Autocrine Motility Factor Receptors

Cell surface receptors for AUTOCRINE MOTILITY FACTOR, which is the secreted form of GLUCOSE-6-PHOSPHATE ISOMERASE. The receptor has an unusual composition in that it shares some structural similarities with G-PROTEIN-COUPLED RECEPTORS and functions as an ubiquitin protein ligase when internalized.

Also Known As:

Networked: 73 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Raz, Avraham: 5 articles (10/2020 - 09/2002)
2.	Raz, A: 4 articles (08/2005 - 11/2001)
3.	Nabi, Ivan R: 3 articles (06/2019 - 12/2011)
4.	Haga, Arayo: 3 articles (02/2005 - 09/2002)
5.	Oda, M: 3 articles (03/2001 - 08/2000)
6.	Ohta, Y: 3 articles (03/2001 - 08/2000)
7.	Qian, Feng: 2 articles (01/2022 - 01/2022)
8.	Sun, Lei: 2 articles (01/2022 - 01/2022)
9.	Zhang, Huihui: 2 articles (01/2022 - 01/2022)
10.	Gorski, Sharon M: 2 articles (01/2021 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2017 - "The extent to which the AMF receptor was expressed on cancer cells did not correlate clearly with the cell motility stimulated by rhAMF. " 09/01/2015 - "The aberrant activation of autocrine motility factor receptor (AMFR) has been implicated in several types of human cancer. " 06/01/2003 - "The tumors of the lung, stomach and tumor cells in the sputum showed the same immunoreactivities of autocrine motility factor receptor (AMFR). " 03/01/2001 - "Expression of autocrine motility factor receptor (AMFR) associates with increased cell migration and poor survival in certain types of human cancers. " 03/01/2001 - "In the first model, despite no significant difference in the mean volume of the subpleural tumors between the groups, the degree of dissemination was suppressed in the treatment group with less tumor vasculature and with reduced expression of autocrine motility factor receptor (AMFR) in tumor cells. "
2.	Carcinoma (Carcinomatosis) 01/01/2023 - "The aim of this study was to evaluate the clinicopathological significance of autocrine motility factor receptor (AMFR) expression in a variety of human invasive micropapillary carcinomas (IMPC). " 01/01/2023 - "Expression of autocrine motility factor receptor (AMFR) in human breast and lung invasive micropapillary carcinomas." 11/01/1993 - "Autocrine motility factor-receptor in human bladder-carcinoma - gene-expression, loss of cell-contact regulation and chromosomal mapping." 01/01/2014 - "Aberrant expression of the autocrine motility factor receptor correlates with poor prognosis and promotes metastasis in gastric carcinoma." 06/15/1994 - "Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas."
3.	Melanoma (Melanoma, Malignant) 01/01/2002 - "Expression and function of the AMF receptor by human melanoma in experimental and clinical systems." 12/02/1993 - "These results suggest the existence of an "autocrine motility cycle" which influences melanoma cell motility by gp78 activation, and production of second messengers which affect the cytoskeletal architecture and expression of the AMF receptor itself." 01/15/1990 - "Based on such functional properties, it was concluded that gp78 behaves as an AMF receptor of the B16-F1 melanoma cell." 01/01/2002 - "Similar to previous studies on murine melanoma, activation of the AMF receptor upregulated beta3 while it downregulated beta1 integrins at the cell surface, inducing an integrin phenotype characteristic for invasive/metastatic melanoma. " 01/01/2002 - "The gp78/AMF receptor protein expression in human melanoma cell lines correlated to their in vivo spontaneous metastatic potential. "
4.	Choriocarcinoma 08/01/1996 - "Expression and function of autocrine motility factor receptor in human choriocarcinoma." 08/01/1996 - "Our purpose was to determine whether human choriocarcinoma cells express autocrine motility factor receptor (AMF-R) and to study its function in this tumor system. "
5.	Neoplasm Metastasis (Metastasis) 05/01/2015 - "Autocrine motility factor receptor (AMFR) has been linked to metastasis and tumorigenicity. " 03/30/1998 - "Since activation of the autocrine motility factor receptor stimulates invasion of a reconstituted basement membrane and enhances experimental metastasis by high- but not low-metastatic K1735 cells, differences in the invasive phenotypes of these cells may be due in part to their differential responses to external stimuli coupled with internal propensities toward either matrix degradation and migration (high-metastatic cells) or matrix remodeling and stasis (low-metastatic cells)." 02/01/1993 - "[The role of autocrine motility factor receptor in metastasis]." 01/01/2014 - "Aberrant expression of the autocrine motility factor receptor correlates with poor prognosis and promotes metastasis in gastric carcinoma." 11/20/2001 - "Autocrine motility factor receptor (AMF-R) has been shown to play an important role in tumor cell migration, invasion and metastasis. "

Related Drugs and Biologics

1.	Integrins
2.	Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)
3.	Proteins (Proteins, Gene)
4.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
5.	Membrane Glycoproteins (Membrane Glycoprotein)
6.	Cadherins (E-Cadherin)
7.	Cytokines
8.	platelet protein P47 (pleckstrin)
9.	Ubiquitin
10.	Sirolimus (Rapamycin)

Related Therapies and Procedures

1.	Therapeutics