HLA-DRB4 Chains (HLA DRB4)

A subtype of HLA-DRB beta chains that is associated with the HLA-DR53 serological subtype.

Also Known As:

HLA DRB4; HLA-DRB4; HLA-DRB4 Antigen; Antigen, HLA-DRB4; HLA DRB4 Antigen; HLA DRB4 Chains

Networked: 26 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB4 Chains: 26
        HLA-DR53: 35
        HLA-DRB4*01:03:01 antigen
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB4 Chains: 26
        HLA-DR53: 35
        HLA-DRB4*01:03:01 antigen
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB4 Chains: 26
        HLA-DR53: 35
        HLA-DRB4*01:03:01 antigen
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB4 Chains: 26
        HLA-DR53: 35
        HLA-DRB4*01:03:01 antigen
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB4 Chains: 26
        HLA-DR53: 35
        HLA-DRB4*01:03:01 antigen
  - Isoantigens: 1221
    - Histocompatibility Antigens: 1132
      - HLA Antigens: 8934
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB4 Chains: 26
        HLA-DR53: 35
        HLA-DRB4*01:03:01 antigen
      - Histocompatibility Antigens Class II: 2170
        HLA-D Antigens: 238
        HLA-DR Antigens: 5477
        HLA-DR beta-Chains: 64
        HLA-DRB4 Chains: 26
        HLA-DR53: 35
        HLA-DRB4*01:03:01 antigen

Experts

1.	Martorana, Davide: 2 articles (04/2015 - 09/2007)
2.	Vaglio, Augusto: 2 articles (04/2015 - 09/2007)
3.	Ghaffarnia, Roya: 1 article (01/2022)
4.	Saffarian, Zahra: 1 article (01/2022)
5.	Shahbazi, Majid: 1 article (01/2022)
6.	Zamani, Mahdi: 1 article (01/2022)
7.	Bae, Jung Yun: 1 article (11/2020)
8.	Choi, Kyung Un: 1 article (11/2020)
9.	Chung, So Hak: 1 article (11/2020)
10.	Kim, Ahrong: 1 article (11/2020)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/01/2002 - "Besides being a general marker for increased susceptibility to childhood ALL in males, HLA-DRB4 is over-represented in high-risk patients. " 07/01/2002 - "A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL." 07/01/2002 - "Previous studies reported significant HLA-DR associations with various leukemias one of which is with HLA-DRB4 (DR53) family in male patients with childhood ALL. " 07/15/1999 - "The cross-reactivity between HLA-DR53 and H-2Ek, extensive mimicry of the immunodominant epitope of HLA-DR53 by several carcinogenic viruses, and the extra amount of DNA in the vicinity of the HLA-DRB4 gene argue for the case that HLA-DRB4*01 may be one of the genetic risk factors for childhood ALL."
2.	Rheumatoid Arthritis 10/01/2016 - "Genomic stratification by expression of HLA-DRB4 alleles identifies differential innate and adaptive immune transcriptional patterns - A strategy to detect predictors of methotrexate response in early rheumatoid arthritis." 12/01/2017 - "This study aims to analyze human leukocyte antigen A (HLA-A), human leukocyte antigen B (HLA-B), human leukocyte antigen C (HLA-C), HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1* loci expression in patients with rheumatoid arthritis (RA) in the Federation of Bosnia and Herzegovina. "
3.	Vitiligo 01/01/2022 - "In this study, we have evaluated the association and role of HLA-DRB401:01, -DRB107:01, and -DQB1*03:03:2 genes in different clinical subtypes of Vitiligo in the Iranian population. "
4.	Leukemia 07/01/2002 - "Previous studies reported significant HLA-DR associations with various leukemias one of which is with HLA-DRB4 (DR53) family in male patients with childhood ALL. "
5.	Genetic Predisposition to Disease (Genetic Predisposition) 03/01/2000 - "The HLA-DRB4 gene does not explain genetic susceptibility in HLA-DQ2-negative celiac disease." 01/01/2018 - "ASIA is associated with an individual genetic predisposition that is probably associated with the carriage of HLA-DRB101 or HLA-DRB4. " 06/01/2017 - "The emergence of ASIA syndrome is associated with individual genetic predisposition, for instance those carrying HLA-DRB101 or HLA-DRB4 and results from exposure to external or endogenous factors triggering autoimmunity. "

Related Drugs and Biologics

1.	HLA-DRB1 Chains (HLA DRB1)
2.	HLA-DQB1 antigen (HLA DQB1)
3.	HLA-DRB3 Chains (HLA DRB3)
4.	HLA Antigens (Human Leukocyte Antigens)
5.	HLA-DRB5 Chains (HLA DRB5)
6.	HLA-C Antigens (HLA-C)
7.	HLA-B Antigens (HLA-B)
8.	HLA-A Antigens (HLA-A)
9.	HLA-DR Antigens (HLA-DR)
10.	HLA-DRB4 Chains (HLA DRB4)

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