Prospects for the development and use of gram-negative bacterial virulence protein secretion inhibitors for prophylaxis and treatment of infectious diseases.

Abstract

As the breadth and number of bacterial pathogens exhibiting antibiotic resistance is rapidly increasing, our ability to treat new and re-emerging infectious diseases is being threatened. Therefore, the development of new therapeutic strategies, including drugs acting on new targets, is required. In this review, the feasibility of gram-negative bacterial secretion systems for the development of anti-virulence agents and possible arenas for their utility in therapeutic intervention of gram-negative bacterial infections such as gastroenteritis, nosocomial infections, and venereal diseases are discussed.

• Authors: Heather B Felise, Samuel I Miller
• Journal: Critical reviews in immunology (Crit Rev Immunol) Vol. 30 Issue 1 Pg. 69-77 ( 2010) ISSN: 1040-8401 [Print] United States
• PMID: 20370621 (Publication Type: Journal Article, Review)

Chemical References

• Bacterial Proteins
• Virulence Factors

Topics

• Antibiotic Prophylaxis
• Bacterial Proteins (metabolism)
• Communicable Disease Control
• Communicable Diseases (therapy)
• Gram-Negative Bacteria (drug effects, pathogenicity)
• Humans
• Virulence Factors (antagonists & inhibitors, metabolism)