Pneumococcal Pneumonia

10/01/2022 - "PCV was highly efficacious against vaccine-type pneumococcal pneumonia."
01/01/2017 - "Our meta-analysis revealed significant VE of PPV23 against both IPD and pneumococcal pneumonia by any serotype in the elderly, comparable to the efficacy of PCV13 against vaccine-serotype disease in a recent clinical trial in elderly people. "
10/26/2012 - "If, however, the vaccine does not offer protection against non-bacteraemic pneumococcal pneumonia or the vaccine was introduced concomitantly with the infant 13 valent pneumococcal conjugate vaccination programme then vaccinating high risk people would (more) likely be cost effective. "
03/22/2007 - "Intranasal immunisation with the SlrA-IgA1p or trivalent vaccine combinations without additional adjuvants showed significant protection against fatal pneumococcal pneumonia in mice. "
09/01/2002 - "In the 35-year-old patient where the incidence of pneumococcal pneumonia is higher (0.85/1000), the vaccine would be cost-effective with an efficacy as low as 30 percent. "

06/01/2004 - "Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: a study by the Asian Network for Surveillance of Resistant Pathogens."
10/05/2023 - "Assessing prescription of antibiotics after vaccination against pneumococcal pneumonia; using prescription sequence symmetry analysis."
01/01/2022 - "The outcome was symptoms consistent with community-acquired pneumococcal pneumonia (CAP) requiring antibiotics or hospitalisation. "
01/01/2020 - "Antibiotics are the primary line of treatment for pneumococcal pneumonia; however, rising antimicrobial resistance is becoming more prevalent. "
12/01/2019 - "Conclusion Antibiotic de-escalation based on the 2017 JRS guidelines leads to a reduction in total antibiotic costs for the management of community-acquired nonbacteremic pneumococcal pneumonia."

03/08/2010 - "To determine the efficacy of a 23-valent pneumococcal polysaccharide vaccine in people at high risk of pneumococcal pneumonia. "
01/01/2000 - "The efficacy of pneumococcal vaccines in protecting against pneumococcal pneumonia can feasibly be measured only with a diagnostic technique that has a high specificity (0.98 to 1.00) and a sensitivity greatly exceeding that of blood cultures (>0.2 to 0.3). "
01/01/2018 - "Because of a lack of gold standard diagnostics, a combination of multiple diagnostic tests, or composite diagnostic standard, has been used to measure pneumococcal pneumonia (PP) in pneumococcal vaccine trials. "
01/01/2023 - "Although randomized controlled trials have examined the effects of pneumococcal vaccines, few epidemiological studies have investigated the onset of pneumococcal pneumonia in general practice. "
01/01/2017 - "Serotype-specific effectiveness of 23-valent pneumococcal polysaccharide vaccine against pneumococcal pneumonia in adults aged 65 years or older: a multicentre, prospective, test-negative design study."

07/01/1979 - "Pneumococcal pneumonia in rats with intact host defense mechanisms could be successfully cured by penicillin. "
03/28/1998 - "Different clinical studies have demonstrated that mortality due to pneumococcal pneumonia has not been affected by the development of resistant strains, eventually because the strains involved belong to less invasive serotypes than penicillin susceptible pneumococci. "
01/01/1994 - "This study suggests that 80% of the community-acquired pneumococcal pneumonia in a population with a high prevalence rate of disease requiring hospital admission are very sensitive in vitro to penicillin in contrast with its seldom clinical use in the authors environment. "
04/01/1956 - "The relevance of these in vitro observations to the curative action of penicillin was demonstrated in a systematic histologic study of the antimicrobial effect of the drug in experimental (type I) pneumococcal pneumonia. "
02/01/1950 - "Immunological studies of pneumococcal pneumonia in patients treated with penicillin."

01/01/2022 - "Indirect benefits from childhood PCV vaccination and polysaccharide vaccination of older adults have not substantially decreased the burden of pneumococcal pneumonia in older adults."
10/15/2015 - "Differences in Homing Potentials of Streptococcus pneumoniae-Specific Plasmablasts in Pneumococcal Pneumonia and After Pneumococcal Polysaccharide and Pneumococcal Conjugate Vaccinations."
07/01/2000 - "Antibody to capsular polysaccharide of Streptococcus pneumoniae at the time of hospital admission for Pneumococcal pneumonia."
05/01/1991 - "To improve diagnostic options for pneumococcal pneumonia, an ELISA system was developed that can detect less than or equal to 6 ng/ml capsular polysaccharide in serum. "
05/01/1991 - "Detection of capsular polysaccharide in serum for the diagnosis of pneumococcal pneumonia: clinical and experimental evaluation."

11/06/2012 - "Effective protection against secondary pneumococcal pneumonia by oral vaccination with attenuated Salmonella delivering PspA antigen in mice."
01/01/2020 - "Although pneumococcal urinary antigen tests (PUATs) have universally been used for the diagnosis of pneumococcal pneumonia, data on the efficacy of these exams are limited. "
02/01/1993 - "Detection of pneumococcal antigen may help to increase the rate of diagnosis of pneumococcal pneumonia. "
07/01/2018 - "The aim of this study was to evaluate the usefulness of SofiaFIA® urinary antigen test (UAT) in comparison with classical immunochromatographic BinaxNOW® test for the diagnosis of pneumococcal pneumonia (PP). "
01/01/2012 - "The present study was conducted to characterize the clinical features of pneumococcal pneumonia after the introduction of the urinary antigen test. "

02/01/2005 - "The poor specificity of chest radiographs (CXRs) to diagnose pneumococcal pneumonia may underestimate the efficacy of pneumococcal conjugate vaccine in preventing pneumococcal pneumonia. "
01/01/2022 - "Long-term impact of pneumococcal conjugate vaccines for children on adult pneumococcal pneumonia in Japan: Two multicenter observational studies from 2011 to 2020."
11/06/2019 - "Introduction This study was conducted in two purposively selected slums of Dhaka to assess parents' awareness of pneumococcal conjugate vaccine (PCV) in reducing the occurrence of death due to pneumococcal pneumonia. "
01/01/2023 - "Pneumococcal pneumonia remains a WHO high-priority disease despite multivalent conjugate vaccines administered in clinical practice worldwide. "
01/01/2022 - "Pediatric pneumococcal conjugate vaccines (PCVs) introduction has directly and indirectly reduced pneumococcal pneumonia and invasive disease caused by PCV-covered serotypes among children and adults globally. "

08/02/2013 - "With regard to future vaccination strategies, simply increasing mucosal anti-pneumococcal protein Ig levels, without addressing functional protective response, is not likely to be effective in preventing pneumococcal pneumonia in HIV-infected individuals. "
01/01/2021 - "In human studies, RIPK3 protein concentrations were significantly elevated and were identified as a potential plasma marker of pneumococcal pneumonia. "
01/01/2022 - "PspA is a vital component of the pneumococcal virulence arsenal - therefore, understanding the molecular aspects of this protein is essential in understanding pneumococcal pathogenesis and utilizing PspA as a target for treating or preventing pneumococcal pneumonia."
12/01/2014 - "DNAX-activating protein of 12 kDa impairs host defense in pneumococcal pneumonia."
11/01/2014 - "Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia."

10/14/2023 - "Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function."
08/01/2004 - "There is a non-significant trend to higher mortality in patients with pneumococcal pneumonia caused by intermediately resistant strains; however, they do not have a poorer outcome when they are treated with amoxicillin."
10/25/2003 - "The third patient died, despite extensive treatment, of multiorgan failure and sloughing of 70% of the skin, probably as a reaction to amoxicillin given for pneumococcal pneumonia."
12/01/1999 - "In view of our results, the guidance to increase the amoxicillin-loading dose in pneumococcal pneumonia appears to be immediately clinically relevant."
03/01/2005 - "Pulmonary damage and bacterial load in assessment of the efficacy of simulated human treatment-like amoxicillin (2,000 milligrams) therapy of experimental pneumococcal pneumonia caused by strains for which amoxicillin MICs differ."

06/01/1992 - "Individual efficacy of clarithromycin (A-56268) and its major human metabolite 14-hydroxy clarithromycin (A-62671) in experimental pneumococcal pneumonia in the mouse."
06/01/1992 - "An experimental mouse model was used to compare the efficacy of clarithromycin versus 14-OH clarithromycin in pneumococcal pneumonia by treatment with either the parent drug or its 14-OH metabolite alone. "
04/15/2022 - "She was treated with MEPM for pneumococcal pneumonia, a standard regimen containing clarithromycin for pulmonary M. "
05/01/2002 - "Pharmacodynamic assessment of clarithromycin in a murine model of pneumococcal pneumonia."
01/01/2002 - "High efficacy of clarithromycin for the treatment of moderate and mild pneumonia (including pneumococcal pneumonia) was demonstrated. "

11/01/2018 - "In light of globally increasing life-expectancy, a better understanding of the patho-mechanisms of elderly pneumococcal pneumonia, including alterations in innate immune responses, is needed to develop improved therapies. "
02/24/2014 - "Combinatorial therapy resulted in comparable bactericidal activity against the multi-drug resistant isolate and may represent an alternative dosing strategy, which may help to alleviate problems with pneumococcal pneumonia."
03/01/2004 - "Survival in patients with bacteremic community-acquired pneumococcal pneumonia can be improved by avoiding suboptimal therapy. "
04/01/2009 - "The only recent study of patients with bacteremic pneumococcal pneumonia failed, however, to show benefit of combination therapy. "
10/01/2021 - "Host-informed therapies for the treatment of pneumococcal pneumonia."

01/01/2017 - "The study aimed to investigate whether the clinical presentations and outcomes (length of stay, ICU admission, and 30-day mortality) of pneumococcal pneumonia in virologically suppressed patients who were HIV-infected on ART with a CD4+ T-cell count > 350 cells/mm3 are comparable to those seen in patients with HIV, using a case-control design. "
10/11/2021 - "Length of stay for IPD and pneumococcal pneumonia episodes were insignificantly different in the two periods. "
01/01/2016 - "Incidence, length of stay, and case-fatality rates of hospitalized all-cause and pneumococcal pneumonia were determined for 2004-2010 using ICD-10 discharge data from the Canadian Institutes for Health Information Discharge Abstract Database. "
11/25/2015 - "Our findings suggest that in patients aged <65 years, age and serum ChE and T-cho levels were associated with both the severity of pneumococcal pneumonia and length of stay. "
07/01/2013 - "US hospital stays for SpHUS appear to be increasing along with those for complicated pneumococcal pneumonia."

01/01/1998 - "The current study was undertaken to determine the efficacy of partial liquid ventilation with a perfluorocarbon (FC-77) in the treatment of pneumococcal pneumonia in rats. "
02/01/2002 - "Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia."
01/01/1998 - "Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia."
01/01/1998 - "These observations suggest that partial liquid ventilation with perfluorocarbon in combination with antibiotic administration may be an effective therapeutic modality in pneumococcal pneumonia."

12/01/1996 - "The intensive care management, mortality and prognostic indicators in severe community-acquired pneumococcal pneumonia."
01/01/1989 - "A retrospective study analyzing the case notes of 49 hospitalized adults, either in intensive care (n = 26) or in thoracic medicine units (n = 23), for acute bacteriologically proven pneumococcal pneumonia based on samples obtained other than by sputum examination. "
03/02/2021 - "Nonetheless, mechanically ventilated intensive care patients, who have a high risk of contracting pneumonia, rarely develop pneumococcal pneumonia. "
06/13/1992 - "The prognosis of pneumococcal pneumonia with a fulminant course has not improved in the last few decades despite proper antibiotics and intensive care treatment. "
06/16/2014 - "In the previous issue of Critical Care, the infusion of exogenous adrenomedullin is suggested to protect against increased lung endothelial permeability and end-organ dysfunction in a model of pneumococcal pneumonia in mechanically ventilated mice, possibly by stabilizing vascular endothelia. "

01/01/2017 - "Injectable polyvalent pneumococcal vaccination provides significant protection against community-acquired pneumonia, although no evidence indicates that vaccination reduced the risk of confirmed pneumococcal pneumonia, which was a relatively rare event. "
01/01/1949 - "The treatment of pneumococcal pneumonia by penicillin in aqueous solution at long intervals; effectiveness of two doses in first 24 hours followed by single daily injections."
10/01/1998 - "Currently recommended initial treatment of pneumococcal pneumonia in otherwise healthy patients requiring hospitalization consists of cefuroxime, ceftriaxone, or cefotaxime; some authors continue to emphasize injectable penicillin. "