Organophosphonates (Phosphonates)

Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.

Also Known As:

Networked: 424 relevant articles (31 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	De Clercq, Erik: 12 articles (07/2016 - 10/2002)
2.	Holý, Antonín: 12 articles (01/2012 - 08/2003)
3.	Hostetler, Karl Y: 8 articles (01/2018 - 10/2006)
4.	Zheng, Li-Min: 7 articles (10/2019 - 11/2008)
5.	Beadle, James R: 7 articles (01/2018 - 10/2006)
6.	Bao, Song-Song: 5 articles (10/2019 - 02/2011)
7.	Andrei, Graciela: 5 articles (01/2019 - 07/2007)
8.	Snoeck, Robert: 5 articles (01/2019 - 07/2007)
9.	Fang, Jim-Min: 5 articles (01/2016 - 10/2007)
10.	Votruba, Ivan: 5 articles (09/2010 - 11/2003)

Related Diseases

1.	Infections 02/22/2023 - "The results obtained in this study demonstrated that K-phosphonate could contain the development of Phytophthora infection in phloem tissues. " 05/01/2020 - "The median estimated effective concentration required to reduce infection by 50% (EC50) for isolates collected from two farms reporting disease control failures was 2.7% (vol/vol) phosphonate (range = 1.6 to 164.2), which was 1.6 times (range = 0.9 to 96.0) the maximum labeled rate of the phosphonate fungicide utilized. " 09/01/2014 - "We show that this newly synthesized compound suppressed HIV-1 infection in lymphoid tissue ex vivo more efficiently than did other phosphonates of NRTIs. " 11/22/2023 - "Finally, the results of quantum chemical study supported the binding mode obtained from the docking study performed inside the active site of MurA (PDB: 1UAE), suggesting that these phosphonates may be promising safe candidates for MDR infection therapy clinical trials with no toxic effects on the normal human cells." 05/25/2021 - "The review comprises [67Ga]Ga-citrate, radiolabelled leukocytes, radiolabelled nanocolloids (bone marrow) and radiolabelled phosphonates (bone structure), and [18F]FDG as established radiotracers for bone marrow infection imaging. "
2.	Retroviridae Infections (Infection, Retrovirus) 01/01/2017 - "Acyclic nucleoside phosphonates (ANPs) are nowadays one of the key drugs in the treatment of DNA virus and retrovirus infections. " 06/01/2003 - "Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections." 01/01/1998 - "Acyclic nucleoside phosphonates: a new dimension to the chemotherapy of DNA virus and retrovirus infections." 01/01/1997 - "Acyclic nucleoside phosphonates in the chemotherapy of DNA virus and retrovirus infections." 11/01/2005 - "Almost 20 years after the broad antiviral activity spectrum of the first acyclic nucleoside phosphonates was described, several of these compounds have become important therapies for DNA virus and retrovirus infections. "
3.	Pain (Aches) 01/01/2018 - "Although various treatment modalities are available for bone pain palliation, use of radiolabeled phosphonates is documented to be more effective. " 06/18/2009 - "Design of effective AChE reactivators as antidotes to various organophosphonates requires information on how the reactivators interact with the phosphonylated AChEs. " 04/01/2013 - "Analogs with Z=Br, I, or OTs were weak inhibitors of the AChEs, and methyl phosphonates (R=Me) were more potent than the corresponding ethyl phosphonates (R=Et). " 09/01/2008 - "A review about some of the non-specific targeting molecules with therapeutic or pain palliation effect such as phosphonates, lipiodol, microparticles and other interesting molecules is included. " 07/01/2016 - "Various phosphonate ligands labeled with β--emitting radionuclides have shown good efficacy for bone pain palliation. "
4.	Papilloma (Papillomatosis) 10/01/1999 - "To assess the potential benefit of intralesional administration of cidofovir, an acyclic nucleoside phosphonate with activity against several DNA viruses, for treating severe respiratory papillomas in pediatric patients. " 01/01/1997 - "The acyclic nucleoside phosphonates [HPMPC (cidofovir), PMEA (adefovir) and PMPA] have proved to the effective in vitro (cell culture systems) and in vivo (animal models, clinical studies) against a wide variety of DNA virus and retrovirus infections: i.e., HPMPC against herpesvirus (herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, human herpesvirus types 6, 7, and 18), polyoma-, papilloma-, adeno-, and poxvirus (vaccinia virus, molluscum contagiosum virus) infections; PMEA against herpesvirus, hepadnavirus (human hepatitis B virus) and retrovirus (human immunodeficiency virus type 1 and 2, simian immunodeficiency virus, and feline immunodeficiency virus) infections; and PMPA against both hepadna- and retrovirus infections." 06/01/2003 - "The acyclic nucleoside phosphonates [HPMPC: cidofovir, Vistide; PMEA: adefovir dipivoxil, Hepsera; and PMPA: tenofovir, Viread] have proven to be effective in vitro (cell culture systems) and in vivo (animal models and clinical studies) against a wide variety of DNA virus and retrovirus infections, for example, cidofovir against herpesvirus [herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, human herpesvirus type 6, 7 and 8), polyoma-, papilloma-, adeno- and poxvirus (variola virus, cowpox virus, vaccinia virus, molluscum contagiosum virus and orf) infections; adefovir against herpesvirus, hepadnavirus [human hepatitis B virus] and retrovirus [HIV type-1 and 2, simian immunodeficiency virus and feline immunodeficiency virus] infections; and tenofovir against both hepadna- and retrovirus infections. " 11/01/2005 - "Here, we review the discovery and development of acyclic nucleoside phosphonates, focusing on cidofovir and its potential in the treatment of various herpes-, papilloma-, polyoma-, adeno- and pox-virus infections, adefovir for the treatment of hepatitis B and tenofovir for the treatment of AIDS and the prevention of HIV infections." 04/01/2007 - "Nature 1986;323:464-7], the acyclic nucleoside phosphonates have acquired a prominent therapeutic position: (i) cidofovir in the treatment of papilloma-, herpes-, adeno- and poxvirus infections, (ii) adefovir in the treatment of chronic hepatitis B virus (HBV) infections, and (iii) tenofovir in the treatment of human immunodeficiency virus (HIV) infections (AIDS). "
5.	HIV Infections (HIV Infection) 07/01/2013 - "AZT 5'-Phosphonates: Achievements and Trends in the Treatment and Prevention of HIV Infection." 12/01/2008 - "To determine if this strategy would be effective for certain phosphonomethoxyethyl nucleoside phosphonates which are also active against HIV infections, the hexadecyloxypropyl (HDP) esters of 1-(phosphonomethoxyethyl)-cytosine, 1-(phosphonomethoxyethyl)-5-bromo-cytosine (PME-5BrC), 1-(phosphonomethoxyethyl)-5-fluoro-cytosine, 9-(phosphonomethoxyethyl)-2,6-diaminopurine (PME-DAP), and 9-(phosphonomethoxyethyl)-2-amino-6-cyclopropylaminopurine (PME-cPrDAP) were evaluated for activity against herpesvirus replication. " 01/01/1998 - "High expectations are vested in the acyclic nucleoside phosphonates PMEA and PMPA (which have proved clearly efficacious against HIV infections in phase II/III and phase I/II trials, respectively) and the bicyclam derivatives, which have recently been shown to block HIV infection through interference with the viral co-receptor CXCR4 (fusin). " 12/01/2001 - "Development of a novel group of antiviral agents, acyclic nucleoside phosphonates, has provided a new perspective for treating human immunodeficiency virus (HIV) infection. " 01/01/2007 - "In present experiments we analyzed effects of acyclic nucleoside phosphonates on gene expression of other members of the beta family of chemokines, monocyte chemotactic proteins (MCPs), which have also been implicated in the control of HIV infection. "

Related Drugs and Biologics

1.	Nucleosides
2.	Cidofovir (Vistide)
3.	adefovir
4.	Tenofovir (Viread)
5.	Ligands
6.	Nucleotides
7.	Antiviral Agents (Antivirals)
8.	Radioisotopes (Radionuclides)
9.	Samarium-153
10.	Radiopharmaceuticals

Related Therapies and Procedures

1.	Chemoprevention
2.	Therapeutics
3.	Palliative Care (Palliative Therapy)
4.	Drug Therapy (Chemotherapy)
5.	Microspheres (Microsphere)