Non-Infective Endocarditis

Formation of a non-infectious THROMBUS, referred to as vegetation, on previously undamaged ENDOCARDIUM. It usually occurs as a complication of connective-tissue diseases and cancers because of the associated hypercoagulable state (see THROMBOPHILIA).

Also Known As:

Endocarditis, Non-Infective; Endocarditis, Non-Bacterial Thrombotic; Marantic Endocarditis; Endocarditides, Marantic; Endocarditides, Non-Infective; Endocarditis, Marantic; Endocarditis, Non Infective; Marantic Endocarditides; Non Infective Endocarditis; Non-Infective Endocarditides; Non-Bacterial Thrombotic Endocarditis

Networked: 56 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 91362
- Heart Diseases: 26014
  - Endocarditis: 10233
    - Non-Infective Endocarditis: 56

Related Diseases

1.	Neoplasms (Cancer)
2.	Aortic Valve Insufficiency (Aortic Regurgitation)
3.	Endocarditis
4.	Disseminated Intravascular Coagulation
5.	Non-Infective Endocarditis

Experts

1.	Lepour, Maxence: 1 article (03/2022)
2.	Vereeke, Justine: 1 article (03/2022)
3.	Wauters, Aurélien: 1 article (03/2022)
4.	Wieërs, Grégoire J F G: 1 article (03/2022)
5.	Kawano, Hiroaki: 1 article (01/2022)
6.	Maemura, Koji: 1 article (01/2022)
7.	Minami, Takako: 1 article (01/2022)
8.	Omari, Abdullah: 1 article (01/2022)
9.	Phan, Justin: 1 article (01/2022)
10.	Schuetz, Priyanka: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Non-Infective Endocarditis:

1.	Heparin (Liquaemin)FDA LinkGeneric 01/01/2023 - "Non-bacterial thrombotic endocarditis: a highly dynamic entity with rapid response to initiation and discontinuation of heparin." 01/01/1982 - "Five patients had features post mortem of non-bacterial thrombotic endocarditis, and in one, the diagnosis had been made antemortem, but treatment with heparin did not prevent further emboli. " 03/16/2022 - "Reversibility of valve regurgitation due to cancer-related non-bacterial thrombotic endocarditis after switching direct oral anticoagulation for heparin." 08/01/2011 - "[Ischemic strokes as a presenting feature of marantic endocarditis despite heparin treatment]." 01/01/2022 - "Heparin treatment ameliorates aortic regurgitation due to malignancy-associated non-bacterial thrombotic endocarditis."
2.	FibrinIBA 01/01/2021 - "It is proposed that paraneoplastic non-bacterial thrombotic endocarditis (NBTE) is the most common cause, predisposing to the formation of friable valvular lesions composed of platelets and fibrin that embolize commonly. " 12/01/2016 - "Non-bacterial thrombotic endocarditis (NBTE) is an uncommon pathological situation, which involves the presence of bland, fibrin-platelet thrombi. " 10/04/2016 - "Histopathological examination of the remaining two cusps revealed sterile fibrin-rich thrombotic vegetations characteristic of non-bacterial thrombotic endocarditis." 03/01/2016 - "Non-bacterial thrombotic endocarditis (NBTE) is characterized by presence of sterile vegetations that develop from fibrin and platelets on heart valves. " 01/01/2016 - "Marantic endocarditis is characterized by the deposition of fibrin and thrombi on heart valves in the absence of microorganisms.Is"
3.	Dacarbazine (DIC)FDA LinkGeneric 03/13/2008 - "It represents a clinical continuum from a subclinical prothrombotic state to disseminated intravascular coagulation (DIC), venous thromboembolism (VTE) and non-bacterial thrombotic endocarditis (NBTE). " 01/01/2019 - "Ischemic stroke also may be a complication of metastatic disease with local invasion of vessels, a pro-thrombotic disorder such as non-bacterial thrombotic endocarditis (NBTE) or disseminated intravascular coagulation (DIC), or secondary to chemotherapy. " 09/01/2002 - "We describe a woman with recurrent stroke, disseminated intravascular coagulation (DIC) and non-bacterial thrombotic endocarditis (NBTE) caused by ovarian cancer (Trousseau syndrome). " 01/01/1991 - "The incidences of Af, DIC, mural thrombus, non-bacterial thrombotic endocarditis (NBTE) were significantly higher in the group with cerebral embolism than in the group with cerebral thrombosis. " 01/01/2014 - "A 63-year-old woman was diagnosed with advanced lung adenocarcinoma complicated by Trousseau's syndrome characterized by non-bacterial thrombotic endocarditis, asymptomatic brain infarction, deep venous thrombosis, and low-grade disseminated intravascular coagulation (DIC). "
4.	AnticoagulantsIBA 05/01/2021 - "Direct oral anticoagulants fail to prevent ischemic stroke associated with marantic endocarditis.>." 01/01/2017 - "A first described case of cancer-associated non-bacterial thrombotic endocarditis in the era of direct oral anticoagulants." 05/01/2021 - "This case illustrates the association between ATE and VTE in a patient with marantic endocarditis related to lung cancer and recurrence of ischemic stroke on direct oral anticoagulant therapy. " 05/01/2021 - "Recurrence of ischemic stroke on direct oral anticoagulant therapy in a patient with marantic endocarditis related to lung cancer."
5.	Anti-Bacterial Agents (Antibiotics)IBA 12/10/2022 - "The most common reasons for negative blood cultures were antibiotic treatment prior to blood culture sampling (35%), fastidious and slow growing microorganisms (30%) and definite non-infective endocarditis (8%). " 03/01/2006 - "Lack of response to empiric antibiotic treatment and further diagnostic work-up established the correct diagnosis of marantic endocarditis due to temporal arteritis. "
6.	Factor Xa InhibitorsIBA 01/01/2022 - "Splinters in the fingernails, heart and brain: thromboembolic complications of non-bacterial thrombotic endocarditis despite treatment with a direct-acting oral anticoagulant."
7.	Polyethylene (Polythene)IBA 12/01/2005 - "Non-bacterial thrombotic endocarditis of the aortic valve was induced by the insertion of a polyethylene catheter. "
8.	Anticardiolipin AntibodiesIBA 03/01/2009 - "Repeated negative blood cultures along with persistently elevated anticardiolipin antibody titers suggested a diagnosis of non-bacterial thrombotic endocarditis secondary to antiphospholipid syndrome. "
9.	Antiphospholipid AntibodiesIBA 01/01/2020 - "Differentiating non-bacterial thrombotic endocarditis (NBTE) from infective endocarditis can be a diagnostic challenge due to slow growing organisms; laboratory findings that suggest NBTE include the lack of leucocytosis, normal C-reactive protein, negative blood culture sets, and positive antiphospholipid antibodies.Serial"
10.	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 03/01/2016 - "[Non-bacterial thrombotic endocarditis on the bicuspid aortic valve in a 25-year-old male with lupus anticoagulant]."

Therapies and Procedures

1.	Catheters 12/01/1984 - "In a previous study we showed that the lesions of non-bacterial thrombotic endocarditis induced by means of implantation of a catheter in the left ventricle (LV) of the rabbit, undergo inner connectivization and surface endothelialization, which are completed within 2-3 months. " 10/01/1988 - "Endocardial damage by the catheter may result in non-bacterial thrombotic endocarditis. " 06/01/1980 - "On postmortem examination of 8 patients, in whom flow-directed balloon-tipped catheters were employed, and whose catheters were dissected in situ, there were 5 instances of non-bacterial thrombotic endocarditis (NBTE) and 4 of focal valvular bleeding. " 12/01/2005 - "Non-bacterial thrombotic endocarditis of the aortic valve was induced by the insertion of a polyethylene catheter. "
2.	Therapeutics 05/01/2021 - "This case illustrates the association between ATE and VTE in a patient with marantic endocarditis related to lung cancer and recurrence of ischemic stroke on direct oral anticoagulant therapy. " 05/01/2021 - "Recurrence of ischemic stroke on direct oral anticoagulant therapy in a patient with marantic endocarditis related to lung cancer." 09/01/2002 - "The patient also had aortic regurgitation due to non-infective endocarditis and systemic hypertension, and had been maintained on steroid therapy for 15 years. "
3.	Drug Therapy (Chemotherapy) 01/01/2007 - "Clinical manifestations vary from venous thromboembolism (VTE) to disseminated intravascular coagulation, more commonly observed in patients with haematological malignancies and those with widespread metastatic cancer, to arterial embolism, more commonly observed in patients undergoing chemotherapy and in those with non-bacterial thrombotic endocarditis." 01/01/2019 - "Ischemic stroke also may be a complication of metastatic disease with local invasion of vessels, a pro-thrombotic disorder such as non-bacterial thrombotic endocarditis (NBTE) or disseminated intravascular coagulation (DIC), or secondary to chemotherapy. "
4.	Thrombectomy 06/21/2021 - "Non-bacterial thrombotic endocarditis and coronary thrombectomy in a patient with metastatic small cell lung carcinoma."
5.	Radiotherapy 02/16/2004 - "Secondarily, non bacterial thrombotic endocarditis, septic or neoplastic cell embolism, venous sinus thrombosis and atherosclerosis secondary to radiotherapy have been reported. "