Long Noncoding RNA

A class of untranslated RNA molecules that are typically greater than 200 nucleotides in length and do not code for proteins. Members of this class have been found to play roles in transcriptional regulation, post-transcriptional processing, CHROMATIN REMODELING, and in the epigenetic control of chromatin.

Also Known As:

RNA, Long Noncoding; LINC RNA; LincRNAs; Long Intergenic Non-Protein Coding RNA; Long Non-Coding RNA; Long Non-Protein-Coding RNA; Long ncRNA; Long ncRNAs; RNA, Long Non-Translated; lncRNA; Long Intergenic Non Protein Coding RNA; Long Non Coding RNA; Long Non Protein Coding RNA; Long Non-Translated RNA; Long Untranslated RNA; Non-Coding RNA, Long; Non-Protein-Coding RNA, Long; Non-Translated RNA, Long; Noncoding RNA, Long; RNA, Long Non Translated; RNA, Long Non-Coding; RNA, Long Non-Protein-Coding; Untranslated RNA, Long; ncRNA, Long; ncRNAs, Long; LincRNA; RNA, Long Untranslated

Networked: 25871 relevant articles (250 outcomes, 5315 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - RNA: 69704
    - Untranslated RNA: 2850
      - Long Noncoding RNA: 25871
        XIST non-coding RNA: 125
        Miat long non-coding RNA: 97
        H19 long non-coding RNA: 45
        steroid receptor RNA activator: 41
        human MIR17HG: 2
        human AA174084 non-coding RNA: 1
        human LINC00312 long non-coding RNA: 1
        mouse FTX lncRNA: 1
        Arabidopsis COLDWRAP long noncoding RNA
        Arabidopsis R8 long non-coding RNA
        Drosophila acal long non-coding RNA
        Drosophila lncRNA:noe
        Drosophila yar RNA
        E coli CsrB RNA
        E coli CsrC RNA
        ENOD40 RNA
        human 17A non-coding RNA
        human AATBC long noncoding RNA
        human AC132217.4 long noncoding RNA
        human AF339813 long non-coding RNA
        human AFAP1-AS1 long noncoding RNA
        human AK124742 long non-coding RNA
        human AK127244 long non-coding RNA
        human ANCR long noncoding RNA
        human ATXN8OS gene product
        human BACE1-AS long non-coding RNA
        human BALR-6 non-coding RNA
        human BANCR long non-coding RNA
        human BCAR4 non-coding RNA
        human BLACE lncRNA
        human boundary associated long noncoding RNA-1
        human BPESC1 lncRNA
        human CAHM long non-coding RNA
        human CASC8 lncRNA
        human CCAT1 long noncoding RNA
        human CDKN2B antisense RNA
        human CEBPA-DT long noncoding RNA
        human CHRF long noncoding RNA
        human CLLU1 lncRNA
        human CLMAT3 long noncoding RNA
        human CONCR long non coding RNA
        human CRNDE RNA
        human CTD-2541M15 long noncoding RNA
        human DANCR long noncoding RNA
        human DINOL lncRNA
        human DIRC1 lncRNA
        human DISC1FP1 non-coding RNA
        human DISC2 gene product
        human DLEU1 lncRNA
        human DLEU2 lncRNA
        human DSCR4 lncRNA
        human EGOT lncRNA
        human EPB41L4A-AS1 lncRNA
        human ERC2-IT1 lncRNA
        human ESRG lncRNA
        human estrogen receptor repressor-10
        human FAM201A long noncoding RNA
        human FAM230A lncRNA
        human focally amplified long noncoding RNA on chromosome 1
        human FOXP4 antisense RNA 1
        human GAS5 long non-coding RNA
        human GAS8-AS1 protein
        human GHET1 transcript
        human GSC-DT lncRNA
        human HBL1 long noncoding RNA
        human HCG9 non-protein coding RNA
        human HCP5 long noncoding RNA
        human HELLP long non-coding RNA
        human HIF1A-AS1 long non-coding RNA
        human HOTAIR long untranslated RNA
        human HULC long non-coding RNA
        human Khps1 long noncoding RNA
        human LEIGC long non-coding RNA
        human linc-md1 long noncoding RNA
        human Linc-RNA-RoR
        human linc-VLDLR long noncoding RNA
        human LINC00237 RNA
        human LINC00273 lncRNA
        human LINC00339 long noncoding RNA
        human LINC00342 long noncoding RNA
        human LINC00461 lncRNA
        human LINC00472 RNA
        human LINC00473 RNA
        human LINC00491 long noncoding RNA
        human LINC00539 lncRNA
        human LINC00857 lnc
        human LINC00978 long noncoding RNA
        human LINC01296 long non-coding RNA
        human linc0597 long non-coding RNA
        human LINK-A long non-coding RNA
        human LINP1 non-coding RNA
        human lnc-DC long non-coding RNA
        human lncRNA ADAMTS9-AS2
        human lncRNA LNMAT1
        human lncRNA LOC100129973
        human lncRNA LOC553103
        human LncRNA-HOST2
        human LOC101926975 long non-coding RNA
        human LOC105372760 lncRNA
        human loc285194 LncRNA

Experts

1.	Zhang, Wei: 146 articles (11/2022 - 01/2013)
2.	Wang, Wei: 130 articles (08/2022 - 04/2013)
3.	Wang, Yan: 107 articles (12/2022 - 01/2015)
4.	Zhang, Yan: 101 articles (10/2022 - 01/2014)
5.	Li, Wei: 101 articles (08/2022 - 05/2012)
6.	Wang, Jing: 96 articles (12/2022 - 11/2014)
7.	Chen, Wei: 95 articles (09/2022 - 03/2012)
8.	Zhang, Lei: 93 articles (09/2022 - 01/2014)
9.	Li, Li: 93 articles (01/2022 - 01/2016)
10.	Li, Jun: 89 articles (01/2022 - 02/2011)

Related Diseases

1.	Neoplasms (Cancer) 03/15/2016 - "Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA. " 06/01/2019 - "Continuous studies in lncRNA functional discrepancy between cancer cells and normal cells and regional and rational genetic differences of lncRNA profiles are critical for clinical research which is beneficial for clinical practice." 01/01/2022 - "Risk scores of lncRNA prognostic signature, related to autophagy helped in distinguishing the patients accurately among the low-risk and high-risk RCC based on age, sex, grade of tumor, T, M, N, and AJCC stages. " 12/14/2021 - "Clarification of the lincRNA genomic clusters specific roles in human cancers could be beneficial for understanding the molecular pathogenesis of different cancer types." 05/31/2016 - "Here, we performed comprehensive analysis for lncRNA expression profiles and clinical data of 544 OvCa patients from The Cancer Genome Atlas (TCGA), and identified an eight-lncRNA signature with ability to classify patients of the training cohort into high-risk group showing poor outcome and low-risk group showing significantly improved outcome, which was further validated in the validation cohort and entire TCGA cohort. "
2.	Inflammation (Inflammations) 12/01/2021 - "Further gain- and loss-of-function experiments evidenced that both LncRNA MALAT1 ablation and miRNA-135b-5p overexpression reversed LPS-induced cell pyroptosis, apoptosis, and inflammation in the HK-2 cells, and the protective effects of LncRNA MALAT1 knock-down on LPS-treated HK-2 cells were abrogated by silencing miRNA-135b-5p. " 11/01/2022 - "LncRNA TM1-3P improved inflammation and damage of knee joints in OA rats through miR-144-3p/ONECUT2 axis, providing a new theoretical basis for gene therapy of OA." 10/01/2019 - "Our study suggests that the downregulated lncRNA UCA1 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in PD rats through the inhibition of the PI3K/Akt signaling pathway." 06/01/2023 - "Rescue assays illustrated that lncRNA SNHG14 knockdown relieved FFA-induced adipocyte ER stress and inflammation through miR-497a-5p/BACE1. " 08/01/2022 - "Collectively, our findings evidenced that upregulation of lncRNA H19 attenuates inflammation and ameliorates cartilage damage and chondrocyte apoptosis in OA by upregulating TP53, IL-38, and by activating IL-36R.Cite this article: Bone Joint Res 2022;11(8):594-607."
3.	Myocardial Infarction 02/01/2020 - "LncRNA MALAT1 prevents the protective effects of miR-125b-5p against acute myocardial infarction through positive regulation of NLRC5." 12/01/2019 - "Cardiac autophagy inhibitory factor (CAIF) is a novel lncRNA with protective effects on myocardial infarction. " 06/01/2023 - "LncRNA H19 ameliorates myocardial infarction-induced myocardial injury and maladaptive cardiac remodelling by regulating KDM3A." 01/01/2022 - "lncRNA NEAT1 Downregulation Ameliorates the Myocardial Infarction of Mice by Regulating the miR-582-5p/F2RL2 Axis." 01/01/2021 - "Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction via MIAT/miR-10a-5p/EGR2 axis."
4.	Myocardial Ischemia (Ischemic Heart Diseases) 07/15/2022 - "This study explored if the upregulated P2Y12 receptor in SCGs was relevant to lncRNA uc.48+ during myocardial ischemia (MI). " 05/01/2022 - "In the present study, the role of lncRNA SNHG1 in myocardial ischemia reperfusion injury (MIRI) and the underlying mechanisms were investigated. " 01/01/2021 - "Herein, we performed a study to explore the effect of lncRNA PART1 on myocardial ischemia-reperfusion (I/R) injury by targeting BIRC5 through miR-503-5p pathway. " 01/01/2020 - "Study has indicated lncRNA ROR aggravates myocardial ischemia/reperfusion (I/R) injury. " 10/01/2022 - "We aimed to elucidate the function of lncRNA FGD5-AS1 and the regulatory mechanism of lncRNA FGD5-AS1/miR-129-5p in myocardial ischemia-reperfusion (I/R) injury. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level. " 11/02/2023 - "Prognostic value of lncRNA AFAP1-AS1 in breast cancer: a meta-analysis and validated study in Chinese population." 07/21/2023 - "Bridging Pyroptosis and Immunity: A Comprehensive Study of the Pyroptosis-Related Long Non-Coding RNA Signature in Breast Cancer." 01/01/2023 - "In this study, we found that lncRNA sprouty4-intron transcript 1 (SPRY4-IT1) was regulated by PDK1 with correlation analysis, and PDK1 upregulated SPRY4-IT1 remarkably in breast cancer cells, as PDK1 interacted with SPRY4-IT1 in the nucleus and significantly enhanced the stability of SRPY4-IT1. Furthermore, SPRY4-IT1 was highly expressed in breast cancer, significantly promoted the proliferation and inhibited apoptosis of breast cancer cells. " 01/01/2023 - "In this study, we explored the role of lncRNA BC069792 in breast cancer. "

Related Drugs and Biologics

1.	Long Noncoding RNA
2.	MicroRNAs (MicroRNA)
3.	Messenger RNA (mRNA)
4.	Biomarkers (Surrogate Marker)
5.	Competitive Endogenous RNA
6.	Sirtuin 1
7.	Proteins (Proteins, Gene)
8.	Cisplatin (Platino)
9.	Glucose (Dextrose)
10.	Catenins

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Neoadjuvant Therapy
4.	Drug Therapy (Chemotherapy)
5.	Radiotherapy