A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
Also Known As:
Signal Transducer and Activator of Transcription 3; APRF Transcription Factor; Acute-Phase Response Factor; IL6-Response Factor; LIF-Response Factor; STAT3 Protein; STAT3a Transcription Factor; STAT3b Transcription Factor; Stat3alpha Transcription Factor; Stat3beta Transcription Factor; Acute Phase Response Factor; IL6 Response Factor; LIF Response Factor; Response Factor, Acute-Phase; Transcription Factor, APRF; Transcription Factor, STAT3; Transcription Factor, STAT3a; Transcription Factor, STAT3b; Transcription Factor, Stat3alpha; Transcription Factor, Stat3beta