Epithelial Sodium Channel Blockers

A subclass of sodium channel blockers that are specific for EPITHELIAL SODIUM CHANNELS.

Also Known As:

ENaC Channel Blockers; Epithelial Sodium Channel Antagonists; Epithelial Sodium Channel Inhibitors; Renal Epithelial Sodium Channel Blockers; Renal Epithelial Sodium Channel Inhibitors; Channel Blockers, ENaC; Epithelial Sodium Ion Channel Blockers

Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Membrane Transport Modulators
      - Sodium Channel Blockers: 584
        Epithelial Sodium Channel Blockers: 8
  - Physiological Effects of Drugs: 1
    - Natriuretic Agents: 476
      - Diuretics: 14807
        Potassium Sparing Diuretics: 143
        Epithelial Sodium Channel Blockers: 8

Experts

1.	Abdalla, Marwah: 1 article (01/2021)
2.	Brock, Guy: 1 article (01/2021)
3.	Echouffo-Tcheugui, Justin B: 1 article (01/2021)
4.	Effoe, Valery S: 1 article (01/2021)
5.	Golden, Sherita H: 1 article (01/2021)
6.	Hsueh, Willa A: 1 article (01/2021)
7.	Joseph, Joshua J: 1 article (01/2021)
8.	Kalyani, Rita R: 1 article (01/2021)
9.	Kline, David: 1 article (01/2021)
10.	Kluwe, Bjorn: 1 article (01/2021)

Related Diseases

1.	Liddle Syndrome 01/01/2020 - "They were each subsequently found with the same genetic mutation of SCNN1B consistent with Liddle syndrome and started on epithelial sodium channel inhibitors with improvement in their blood pressure. "
2.	Hypertension (High Blood Pressure) 01/01/2021 - "Further clinical investigation of novel and approved medications that target low renin physiology such as epithelial sodium channel inhibitors and mineralocorticoid receptor antagonists may be paramount in improving hypertension control in African Americans." 01/01/2017 - "Liddle's syndrome, an autosomal dominant form of monogenic hypertension, is characterized by salt-sensitive hypertension with early penetrance, hypokalemia, metabolic alkalosis, suppression of plasma rennin activity and aldosterone secretion, and a clear-cut response to epithelial sodium channel blockers but not spironolactone therapy. " 03/01/2007 - "The diuretics include a) the thiazides and thiazide-like agents, which are the most common drugs used to treat high blood pressure (these drugs inhibit sodium reabsorption in the early distal convoluted tubule); b) loop diuretics, such as furosemide, block chloride and sodium reabsorption by inhibition of the Na/K/2Cl cotransport system in the thick ascending limb of the loop of Henle; and c) potassium-sparing (retaining) diuretics, including aldosterone receptor blockers (such as spironolactone and eplerenone) and epithelial sodium channel blockers (such as amiloride and triamterene, which interfere with the reabsorption of sodium and excretion of potassium and hydrogen that takes place in the late distal tubule, the connecting tubule, and the cortical collecting duct). "
3.	Cystic Fibrosis (Mucoviscidosis) 10/01/2013 - "Novel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation." 07/13/2006 - "Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis."
4.	Chronic Bronchitis 07/13/2006 - "Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis."
5.	Cardiac Sudden Death (Sudden Cardiac Arrest) 09/01/2008 - "Treatment of elderly hypertensive patients with epithelial sodium channel inhibitors combined with a thiazide diuretic reduces coronary mortality and sudden cardiac death."

Related Drugs and Biologics

1.	Spironolactone (Aldactone)
2.	Triamterene (Dyrenium)
3.	Amiloride (Midamor)
4.	Eplerenone (Inspra)
5.	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)
6.	Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)
7.	Thiazides
8.	Mineralocorticoid Receptors (Mineralocorticoid Receptor)
9.	Sodium
10.	Salts

Related Therapies and Procedures

1.	Therapeutics