Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Also Known As:
4-Carboxyglutamic Protein, Bone; Bone gamma-Carboxyglutamic Acid Protein; 4 Carboxyglutamic Protein, Bone; Bone 4-Carboxyglutamic Protein; Bone gamma Carboxyglutamic Acid Protein; Calcium Binding Protein, Vitamin K Dependent; Protein, Bone 4-Carboxyglutamic; Protein, Bone Gla; Vitamin K Dependent Bone Protein; Bone Gla Protein; Calcium-Binding Protein, Vitamin K-Dependent; Gla Protein, Bone; Vitamin K-Dependent Bone Protein; Osteocalcin (human reduced), 3-de-L-tyrosine-4-de-L-glutamine-5-de-L-tryptophan-6-de-L-leucine-9-L-serine-12-L-serine-19-L-threonine-22-L-glutamine-28-L-alanine-33-L-serine-35-L-glutamine-36-L-tyrosine-38-L-leucine-39-L-lysine-40-L-threonine-43-L-lysine-45-L-isoleucine-48-L-isoleucine-49-L-threonine-49a-L-isoleucine-