Bacterial Secretion Systems

In GRAM NEGATIVE BACTERIA, multiprotein complexes that function to translocate pathogen protein effector molecules across the bacterial cell envelope, often directly into the host. These effectors are involved in producing surface structures for adhesion, bacterial motility, manipulation of host functions, modulation of host defense responses, and other functions involved in facilitating survival of the pathogen. Several of the systems have homologous components functioning similarly in GRAM POSITIVE BACTERIA.

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Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jiang, Chunyan: 2 articles (06/2022 - 01/2021)
2.	Liu, Xin: 2 articles (06/2022 - 01/2021)
3.	Tan, Yong: 2 articles (06/2022 - 01/2021)
4.	Wang, Xiaoxu: 2 articles (06/2022 - 01/2021)
5.	Xiao, Shiju: 2 articles (06/2022 - 01/2021)
6.	Zhang, Guangzhong: 2 articles (06/2022 - 01/2021)
7.	Felise, Heather B: 2 articles (01/2010 - 10/2008)
8.	Miller, Samuel I: 2 articles (01/2010 - 10/2008)
9.	Cheng, Yungchi: 1 article (06/2022)
10.	Wu, Lingjun: 1 article (06/2022)

Related Diseases

1.	Infections 12/04/2023 - "The genomic analysis with online tools unravelled the various genes belonging to the bacterial secretion system, antibiotic resistance, virulence, efflux pumps, etc. The isolate showed the motility behavior that contributes to Enterobacter persistence in a stressed environment and further supports infections. " 01/01/2023 - "However, bacterial secretion systems often introduce agonists of immune sensors into the host cytosol during infection. " 01/01/2023 - "These key microbes were proven to protect the cucumber from pathogen infection by inducing high ROS level in the roots through enrichment of pathways, including a two-component system, a bacterial secretion system, and flagellar assembly revealed by metagenomics sequencing. " 07/19/2022 - "Finally, the use of antimicrobial peptides (AMPs) as a cellular device for bacterial secretion systems will be discussed as emerging potential candidates for the treatment of multidrug resistance infections." 01/01/2022 - "pylori infection group was enriched in the pathways of metabolism and infectious diseases (energy metabolism, bacterial secretion system, glutathione metabolism, protein folding and associated processing, sulphur metabolism, membrane and intracellular structural molecules, lipopolysaccharide biosynthesis, ubiquinone and other terpenoid-quinone biosynthesis, inorganic ion transport and metabolism, and metabolism of cofactors and vitamins) when compared with the H. "
2.	Bacterial Infections (Bacterial Infection) 10/16/2008 - "This work provides a proof of concept that compounds with a broad spectrum of activity against Gram-negative bacterial secretion systems could be developed to prevent and treat bacterial diseases." 01/01/2023 - "During bacterial infection, effector proteins are delivered into host cells through dedicated bacterial secretion systems and can modulate important cellular pathways by covalently modifying their host targets. " 08/01/2009 - "A common feature of NLR proteins that trigger inflammasome assembly in response to bacterial infection is that they appear to sense membrane perturbation or delivery of bacterial components into the cytosol through bacterial pore-forming toxins or bacterial secretion systems. " 12/23/2021 - "glumae also causes bacterial disease in other crops because it has various virulence factors, such as toxins, proteases, lipases, extracellular polysaccharides, bacterial motility, and bacterial secretion systems. "
3.	Epstein-Barr Virus Infections 06/01/2022 - "Ten KEGG pathway were significantly enriched in GP: bacterial secretion system, ribosome, sphingolipid signaling pathway, steroid hormone biosynthesis, complement and coagulation cascades, proteoglycans in cancer, FOXO signaling pathway, cGMP-PKG signaling pathway, insulin resistance, and Epstein-Barr virus infection. "
4.	Porcine Reproductive and Respiratory Syndrome (PRRS) 10/01/2012 - "pneumophila exhibit mitogen-activated protein (MAP) kinase (MAPK) activation that is independent of known PRRs but dependent on a functional bacterial secretion system. "
5.	Gram-Negative Bacterial Infections 01/01/2010 - "In this review, the feasibility of gram-negative bacterial secretion systems for the development of anti-virulence agents and possible arenas for their utility in therapeutic intervention of gram-negative bacterial infections such as gastroenteritis, nosocomial infections, and venereal diseases are discussed."

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Proteins (Proteins, Gene)
3.	Phosphotransferases (Kinase)
4.	Inflammasomes
5.	Virulence Factors (Pathogenicity Factors)
6.	Mitogen-Activated Protein Kinase Kinases (MEKs)
7.	Glucuronic Acid (Glucuronate)
8.	Vitamins
9.	Ubiquinone
10.	Terpenes (Terpenoids)