Dientamoebiasis

Gastrointestinal infection with organisms of the genus DIENTAMOEBA.

Also Known As:

Dientamoeba Infection; Dientamoeba fragilis Infection; Dientamoeba Infections; Dientamoeba fragilis Infections; Dientamoebiases; Infection, Dientamoeba; Infection, Dientamoeba fragilis; Infections, Dientamoeba; Infections, Dientamoeba fragilis

Networked: 10 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Giardiasis
2.	Infections
3.	Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
4.	Cysts

Experts

1.	Ellis, John T: 2 articles (10/2013 - 12/2012)
2.	Stark, Damien: 2 articles (10/2013 - 12/2012)
3.	Girginkardeşler, N: 2 articles (06/2008 - 02/2003)
4.	Ok, U Z: 2 articles (06/2008 - 02/2003)
5.	Jokiranta, T Sakari: 1 article (07/2019)
6.	Kantele, Anu: 1 article (07/2019)
7.	Kerttula, Anne-Marie: 1 article (07/2019)
8.	Meri, Taru: 1 article (07/2019)
9.	Pakarinen, Laura: 1 article (07/2019)
10.	Pietilä, Jukka-Pekka: 1 article (07/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dientamoebiasis:

1.	Formaldehyde (Formol)FDA Link 07/01/2019 - "In addition, we evaluated an improved approach to formalin-fixed samples for suitability in Dientamoeba diagnostics.MethodsThis study comprised four parts: (i) a descriptive part scrutinising rates of Dientamoeba findings; (ii) a methodological part analysing an approach to detect Dientamoeba-like structures in formalin samples; (iii) a clinical part comparing demographics and symptoms between patients with dientamoebiasis (n = 352) and giardiasis (n = 272), and (iv) a therapeutic part (n = 89 patients) investigating correlation between faecal eradication and clinical improvement.ResultsThe rate of Dientamoeba findings increased 20-fold after introducing criteria for Dientamoeba-like structures in formalin-fixed samples (88.9% sensitivity and 83.3% specificity). " 07/01/2019 - "This results from underdiagnosis: microscopic screening methods either lack sensitivity (wet preparation) or fail to reveal Dientamoeba (formalin-fixed sample).AimIn a retrospective study setting, we characterised the clinical picture of dientamoebiasis and compared it with giardiasis. "
2.	Metronidazole (Metric)FDA LinkGeneric 06/01/2014 - "Metronidazole therapy for treating dientamoebiasis in children is not associated with better clinical outcomes: a randomized, double-blinded and placebo-controlled clinical trial." 06/01/2008 - "This study compared the efficacies of metronidazole and ornidazole in a group of 112 patients with dientamoebiasis. " 06/01/2008 - "A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis." 12/01/2012 - "Treatments reported to be successful for dientamoebiasis include carbarsone, diphetarsone, tetracyclines, paromomycin, erythromycin, hydroxyquinolines and the 5-nitroimidazoles, including metronidazole, secnidazole, tinidazole and ornidazole. "
3.	OrnidazoleIBA 06/01/2008 - "These results suggest that single-dose ornidazole may be an important alternative agent for the treatment of dientamoebiasis." 06/01/2008 - "This study compared the efficacies of metronidazole and ornidazole in a group of 112 patients with dientamoebiasis. " 06/01/2008 - "A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis." 12/01/2012 - "Treatments reported to be successful for dientamoebiasis include carbarsone, diphetarsone, tetracyclines, paromomycin, erythromycin, hydroxyquinolines and the 5-nitroimidazoles, including metronidazole, secnidazole, tinidazole and ornidazole. "
4.	Proteins (Proteins, Gene)FDA Link 01/01/2018 - "In this study for the first time, a Dientamoeba fragilis protein profile by MALDI-TOF MS was created in order to identify specific markers for the application of this technology in the laboratory diagnosis of dientamoebiasis. "
5.	Paromomycin (Paromomycin Sulfate)FDA LinkGeneric 01/01/2007 - "Treatment with paromomycin (25-35 mg/kg/d for 7 days) was evaluated prospectively in 15 children with Dientamoeba fragilis infection after 1-month follow-up. " 01/01/2007 - "Treatment of Dientamoeba fragilis infection with paromomycin." 12/01/2012 - "Treatments reported to be successful for dientamoebiasis include carbarsone, diphetarsone, tetracyclines, paromomycin, erythromycin, hydroxyquinolines and the 5-nitroimidazoles, including metronidazole, secnidazole, tinidazole and ornidazole. "
6.	secnidazoleIBA 02/01/2003 - "To our knowledge, this is the first report of secnidazole being used in the treatment of dientamoebiasis." 02/01/2003 - "To evaluate the pathogenicity of Dientamoeba fragilis by comparing it with Giardia lamblia and to investigate the effect of a single dose of secnidazole in dientamoebiasis. " 12/01/2012 - "Treatments reported to be successful for dientamoebiasis include carbarsone, diphetarsone, tetracyclines, paromomycin, erythromycin, hydroxyquinolines and the 5-nitroimidazoles, including metronidazole, secnidazole, tinidazole and ornidazole. "
7.	Leukocyte L1 Antigen Complex (Calgranulin)IBA 10/01/2013 - "Our demonstration of long-term parasite carriage by rodents and prolonged shedding of cysts, together with elevated levels of calprotectin in the stool, confirms the capacity of this organism to cause disease and indicates dientamoebiasis should be considered in the differential diagnosis of gastrointestinal diseases such as Inflammatory Bowel Syndrome (IBS). "
8.	Tinidazole FDA Link 12/01/2012 - "Treatments reported to be successful for dientamoebiasis include carbarsone, diphetarsone, tetracyclines, paromomycin, erythromycin, hydroxyquinolines and the 5-nitroimidazoles, including metronidazole, secnidazole, tinidazole and ornidazole. "
9.	TetracyclinesIBA 12/01/2012 - "Treatments reported to be successful for dientamoebiasis include carbarsone, diphetarsone, tetracyclines, paromomycin, erythromycin, hydroxyquinolines and the 5-nitroimidazoles, including metronidazole, secnidazole, tinidazole and ornidazole. "
10.	Clioquinol (Vioform)FDA Link 01/01/2017 - "[Clioquinol use for Dientamoeba fragilis infections is questionable]."

Therapies and Procedures

1.	Therapeutics 06/01/2014 - "Metronidazole therapy for treating dientamoebiasis in children is not associated with better clinical outcomes: a randomized, double-blinded and placebo-controlled clinical trial."