Dodecenoyl-CoA Isomerase

A carbon-carbon double bond isomerase that catalyzes the movement double bond from C3 to C2 of an unsaturated acyl-CoA. The enzyme plays a key role in allowing acyl-CoA substrates to re-enter the beta-oxidation pathway.

Also Known As:

3,2-trans-Enoyl-CoA Isomerase; Acetylene-Allene Isomerase; Dodecenoyl-CoA delta-Isomerase; Dodecenoyl-Coenzyme A delta-Isomerase; Enoyl-CoA Isomerase; delta(3), delta(2)-Enoyl-CoA Isomerase; 3,2 trans Enoyl CoA Isomerase; Acetylene Allene Isomerase; Dodecenoyl CoA Isomerase; Dodecenoyl CoA delta Isomerase; Dodecenoyl Coenzyme A delta Isomerase; Enoyl CoA Isomerase; Isomerase, 3,2-trans-Enoyl-CoA; Isomerase, Acetylene-Allene; Isomerase, Dodecenoyl-CoA; Isomerase, Enoyl-CoA; delta-Isomerase, Dodecenoyl-CoA; delta-Isomerase, Dodecenoyl-Coenzyme A

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - Intramolecular Oxidoreductases
      - Carbon-Carbon Double Bond Isomerases
        Dodecenoyl-CoA Isomerase: 2
        Peroxisomal Bifunctional Enzyme: 18
        human ECI1 protein
        human ECI2 protein
        mouse Eci1 protein
        mouse Eci2 protein

Experts

1.	Belisle, Sarah E: 1 article (11/2011)
2.	Carter, Victoria S: 1 article (11/2011)
3.	Diamond, Deborah L: 1 article (11/2011)
4.	Gao, Xiaoli: 1 article (11/2011)
5.	Katze, Michael G: 1 article (11/2011)
6.	Korth, Marcus J: 1 article (11/2011)
7.	Matzke, Melissa M: 1 article (11/2011)
8.	McDermott, Jason E: 1 article (11/2011)
9.	Metz, Thomas O: 1 article (11/2011)
10.	Rasmussen, Angela L: 1 article (11/2011)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 12/01/1997 - "Characterization of S-hexylglutathione-binding proteins of human hepatocellular carcinoma: separation of enoyl-CoA isomerase from an Alpha class glutathione transferase form." 12/01/1997 - "Recent studies have revealed binding of mitochondrial enoyl-CoA isomerase (ECI) to S-hexylglutathione-Sepharose, an affinity matrix used for purification of glutathione transferases (GSTs), and the enzyme has been suggested to be identical with the Alpha class form of GST with a subunit molecular mass of about 30 kDa. In the present study, S-hexylglutathione-binding proteins of human hepatocellular carcinomas were characterized to examine their identity. "
2.	Infections 11/01/2011 - "We previously employed systems biology approaches to identify the mitochondrial fatty acid oxidation enzyme dodecenoyl coenzyme A delta isomerase (DCI) as a bottleneck protein controlling host metabolic reprogramming during hepatitis C virus (HCV) infection. "

Related Drugs and Biologics

1.	Enzymes
2.	Glutathione Transferase (Glutathione S-Transferase)
3.	Carrier Proteins (Binding Protein)
4.	O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfate
5.	S-hexylglutathione-sepharose
6.	hexylglutathione
7.	Proteins (Proteins, Gene)
8.	Fatty Acids (Saturated Fatty Acids)