Expression of interleukin-6 in cerebral neurons and ovarian cancer tissue in Trousseau syndrome.

Abstract

Interleukin-6 (IL-6) is reportedly increased in serum and CSF from acute stroke patients. However, the cellular origin and possible role of IL-6 in CNS after stroke are unclear. We describe a woman with recurrent stroke, disseminated intravascular coagulation (DIC) and non-bacterial thrombotic endocarditis (NBTE) caused by ovarian cancer (Trousseau syndrome). The patient died 50 days after the final episode of cerebral embolism. The immunohistochemical study revealed IL-6 protein to have been expressed both in cerebral neurons spared from ischemic insult and in epithelial cells of the ovarian tumor. We speculate that IL-6 produced in ovarian cancer may be associated with the hypercoagulable state and the development of NBTE in this patient. In contrast, IL-6 induction in cerebral neurons may contribute to the survival of these neurons after a stroke.

• Authors: S Suzuki, K Tanaka, S Nogawa, A Umezawa, J Hata, Y Fukuuchi
• Journal: Clinical neuropathology (Clin Neuropathol) 2002 Sep-Oct Vol. 21 Issue 5 Pg. 232-5 ISSN: 0722-5091 [Print] Germany
• PMID: 12365726 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-6

Topics

• Coronary Thrombosis (etiology, pathology)
• Disseminated Intravascular Coagulation (etiology, pathology)
• Endocarditis (etiology, pathology)
• Female
• Humans
• Interleukin-6 (analysis)
• Middle Aged
• Neurons (pathology)
• Ovarian Neoplasms (complications, pathology)
• Recurrence
• Stroke (etiology, pathology)
• Syndrome