LncRNA CAIF was downregulated in end-stage cardiomyopathy and is a promising diagnostic and prognostic marker for this disease.

Abstract

Cardiac autophagy inhibitory factor (CAIF) is a novel lncRNA with protective effects on myocardial infarction. We explored the involvement of CAIF in end-stage cardiomyopathy. Patients with end-stage cardiomyopathy and healthy volunteers were included in this study. Myocardial tissues and serum were collected. CAIF was detected by RT-qPCR. ROC curve was used for diagnostic analysis. Prognostic value of CAIF expression for end-stage cardiomyopathy was evaluated by survival curve analysis. Correlations between CAIF expression and clinicopathological data of patients with end-stage cardiomyopathy were analysed by chi-square test. Downregulated CAIF was observed in end-stage cardiomyopathy patients than in healthy controls. CAIF expression distinguished end-stage cardiomyopathy patients from healthy controls and predict the survival of patients. LncRNA CAIF was downregulated in end-stage cardiomyopathy and may serve as a promising prognostic and diagnostic marker for this disease.

• Authors: Di Wu, Yanqiu Zhou, Yudong Fan, Qingjun Zhang, Feifei Gu, Wen Mao, Miaomiao Zhang
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 24 Issue 8 Pg. 735-738 (Dec 2019) ISSN: 1366-5804 [Electronic] England
• PMID: 31587591 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• RNA, Long Noncoding

Topics

• Autophagy (drug effects)
• Biomarkers (analysis)
• Cardiomyopathies (diagnosis, genetics, pathology)
• Case-Control Studies
• Humans
• Prognosis
• RNA, Long Noncoding (analysis, metabolism, pharmacology)