delta-1-Pyrroline-5-Carboxylate Reductase

An enzyme that catalyzes the last step in proline biosynthesis which catalyzes the NADPH-dependent reduction of delta-1-pyrroline-5-carboxylate to L-Proline.

Also Known As:

delta-1-P-5-CRase; Enzyme, P5CR; Reductase, P5C; Reductase, delta-1-Pyrroline-5-Carboxylate; delta 1 P 5 CRase; delta 1 Pyrroline 5 Carboxylate Reductase; L-Pro-NAD(P)-5-Oxidoreductase; P5C Reductase; P5CR Enzyme

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on CH-NH Group Donors
      - Pyrroline Carboxylate Reductases
        delta-1-Pyrroline-5-Carboxylate Reductase: 7
        Arabidopsis P5CR protein
        E coli proC protein
        human PYCR1 protein
        human PYCR2 protein
        S cerevisiae PRO3 protein

Experts

1.	Forlani, Giuseppe: 2 articles (12/2021 - 06/2012)
2.	Petrollino, Davide: 2 articles (12/2021 - 06/2012)
3.	Borgatti, Monica: 1 article (12/2021)
4.	Hu, Chien-An A: 1 article (12/2021)
5.	Oscilowska, Ilona: 1 article (12/2021)
6.	Palka, Jerzy: 1 article (12/2021)
7.	Ragno, Daniele: 1 article (12/2021)
8.	Sabbioni, Giuseppe: 1 article (12/2021)
9.	Szoka, Lukasz: 1 article (12/2021)
10.	Chen, Shaochen: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2021 - "If a method of reducing or inhibiting P5C reductase could be discovered, it would provide new means of treating cancer. " 12/01/2021 - "Isozymes of P5C reductase (PYCR) in human diseases: focus on cancer." 12/01/2021 - "In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated. " 01/01/2020 - "Particularly, proline metabolism is critical for tumorigenesis since pyrroline-5-carboxylate (P5C) reductase (PYCR/P5CR) is highly expressed in various tumors and its enzymatic activity is essential for in vitro 3D tumor cell growth and in vivo tumorigenesis. " 12/01/2021 - "It is well established that proline synthesis enzymes, P5C synthetase and P5C reductase as well as collagen prolyl hydroxylases are up-regulated in most of cancer types and control rates of collagen biosynthesis. "
2.	Carcinogenesis 01/01/2020 - "Particularly, proline metabolism is critical for tumorigenesis since pyrroline-5-carboxylate (P5C) reductase (PYCR/P5CR) is highly expressed in various tumors and its enzymatic activity is essential for in vitro 3D tumor cell growth and in vivo tumorigenesis. "
3.	Starvation 06/01/2012 - "In both prokaryotic and eukaryotic microorganisms, unless an ornithine cyclodeaminase is present, the activity of δ1-pyrroline-5-carboxylate (P5C) reductase is mandatory to proline production, and the enzyme inhibition should result in amino acid starvation, blocking in turn protein synthesis. "
4.	Skin Neoplasms (Skin Cancer) 12/01/2021 - "In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated. "
5.	Retinal Degeneration 01/01/1982 - "In C3H retinal degeneration mice, P5C reductase activity in the retina and choroid was decreased to about one-third that of CRJ control mice in the specific activity after the tenth day. "

Related Drugs and Biologics

1.	Proline (L-Proline)
2.	Enzymes
3.	Isoenzymes
4.	Prolyl Hydroxylases (Prolyl Hydroxylase)
5.	Proteins (Proteins, Gene)
6.	Ligases (Synthetase)
7.	Collagen
8.	Amino Acids
9.	ornithine cyclodeaminase
10.	delta-1-pyrroline-5-carboxylate