine profiling (IL-10 and IL-6) is extremely useful for the diagnosis of intraocular lymphoma."
05/01/2009 - "Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid."

10/01/2011 - "After a short trial of topical and periocular steroids, diagnostic 25-gauge pars plana vitrectomy was performed and cytologic evaluation of the aspirate confirmed a diagnosis of intraocular lymphoma. "
09/01/2005 - "Cytological examination of rapidly transported, unfixed vitreous specimens is considered the gold standard in exclusion of primary intraocular lymphoma (PIOL) in patients with idiopathic steroid resistant chronic uveitis. "
03/01/2000 - "An initially unilateral and later bilateral uveitis in elderly patients which does not respond to steroid therapy could also be suspicious for an intraocular lymphoma. "
11/01/2022 - "Iris mass and uveitis which is not responsive to steroids may be ocular manifestations of intraocular lymphoma, such as NK cell lymphoma. "
08/01/2000 - "Because of the increased use of organ transplantation, eye care specialists should consider the diagnosis of intraocular lymphoma when confronted with uveitis-like syndrome unresponsive to topical steroid therapy. "

06/01/2003 - "Both patients developed recurrent CNS intraocular lymphoma and treatment involved intrathecal MTX and Ara-C delivered by means of an Ommaya reservoir. "
04/01/1986 - "Treatment of intraocular lymphoma with high-dose Ara-C."
06/01/2003 - "Both patients had previously undergone external beam radiation therapy to the orbit and brain, as well as systemic methotrexate (MTX) and intrathecal cytarabine (Ara-C), for primary CNS intraocular lymphoma. "
01/01/1993 - "In this report, a chemotherapy regimen, including high dose methotrexate and cytosine arabinoside, was used to re-induce remission in a patient with intraocular lymphoma relapsing locally after prior radiotherapy. "

09/01/2004 - "Treatment of primary intraocular lymphoma with oral trofosfamide: report of two cases and review of the literature."
12/01/2005 - "Pharmacokinetics and efficacy of ifosfamide or trofosfamide in patients with intraocular lymphoma."
06/01/2009 - "We evaluated response, progression-free survival (PFS), overall survival (OS), relapse patterns and long-term toxicity of intraocular lymphoma (IOL) patients treated with ifosfamide (IFO) or trofosfamide (TRO). "
06/01/2009 - "Ifosfamide or trofosfamide in patients with intraocular lymphoma."

08/01/2004 - "To report a case of primary intraocular lymphoma possessing bilaterally identical monoclonal rearrangements of the immunoglobulin heavy chain (IgH) gene. "
05/01/2009 - "The authors investigate the efficacy of using the cytokine levels and clonal heavy-chain immunoglobulin (IgH) gene rearrangements in the vitreous as adjunctive tools to diagnose intraocular lymphoma (IOL). "

12/01/2005 - "Pharmacokinetics and efficacy of ifosfamide or trofosfamide in patients with intraocular lymphoma."
06/01/2009 - "We evaluated response, progression-free survival (PFS), overall survival (OS), relapse patterns and long-term toxicity of intraocular lymphoma (IOL) patients treated with ifosfamide (IFO) or trofosfamide (TRO). "
06/01/2009 - "Ifosfamide or trofosfamide in patients with intraocular lymphoma."

07/01/2007 - "To determine the value of IL-10 measurement in aqueous humor (AH) for screening in primary intraocular lymphoma (PIOL). "
07/01/2007 - "IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma."
02/01/2005 - "The intraocular lymphoma cells produce high levels of IL-10, IFN-gamma, and CCR1 transcripts. "
01/01/1996 - " 3 IL-10 in the vitreous of patients with intraocular lymphoma. "
11/01/1995 - "Concentrations of interleukin-10 in the vitreous may be a helpful clue to both clinicians and pathologists in diagnosing primary intraocular lymphoma."

04/26/2010 - "To follow the changes in the electroretinograms (ERGs) in a patient with primary intraocular lymphoma (PIOL) who had a complete remission after chemotherapy. "
03/01/2023 - "En face OCT imaging can be considered for monitoring the therapeutic efficacy after intravitreal chemotherapy in intraocular lymphoma."
06/01/2003 - "Intrathecal chemotherapy for recurrent CNS intraocular lymphoma seems to be effective in preserving vision and possibly increasing survival."
04/01/1999 - "Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma appears effective in prolonging local remission of ocular disease even in the presence of an aggressively growing tumour. "
05/01/2008 - "To report the efficacy of intravitreal chemotherapy for primary intraocular lymphoma (PIOL). "

08/01/2000 - "Although there are numerous treatment options for intraocular lymphoma, radiation therapy was found to be effective in the treatment of this case."
01/01/2018 - "The study provides analysis of the long-term results of combined treatment of recurrent primary intraocular lymphoma including repeated courses of radiation therapy. "
01/01/2016 - "The aim of the study was to define indications for stereotactic radiotherapy (SRT) of primary intraocular lymphoma (PIOL) and to evaluate the SRT efficacy and toxicity level. "
01/01/2018 - "[Multi-session stereotactic radiotherapy in the treatment of recurrent B-cell primary intraocular lymphoma (a case report)]."
04/01/2014 - "Primary intraocular lymphoma: treatment outcomes with ocular radiation therapy alone."

08/01/2005 - "It is possible that insights gained from these studies will facilitate the development of targeted therapies, which address the fundamental genetic mutations that drive PCNSL and intraocular lymphoma growth."
01/01/2018 - "To describe clinical manifestations, diagnostic approaches, therapy, and outcomes of biopsy-proven intraocular lymphoma. "
04/01/2016 - "Intensive chemoimmunotherapy and bilateral globe irradiation as initial therapy for primary intraocular lymphoma."
11/01/2006 - "Human primary intraocular lymphoma (PIOL) is predominantly a B cell-originated malignant disease with no appropriate animal models and effective therapies available. "
12/13/2022 - "Primary intraocular lymphoma (PIOL) is a rare malignancy with a poor prognosis, but its optimal therapy remains unclear. "

01/01/2018 - "After six separate intravitreal injections of 400 mg/0.1 ml methotrexate, IVCM revealed a complete remission of intraocular lymphoma. "
01/01/2021 - "We describe the electroretinographic findings of a case of primary intraocular lymphoma (PIOL) wherein the patient received intravitreal injections of methotrexate (ivMTX). "
08/25/2018 - "Repetitive intravitreal injections of Methotrexate (MTX), a hydrophilic chemotherapeutic drug, are currently used to treat selected vitreoretinal (VR) diseases, such as intraocular lymphoma. "
08/01/2013 - "We report 2 cases of visually significant corneal epitheliopathy occurring after intravitreal injections of methotrexate for intraocular lymphoma. "
09/01/1997 - "To develop a protocol for the treatment of intraocular lymphoma by the intravitreal injection of methotrexate. "

11/01/2009 - "The purpose of this study is to report the role of whole-body 2-[(18)F] fluoro-2-deoxy-D-glucose (FDG) positron emission tomography fused with computed tomography (PET/CT) after immunocytochemical and clonal diagnosis of intraocular lymphoma with vitrectomy cell blocks. "
10/09/2023 - "Considering intraocular lymphoma as a potential diagnosis, the patient underwent a diagnostic vitrectomy. "
01/31/2023 - "Diagnostic Yield of In-Vitro Vitreous Biopsy for Intraocular Lymphoma at Variable Vitreous Cutter Speeds Using 25-Gauge Vitrectomy."
04/01/2019 - "Diagnostic vitrectomy with cytopathology evaluation is valuable, and concomitant FCI is useful to confirm intraocular lymphoma. "
12/01/2017 - "[Primary Intraocular Lymphoma: Relevance of Diagnostic Vitrectomy]."