HLA-DRB5 Chains (HLA DRB5)

A subtype of HLA-DRB beta chains that is associated with the HLA-DR51 serological subtype.

Also Known As:

HLA DRB5; HLA-DRB5; HLA-DRB5 Antigen; Antigen, HLA-DRB5; HLA DRB5 Antigen; HLA DRB5 Chains

Networked: 51 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB5 Chains: 51
        HLA-DR51 antigen
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB5 Chains: 51
        HLA-DR51 antigen
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB5 Chains: 51
        HLA-DR51 antigen
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB5 Chains: 51
        HLA-DR51 antigen
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB5 Chains: 51
        HLA-DR51 antigen
  - Isoantigens: 1221
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB5 Chains: 51
        HLA-DR51 antigen
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB5 Chains: 51
        HLA-DR51 antigen

Experts

1.	Martin, Roland: 3 articles (09/2012 - 02/2004)
2.	Caillier, Stacy J: 2 articles (01/2019 - 10/2008)
3.	Oksenberg, Jorge R: 2 articles (01/2019 - 10/2008)
4.	Little, Julian: 2 articles (11/2018 - 07/2017)
5.	Andreassen, Ole A: 2 articles (01/2017 - 01/2016)
6.	Dale, Anders M: 2 articles (01/2017 - 01/2016)
7.	Desikan, Rahul S: 2 articles (01/2017 - 01/2016)
8.	Franke, Andre: 2 articles (01/2017 - 01/2016)
9.	Karlsen, Tom H: 2 articles (01/2017 - 01/2016)
10.	McEvoy, Linda K: 2 articles (01/2017 - 01/2016)

Related Diseases

1.	Rheumatoid Vasculitis 05/01/2012 - "Association of HLA-DRB5*01 with protection against cutaneous manifestations of rheumatoid vasculitis in Brazilian patients."
2.	Rheumatoid Arthritis 01/01/2017 - "Genome-wide conjunctional analysis identified 17 novel loci at false discovery rate less than 0.05 with overlap between PD and autoimmune diseases, including known PD loci adjacent to GAK, HLA-DRB5, LRRK2, and MAPT for rheumatoid arthritis, ulcerative colitis and Crohn disease. " 12/01/2023 - "Epigenome-wide methylation haplotype association analysis identified HLA-DRB1, HLA-DRB5 and HLA-DQB1 as risk factors for rheumatoid arthritis." 12/01/2017 - "This study aims to analyze human leukocyte antigen A (HLA-A), human leukocyte antigen B (HLA-B), human leukocyte antigen C (HLA-C), HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1* loci expression in patients with rheumatoid arthritis (RA) in the Federation of Bosnia and Herzegovina. "
3.	Inflammation (Inflammations) 10/01/2015 - "In the present study, we try to review the inflammation in AD and immunity-associated GWAS risk genes like HLA-DRB5/DRB1, INPP5D, MEF2C, CR1, CLU and TREM2. " 01/01/2023 - "Intestinal bacteria were also found to trigger intestinal inflammation and fibrosis, with HLA-DRB5 playing a central role in this process." 01/01/2023 - "Increased HLA-DRB5 expression driven by intestinal bacteria was found to promote IL-1α secretion, leading to intestinal inflammation and fibrosis, suggesting a possible target for the treatment of UC. "
4.	Demyelinating Diseases (Demyelinating Disease) 09/01/2008 - "In this study, we asked whether the MS-associated MHC class II molecules, HLA-DRB11501, HLA-DRB50101, and HLA-DRB1*0401, contribute to autoimmune CNS demyelination by promoting pathogenic T cell responses to human myelin basic protein (hMBP), using three transgenic (Tg) mouse lines expressing these MHC molecules. "
5.	Parkinson Disease 16 08/03/2011 - "The majority of studies have confirmed the association of the previously identified genetic risk factors, SNCA and MAPT, and two studies have identified three new PD susceptibility loci/genes (PARK16, BST1 and HLA-DRB5). "

Related Drugs and Biologics

1.	HLA-DRB1 Chains (HLA DRB1)
2.	HLA-DQB1 antigen (HLA DQB1)
3.	HLA-DRB3 Chains (HLA DRB3)
4.	Histocompatibility Antigens Class II
5.	HLA-C Antigens (HLA-C)
6.	Myelin Basic Protein
7.	HLA-DRB4 Chains (HLA DRB4)
8.	HLA-B Antigens (HLA-B)
9.	HLA-A Antigens (HLA-A)
10.	HLA Antigens (Human Leukocyte Antigens)

Related Therapies and Procedures

1.	Punctures
2.	Immunotherapy