Claudin-4

A claudin subtype that takes part in maintaining the barrier-forming property of TIGHT JUNCTIONS. Claudin-4 is found associated with CLAUDIN-8 in the KIDNEY COLLECTING DUCT where it may play a role in paracellular chloride ion reabsorption.

Also Known As:

Networked: 425 relevant articles (14 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sawada, Norimasa: 17 articles (10/2018 - 12/2004)
2.	Kojima, Takashi: 16 articles (01/2019 - 12/2004)
3.	Kondoh, Masuo: 13 articles (06/2022 - 01/2006)
4.	Kuniyasu, Hiroki: 9 articles (06/2022 - 12/2015)
5.	Morin, Patrice J: 9 articles (01/2011 - 07/2003)
6.	Luo, Yi: 8 articles (06/2022 - 12/2015)
7.	Himi, Tetsuo: 8 articles (01/2019 - 12/2004)
8.	Santin, Alessandro D: 8 articles (01/2019 - 10/2004)
9.	Murata, Masaki: 8 articles (10/2018 - 12/2004)
10.	Fujiwara-Tani, Rina: 7 articles (06/2022 - 12/2018)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2021 - "Our study demonstrates that the expression of claudin-4 is significantly higher in UBC compared to BBC tumors. " 10/01/2016 - "This is the first study to show how TGF-β regulates the expression of Claudin-4 through c-Jun signaling and how this pathway contributes to the migratory and tumorigenic phenotype of lung tumor cells." 09/01/2012 - "This review describes and discusses the studies targeting claudin-4 in normal human pancreatic duct epithelial (HPDE) cells and cancer cells. " 01/01/2024 - "In cases signed out as inconclusive encompassing atypia of undetermined significance (AUS) and suspicious for malignancy (SFM) and negative for malignancy, change in diagnostic category based on addition of claudin-4 ICC was assessed. " 03/01/2023 - "Claudin-4 was positive in all serous tumors and negative in all PM. "
2.	Carcinoma (Carcinomatosis) 01/01/2023 - "Claudin4 is a new marker with promising results; however, further studies are required to establish its role as a pan-carcinoma marker in serous effusions. " 12/01/2009 - "These results suggest that low claudin-4 expression in epitheliomas is a molecular characteristic indicative of increasing cellular disorientation, detachment motility and invasion by tumour cells, and claudin-4 seems to be helpful in distinguishing undifferentiated carcinomas from differentiated carcinomas and epitheliomas of the hepatoid gland. " 08/01/2018 - "The aim of this study was to examine claudin-4 expression in UECs/DDECs and other high-grade uterine carcinomas. " 07/06/2012 - "In this study, we aimed to determine the role of Twist1 in the regulation of claudin-4 expression and investigate its specific mechanisms and clinical implications using human esophageal carcinoma cell lines and tissues. " 01/01/2023 - "Claudin-4 and MOC-31 both demonstrated significant diagnostic value in distinguishing metastatic epithelial carcinoma from reactive mesothelium. "
3.	Adenocarcinoma 01/01/2023 - "This study aimed to determine the utility of Claudin4 in diagnosing metastatic adenocarcinoma in effusions and comparing its performance with BerEp4. " 10/01/2022 - "In this study, we analyzed the immunoexpression of Claudin 4 in 58 cases of gastric adenocarcinomas, in relation to the main histopathological parameters of aggressiveness, the reactions obtained being evaluated through the intensity of the reactions and the number of positive cells. " 01/01/2024 - "Claudin-4 as a single marker is sensitive and specific for adenocarcinoma and is a valuable addition to the ICC armamentarium." 01/01/2024 - "Among cases with confirmed serosal involvement status on follow-up, claudin-4 showed sensitivity, specificity, positive predictive value and negative predictive values of 85% (11/13), 100% (3/3), 100% (10/10) and 75% (3/4), respectively, for metastatic adenocarcinoma. " 01/01/2023 - "Claudin4 immunohistochemistry (IHC) was performed on effusion cell blocks (n = 60) reported as positive or suspicious for metastatic adenocarcinoma on cytology over a 1-year period and was scored for intensity (0-3) and percentage of positive cells (0-4). "
4.	Ovarian Neoplasms (Ovarian Cancer) 04/01/2011 - "Claudin-4 expression was significantly greater in ovarian cancer tissue from chemoresistant patients compared to chemosensitive patients. " 10/01/2019 - "Claudin-4 might be involved in the molecular mechanisms underlying how MLH1 influences survival and chemosensitivity in patients with ovarian cancer." 12/15/2011 - "CD44(+) ovarian cancer stem cells expressed claudin-4 gene at significantly higher levels than matched autologous CD44(-) ovarian cancer cells, and regardless of their higher resistance to chemotherapeutic agents died within 1 hour after exposure to 1.0 μg/mL of CPE in vitro. " 12/15/2011 - "During the characterization of CD44(+) ovarian cancer stem cells, we found a high expression of the genes encoding for claudin-4. " 04/01/2011 - "Claudin-4 expression in ovarian cancer tissue resected from the patients surgically was evaluated immunohistochemically. "
5.	Mesothelioma 01/01/2020 - "Claudin-4 stained 0 of 68 (0%), MOC-31 stained 22 of 68 (32%), and Ber-EP4 stained 24 of 68 (35%) epithelioid mesotheliomas; thus, the specificities for NSCLC versus epithelioid mesothelioma were 100%, 68%, and 65%, respectively. " 11/01/2019 - "Only 1/63 (1.6%) mesotheliomas was positive for claudin-4. " 04/01/2014 - "All cases of mesothelioma were negative for claudin-4 (0 of 64). " 10/01/2013 - "All mesothelioma specimens were negative for claudin-4, but 3 of 18 specimens were focally positive for Ber-EP4. " 05/01/2013 - "Value of claudin-4 immunostaining in the diagnosis of mesothelioma."

Related Drugs and Biologics

1.	Occludin
2.	Cisplatin (Platino)
3.	Claudin-1
4.	Monoclonal Antibodies
5.	Interleukin-6 (Interleukin 6)
6.	Caspase 3 (Caspase-3)
7.	Fatty Acid-Binding Proteins
8.	12,13- dihydro- N- methyl- 6,11,13- trioxo- 5H- benzo(4,5)cyclohepta(1,2- b)naphthalen- 5,12- imine
9.	fucoidan
10.	Claudin-3

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Adjuvant Chemotherapy
5.	Lasers (Laser)