NAV1.4 Voltage-Gated Sodium Channel

A voltage-gated sodium channel subtype that mediates the sodium ion PERMEABILITY of SKELETAL MYOCYTES. Defects in the SCN4A gene, which codes for the alpha subunit of this sodium channel, are associated with several MYOTONIC DISORDERS.

Also Known As:

NAV1.4 alpha Subunit; SCN4A Sodium Channel alpha Subunit; Sodium Channel, Voltage-Gated, Type IV, alpha 1 Subunit; Type 4 Voltage-Gated Sodium Channel; Voltage-Gated Sodium Channel Type 4; NAV1.4 Voltage Gated Sodium Channel; Subunit, NAV1.4 alpha; Type 4 Voltage Gated Sodium Channel; Voltage Gated Sodium Channel Type 4; Voltage Gated Sodium Channel Type 4 Subunit alpha; alpha Subunit, NAV1.4; Voltage-Gated Sodium Channel Type 4 Subunit alpha

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cui, Shilei: 1 article (01/2022)
2.	Li, Ying: 1 article (01/2022)
3.	Meng, Lingchao: 1 article (01/2022)
4.	Nagasaka, Takamura: 1 article (01/2022)
5.	Nan, Haitian: 1 article (01/2022)
6.	Sun, Houliang: 1 article (01/2022)
7.	Wang, Jiawei: 1 article (01/2022)
8.	Wu, Liyong: 1 article (01/2022)
9.	Wu, Yunqing: 1 article (01/2022)
10.	Acevedo-Arozena, Abraham: 1 article (12/2014)

Related Diseases

1.	Paralysis (Palsy) 12/01/2014 - "Mutations in the skeletal muscle channel (SCN4A), encoding the Nav1.4 voltage-gated sodium channel, are causative of a variety of muscle channelopathies, including non-dystrophic myotonias and periodic paralysis. " 01/07/2022 - "Mutations in the transient sodium channel Nav1.4 alpha subunit (SCN4A) gene underlie a diverse group of dominantly inherited nondystrophic myotonias that run the spectrum from subclinical myopathy to severe muscle stiffness, disabling weakness, or frank episodes of paralysis. "
2.	Myotonia 12/01/2014 - "Mutations in the skeletal muscle channel (SCN4A), encoding the Nav1.4 voltage-gated sodium channel, are causative of a variety of muscle channelopathies, including non-dystrophic myotonias and periodic paralysis. " 01/07/2022 - "Mutations in the transient sodium channel Nav1.4 alpha subunit (SCN4A) gene underlie a diverse group of dominantly inherited nondystrophic myotonias that run the spectrum from subclinical myopathy to severe muscle stiffness, disabling weakness, or frank episodes of paralysis. "
3.	Channelopathies 12/01/2014 - "Mutations in the skeletal muscle channel (SCN4A), encoding the Nav1.4 voltage-gated sodium channel, are causative of a variety of muscle channelopathies, including non-dystrophic myotonias and periodic paralysis. "
4.	Muscular Diseases (Myopathy) 01/07/2022 - "Mutations in the transient sodium channel Nav1.4 alpha subunit (SCN4A) gene underlie a diverse group of dominantly inherited nondystrophic myotonias that run the spectrum from subclinical myopathy to severe muscle stiffness, disabling weakness, or frank episodes of paralysis. "
5.	Potassium aggravated myotonia 11/18/2008 - "A novel dominant mutation of the Nav1.4 alpha-subunit domain I leading to sodium channel myotonia."

Related Drugs and Biologics

1.	Sodium Channels (Sodium Channel)