Disease Resistance

The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.

Also Known As:

Networked: 4037 relevant articles (150 outcomes, 403 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Disease Susceptibility (Diathesis)
3.	Triploidy
4.	Mycoses (Diseases, Fungus)
5.	Body Weight (Weight, Body)

Experts

1.	Dangl, Jeffery L: 28 articles (01/2019 - 02/2002)
2.	Song, Fengming: 25 articles (01/2022 - 10/2002)
3.	Harikrishnan, Ramasamy: 23 articles (12/2021 - 09/2009)
4.	Balasundaram, Chellam: 22 articles (12/2021 - 09/2009)
5.	Jones, Jonathan D G: 21 articles (01/2021 - 01/2002)
6.	Li, Dayong: 19 articles (01/2022 - 11/2008)
7.	Zhang, Huijuan: 19 articles (01/2017 - 09/2008)
8.	Shirasu, Ken: 19 articles (11/2016 - 08/2002)
9.	Tang, Dingzhong: 18 articles (06/2022 - 12/2002)
10.	Shi, Haitao: 18 articles (05/2022 - 08/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Disease Resistance:

1.	Proteins (Proteins, Gene)FDA Link 01/01/2018 - "MALDI-TOF analysis helped to detect four significant proteins that were linked to quality and disease resistance. " 08/18/2017 - "The importance of poultry as a global source of protein underpins the chicken genome and associated SNP data as key tools in selecting and breeding healthy robust birds with improved disease resistance. " 03/01/2011 - "A detailed analysis of the function-related proteins profiles helped discover a set of proteins of known Vitis gene origin as the potential candidates to play key roles in grapevine berry quality, growth regulation and disease resistance." 03/16/2013 - "This study provides a broad picture of differential accumulation of proteins and metabolites in postharvest citrus fruit, and gives new insights into HT improved fruit disease resistance during subsequent storage of 'Kamei' Satsuma mandarin. " 11/01/2023 - "CPK1-mediated ERF72 protein phosphorylation confers improved disease resistance to cassava bacterial blight."
2.	AntioxidantsIBA 12/29/2022 - "In conclusion, dietary SFE supplementation improved the growth performance, antioxidant activity and disease resistance of turbot, and SFE could be a potential feed additive for turbot." 11/24/2023 - "The present study was focused on the efficacy of Aloe barbadensis replacing fishmeal diets on hematological, serum biochemical, antioxidant, histopathological parameters, and disease resistance against A. " 12/29/2022 - "Dietary Supplementation of Sophora flavescens Root Extract Improved the Growth Performance, Antioxidant Capacity, Innate Immunity, and Disease Resistance against Edwardsiella tarda Challenge in Turbot (Scophthalmus maximus)." 09/13/2022 - "Dietary Supplementation with Eucommia ulmoides Leaf Extract Improved the Intestinal Antioxidant Capacity, Immune Response, and Disease Resistance against Streptococcus agalactiae in Genetically Improved Farmed Tilapia (GIFT; Oreochromis niloticus)." 09/01/2023 - "This study aimed at assessing 3 host gut-derived Bacillus species' effects on the growth, immune and antioxidant-biochemical responses, haematological parameters, intestinal morphology, immune-related gene expression, gut microbiota, and disease resistance against Vibrio harveyi in hybrid grouper. "
3.	EnzymesIBA 11/01/2019 - "One RSE eliminated almost the complete short arm of chromosome 1B, which contains major genes for flour quality, disease resistance and different enzymes. " 08/10/2023 - "Results showed that SUMs improved rice yield by increasing the number of effective panicles and filled grains, while also inhibiting soil acidification and enhancing disease resistance by improving soil enzyme activities. " 07/01/2020 - "Probiotics revealed greatest effect on the shrimp digestive system particularly in the larval and early post-larval stages, and stimulate the production of endogenous enzymes in shrimp and contribute with improved the enzyme activities in the gut, as well as disease resistance." 06/01/2022 - "A 95-day feeding trial was conducted to evaluate the outcomes of feeding Bacillus subtilis fermented Azolla (BSFA) on nonspecific immunity, antioxidative status, intestinal digestive enzymes and histomorphometry, and disease resistance in the Nile tilapia. " 11/01/2019 - "Aims of this study were to understand the role of metabolites and phenylpropanoid related enzymes in Alternaria leaf blight resistance and to find out metabolic marker for disease resistance. "
4.	HerbicidesIBA 01/01/2022 - "This review includes: an overview of the different breeding approaches for crop improvement; genome editing tools and their mechanism of action and application of the most widely used genome editing technology, CRISPR/Cas9, for crop improvement especially for agronomic traits such as disease resistance, abiotic stress tolerance, herbicide tolerance, yield and quality improvement, reduction of anti-nutrients, and improved shelf life; and an update on the regulatory approval of the genome-edited crops. " 01/01/2021 - "To date, genetically modified varieties represent 30% of the world's maize cultivated area and incorporate traits such as herbicide, insect and disease resistance, abiotic stress tolerance, high yield, and improved nutritional quality. " 02/01/2023 - "While conventional breeding is practiced for soybean improvement, with the advent of new biotechnological methods scientists have also engineered soybean to improve different traits (herbicide, insect, and disease resistance) to fulfill consumer requirements and to meet the global food deficiency. " 01/01/2019 - "Although transgenic cotton plants with disease resistance, abiotic stress tolerance, and improved fiber quality have been developed in the past decades, insect-resistant and herbicide-tolerant cottons are the two dominant cottons in transgenic cotton market." 01/01/2013 - "Although transgenic cotton plants with disease-resistance, abiotic stress tolerance, and improved fiber quality have been developed in the past decades, insect-resistant and herbicide-tolerant cotton are the two dominant transgenic cottons in the transgenic cotton market."
5.	NucleotidesIBA 07/01/2022 - "In summary, dietary 0.4-0.8 g kg-1 nucleotides promoted growth performance, enhanced immunity and improved intestinal morphology and disease resistance of largemouth bass." 07/01/2022 - "An 8 week feeding trial was carried out to investigate the effects of dietary nucleotides on growth performance, intestinal morphology, immune response and disease resistance of juvenile largemouth bass, Micropterus salmoides. " 03/01/2019 - "In this study, we firstly tested the effects of dietary nucleotides on the disease resistance and innate immunity of zebrafish. " 11/01/2018 - "In this study, a systematic analysis of Nucleotide-Binding Site (NBS) disease resistance (R) gene family in the barley, Hordeum vulgare L. " 11/01/2015 - "A 9-week feeding trial was conducted to investigate the effects of dietary nucleotides (NT) on growth, immune response and disease resistance of sea cucumber Apostichopus japonicas (initial weight: 5.87 ± 0.03 g). "
6.	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 09/18/2023 - "This study elucidated the involvement of salicylic acid (SA) in conferring broad-spectrum disease resistance in peanuts through the experimental approach of inoculating SA-treated leaves. " 06/01/2016 - "Several studies have shown that salicylic acid (SA) is a key endogenous component of local and systemic disease resistance in plants. " 05/01/2012 - "Further studies revealed that AtSR1/CAMTA3 is a negative regulator of plant defense, and Ca(2+)/CaM-binding to AtSR1 is indispensable for the suppression of salicylic acid (SA) accumulation and disease resistance. " 05/01/1997 - "Numerous studies argue that salicylic acid (SA) is an important component of the plant signal transduction pathway(s) leading to disease resistance. " 10/19/2023 - "Effect of Salicylic Acid Treatment on Disease Resistance to Coleosporium zanthoxyli in Chinese pepper (Zanthoxylum armatum)."
7.	Reactive Oxygen Species (Oxygen Radicals)IBA 01/01/2021 - "The disease resistance of RG watermelon seedlings may also be related to the improved scavenging capacity of reactive oxygen species (ROS). " 01/01/2022 - "The present study is a comparative study between Reactive Oxygen Species (ROS) signaling and antioxidative enzymatic signaling and deals with induced systemic resistance (ISR) in enhancing the disease resistance in typical tomato plant (Solanum lycopersicum L.) infected by the collar rot fungus, Sclerotium rolfsii (Teleomorph: Athelia rolfsii) by priming with Bacillus subtilis, Pseudomonas fluorescens, and their microbial consortia by a single strain of Bacillus subtilis, and P. " 08/01/1999 - "The combination of mutational and molecular studies has shed light on the role of reactive oxygen intermediates and programmed cell death in cereal disease resistance mechanisms. " 04/01/2022 - "Our results indicate that EPF induce systemic plant immunity and disease resistance by activating the plant host defense machinery, as evidenced by increases in reactive oxygen species production and defense gene expression, and that EPF promote plant growth. " 02/01/2022 - "dothidea, reflected by more severe symptoms and higher reactive oxygen species (ROS) content in the defective pear seedlings after inoculation, revealing that PbrPUB29 has a significant role in pear disease resistance. "
8.	VaccinesIBA 04/01/2020 - "casei vaccine were effective in improving crucian carp growth, immunity response and disease resistance. " 08/01/2018 - "As the A2906G polymorphism in NLRP3 is widely distributed in commercial pig breeds, Landrace, Large White and Berkshire pigs, there is potential for improvement in vaccine efficiency and disease resistance using this polymorphism in various pig populations." 01/01/2022 - "The discovery of the ASFV receptor provides novel ideas to study ASFV and host cell interactions, pathogenic mechanisms, development of receptor blockers, vaccine design, and disease resistance breeding." 01/01/2018 - "Thus, studies on the design and production of highly protective vaccines against this pathogen, as well as the mechanisms of vaccine-induced disease resistance are urgently needed. " 07/15/2012 - "Functional studies suggest that some alleles may have a disproportionally high impact on T cell responses, thus it may be important to consider their role in both disease resistance and vaccine efficacy. "
9.	jasmonic acid (jasmonate)IBA 12/01/2018 - "Plants grown in conditioned soil showed increased levels of jasmonic acid and improved disease resistance. " 01/01/2023 - "GIGANTEA supresses wilt disease resistance by down-regulating the jasmonate signaling in Arabidopsis thaliana." 06/01/2022 - "Jasmonic acid (JA) metabolism and disease resistance-related genes were induced in the transgenic tobacco, and the JA content significantly increased compared with in the wild type. " 01/01/2022 - "We found upregulation of several genes involved in ABA and jasmonic acid (JA) signaling, stomata regulation, osmotic potential maintenance, stress protection, and disease resistance in AtNOG1-1 and AtNOG1-2 overexpressor lines compared to the control. " 09/15/2021 - "The Jasmonic Acid Signaling Pathway is Associated with Terpinen-4-ol-Induced Disease Resistance against Botrytis cinerea in Strawberry Fruit."
10.	ResveratrolIBA 01/01/2017 - "These findings suggest that Chinese wild V. quinquangularis accession Danfeng-2 is an extremely important genetic resource for grape breeding and especially for increasing the resveratrol content of European grape cultivars for disease resistance and for improved human nutritional benefits." 01/01/2018 - "A number of studies have shown that the disease resistance of crops treated with resveratrol is markedly improved. " 07/01/2021 - "However, the molecular mechanism of resveratrol accumulation in the enhancement of disease resistance is unclear. " 01/01/2021 - "In particular, the resveratrol synthesis genes related to stress and disease resistance appeared induced in roots under the SS sowing treatment. " 01/01/2020 - "Resveratrol is notable not only for its functions in disease resistance in plants but also for its health benefits when it forms part of the human diet. "

Therapies and Procedures

1.	Therapeutics 01/01/2021 - "Disease resistance or relapse after successful initial therapy and declining efficacy of subsequent rounds of treatment were the basis for the development of alternative anti-CD20-based antibody therapies. " 11/01/2021 - "Endocrine therapy is the mainstay of treatment, however, due to the heterogeneous nature of the disease, resistance to endocrine therapy is not uncommon. " 01/01/2004 - "This may interfere with intrinsic disease resistance and with the efficacy of IFN therapy. " 07/12/2023 - "Mutated SF3B1 and TP53 are both associated with more aggressive disease, resistance to therapies and poorer overall survival for CLL. " 06/14/2023 - "Since most therapies fail to prevent rapid clonal evolution and disease resistance, new and non-invasive predictive markers are needed to monitor patients and adapt the therapeutic strategy. "
2.	Oral Administration 10/01/2021 - "This study aims to assess and determine the oral-administration of probiotic, Lactobacillus pentosus BD6 on growth performance, immunity and disease resistance of white shrimp, Litopenaeus vannamei. " 01/01/2023 - "In conclusion, the oral administration of EESC was found to be an effective functional feed additive to improve the growth, immune parameters, and disease resistance against V. parahaemolyticus in L.vannamei." 01/01/2021 - "In summary, oral administration of LGG to chickens could improve growth performance, maintain intestinal homeostasis, and enhance innate immune response and disease resistance." 05/01/2018 - "Next, we tested whether oral administration of rElSAA may enhance disease resistance. " 10/01/2015 - "The effects of oral administration of Bacillus licheniformis on growth performance, immunity, intestinal morphology and disease resistance of juvenile tilapia were investigated. "
3.	Immunomodulation 01/01/2019 - "In view of this trend, the probiotic properties of a potent antagonistic bacterium, Pseudomonas aeruginosa FARP72, was characterized in terms of safety, antagonistic activities, in vitro immunomodulation, and in vivo disease resistance. " 05/01/2018 - "However, the effects of dietary rElSAA supplementation on growth performance, immunomodulation and disease resistance in giant grouper have not been previously evaluated. " 05/01/2016 - "casseliflavus as a potential probiotics for rainbow trout with the capability of improving growth performance and enhancing disease resistance by immunomodulation." 05/01/2011 - "Enhancing the immune response using alternative approaches such as selection for increased disease resistance or dietary immunomodulation may be effective additions to the portfolio of strategies the industry applies in poultry health management. " 10/01/1992 - "pneumoniae by vaccination and transfer of immunocompetent cells to mice immunosuppressed by retroviral infection show the potential to use immunomodulation to affect disease resistance in AIDS."
4.	Plant-Based Diet 05/01/2006 - "Whilst advances in agronomic characteristics (improved yield and better pest and disease resistance) continue to be a very high priority, there is increasing opportunity to enhance the nutritional value of plant based diets by improving the nutritional quality of staple foods. " 05/01/2022 - "Furthermore, our results on trout strains with distinct selection backgrounds yields comparative insights into the adaptive gains brought about by selection programs for pathogen-specific disease resistance, as well as the non-specific immune enhancement associated with selection for utilization of plant-based diets."
5.	Immunotherapy 12/09/2022 - "Due to increasing disease resistance and treatment-related toxicity with age, further improvements are now expected from the expanding knowledge of ALL biology, more accurate risk stratification, and the early introduction of targeted small molecules and immunotherapy. " 11/01/2022 - "The group of patients who fail upfront therapy, between 25% and 40%, is enriched in high-risk characteristics (unfavorable genetics, persistent minimal residual disease) and represents the ideal setting for the study of molecular mechanisms of disease resistance, and consequently explore novel ways of restoration of drug sensitivity and assess patient/subset-specific patterns of drug vulnerability to targeting agents, immunotherapy and cell therapy. " 01/01/2021 - "Based upon PubMed and abstract searches primarily from the past 4 years, here we review the data supporting novel immunotherapies for R/R MM. Overcoming disease resistance remains a challenge in R/R MM. Novel therapeutic approaches targeting MM antigens and/or enhancing immune cell function offer the potential to prolong survival and are actively being investigated in clinical trials." 02/01/2020 - "This study will provide new insights into understanding the enhancing mechanism of BFT on immunity and disease resistance of cultured animals, and developing prebiotics/probiotics-based immunotherapies to improve animal health and disease resistance."