55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Also Known As:
CD4 Antigen; Receptors, CD4; Receptors, Surface CD4; Surface CD4 Receptor; Antigen, CD4; Antigens, T-Cell T4; CD4 Receptor, Surface; CD4 Receptors, Surface; Receptor, CD4; Surface CD4 Receptors; T-Cell T4 Antigens; T4 Antigens, T Cell; Antigens, CD4; CD4 Molecule; CD4 Receptor; CD4 Receptors; T4 Antigens, T-Cell