Gap Junction alpha-4 Protein

A GAP JUNCTION alpha subunit containing four transmembrane domains expressed in the adipose cells and myocardium. Mutations in the human gene GJA4 are risk factors for ATHEROSCLEROSIS and MYOCARDIAL INFARCTION.

Also Known As:

Networked: 48 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Burt, Janis M: 6 articles (01/2020 - 11/2008)
2.	Good, Miranda E: 3 articles (10/2014 - 07/2011)
3.	Nelson, Tasha K: 3 articles (12/2013 - 11/2008)
4.	Yamada, Yoshiji: 3 articles (04/2004 - 12/2002)
5.	Yokota, Mitsuhiro: 3 articles (04/2004 - 12/2002)
6.	Piťha, J: 2 articles (12/2021 - 01/2010)
7.	Guo, Suxia: 2 articles (04/2015 - 10/2014)
8.	Yang, Zhenyu: 2 articles (04/2015 - 10/2014)
9.	Ek-Vitorín, José F: 2 articles (10/2014 - 07/2012)
10.	Simon, Alexander M: 2 articles (07/2011 - 11/2008)

Related Diseases

1.	Hemangiosarcoma (Angiosarcoma) 02/01/1997 - "In this study, we have analyzed mutations of the connexin 37 (Cx37) gene in rat hepatic angiosarcomas induced by vinyl chloride. " 02/01/1997 - "Connexin 37 mutations in rat hepatic angiosarcomas induced by vinyl chloride." 04/01/2000 - "In this study, we analyzed the presence of mutations in the connexin 37 (Cx37) gene in 22 human hepatic angiosarcomas, 6 and 4 of which were associated with exposure to vinyl chloride and Thorotrast, respectively. "
2.	Myocardial Infarction 01/01/2013 - "There is evidence showing the association between connexin 37 (Cx37) C1019T polymorphism and acute myocardial infarction (AMI). " 01/01/2013 - "Mutations of the connexin 37 and 40 gap-junction genes in patients with acute myocardial infarction." 04/01/2017 - "C1019T Polymorphism in the Connexin 37 Gene and Myocardial Infarction Risk in Premature Coronary Artery Disease." 01/01/2008 - "Recently, the C1019T polymorphism in the human gene encoding connexin 37 (CX37, encoded by GJA4) has been reported to be associated with coronary artery disease (CAD)/myocardial infarction in different racial groups, but no data are currently available in northern Han Chinese. " 12/12/2002 - "In a large-scale study involving the selected polymorphisms and the remaining 4152 subjects, similar logistic-regression analysis revealed that the risk of myocardial infarction was significantly associated with the C1019T polymorphism in the connexin 37 gene (P<0.001) in men and the 4G-668/5G polymorphism in the plasminogen-activator inhibitor type 1 gene (P<0.001) and the 5A-1171/6A polymorphism in the stromelysin-1 gene (P<0.001) in women. "
3.	Atherosclerosis 06/01/2011 - "The aim of our study was to evaluate a possible association between subclinical atherosclerosis in carotid arteries and the connexin 37 gene polymorphism (1019C>T; Pro319Ser) in a population of urban and rural women. " 01/01/2022 - "To investigate the mechanism of Connexin 37 (Cx37) and Kv1.3 pathways in atherosclerosis (AS). " 01/01/2022 - "Connexin 37 Regulates the Kv1.3 Pathway and Promotes the Development of Atherosclerosis." 04/01/2012 - "Connexin 37, encoded by the GJA4 gene, protects against atherosclerosis. " 06/01/2011 - "The association between subclinical atherosclerosis in carotid arteries and Connexin 37 gene polymorphism (1019C>T; Pro319Ser) in women."
4.	Atherosclerotic Plaque (Atheroma) 04/01/2015 - "The aim of this study was to examine the effects of connexin 37 (Cx37) interference on atherosclerotic plaques. " 04/01/2015 - "Reduction of connexin 37 expression by RNA interference decreases atherosclerotic plaque formation." 08/01/1999 - "A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development." 08/01/1999 - "In order to strengthen this premise, the aim of the present work was to probe for structural polymorphisms in connexin 37, a gap junctional protein uniquely expressed in endothelial cells, and to assess for potential genotypic segregation in individuals displaying atherosclerotic plaque. "
5.	Hyperalgesia 03/28/2002 - "Study results showed ipsilaterally increased connexin 37 mRNA levels proximally and distally in rat sciatic nerves after injury and behavioral thermal hyperalgesia at 7 and 14 days. " 03/28/2002 - "Sciatic nerve connexin 37 mRNA increases were proportional to the extent of thermal hyperalgesia, but skin, muscle, and lumbar spinal cord connexin 37 mRNA showed no significant changes. " 03/28/2002 - "Results indicate that upregulation of connexin 37 mRNA following sciatic nerve injury correlates with subsequent thermal hyperalgesia, which suggests that gap junctions (connexin 37) are responsible for the hyperexcitability following peripheral nerve injury."

Related Drugs and Biologics

1.	Vinyl Chloride (Chloroethylene)
2.	Connexins
3.	Connexin 43 (Connexin43)
4.	MicroRNAs (MicroRNA)
5.	Plasminogen Inactivators
6.	Thorium Dioxide (Thorotrast)
7.	Messenger RNA (mRNA)
8.	Nucleotides
9.	Gap Junction beta-1 Protein
10.	Peptides (Polypeptides)