DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Also Known As:
Topoisomerase II; DNA Topoisomerase (ATP-Hydrolysing); DNA Topoisomerases, Type II; DNA Topoisomerase II alpha; DNA Topoisomerase II beta; DNA Type 2 Topoisomerase; TOP2A Protein; TOP2B Protein; Topoisomerase II alpha; Topoisomerase II beta; Type II DNA Topoisomerase; alpha, Topoisomerase II; beta, Topoisomerase II; DNA Topoisomerase II