Gap Junction alpha-5 Protein

A GAP JUNCTION alpha subunit containing four transmembrane domains expressed in the atrial myocardium and ventricular HEART CONDUCTION SYSTEM including PURKINJE FIBERS. Mutations in the human gene GJA5 are associated with cardiac conduction abnormalities such as a familial ATRIAL FIBRILLATION.

Also Known As:

Networked: 58 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kurtz, Armin: 5 articles (04/2015 - 08/2009)
2.	Wagner, Charlotte: 5 articles (03/2015 - 08/2009)
3.	Haefliger, Jacques-Antoine: 3 articles (06/2014 - 06/2005)
4.	Kurtz, Lisa: 3 articles (06/2011 - 08/2009)
5.	Chen, Wei: 2 articles (01/2017 - 01/2017)
6.	Guo, Yijun: 2 articles (01/2017 - 01/2017)
7.	Tong, Wusong: 2 articles (01/2017 - 01/2017)
8.	Yang, Wenjin: 2 articles (01/2017 - 01/2017)
9.	Zeng, Jinsong: 2 articles (01/2017 - 01/2017)
10.	Zheng, Ping: 2 articles (01/2017 - 01/2017)

Related Diseases

1.	Fibrosis (Cirrhosis) 06/20/2013 - "Overexpression of CREM-IbΔC-X in young TG mice (<8weeks) led to atrial dilatation combined with distension of myocardium, elongated myocytes, little fibrosis, down-regulation of connexin 40, loss of excitability with a number of depolarized myocytes, atrial ectopies and inducibility of AF. " 07/01/2012 - "Interstitial fibrosis was greater and connexin 40 expression was lower in DM than control. " 02/01/2011 - "[Association between myocardial connexin 40 and 45 expression and myocardial fibrosis in the rapid atrial pacing canine model]." 01/01/2013 - "TNF-α is involved in the pathogenesis of atrial fibrosis and altered connexin-40 expression in mice through the TGF-β signaling pathway, activation of myofibroblasts and increased secretion of MMPs. " 06/01/2011 - "Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43."
2.	Atrial Fibrillation 12/02/2015 - "A study of the association between the connexin 40 rs35594137 polymorphism and atrial fibrillation in Xinjiang Chinese Han and Uygur populations." 09/01/2023 - "Association between polymorphisms in connexin 40 gene (Cx40) and risk of atrial fibrillation: a meta-analysis based on 3,452 subjects." 10/17/2016 - "We aimed to elucidate the association between connexin 40 (Cx40) genetic polymorphisms and atrial fibrillation (AF) in a Chinese population in Xinjiang comprising Uyghur and Han individuals. " 10/17/2016 - "Association between -44G/A and +71A/G polymorphisms in the connexin 40 gene and atrial fibrillation in Uyghur and Han populations in Xinjiang, China." 10/01/2009 - "Absence of connexin 40 gene polymorphism, as a marker of undetected atrial fibrillation in patients with unexplained cerebral ischemic events."
3.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/2017 - "Corrigendum to "Involvement of autophagy in connexin 40 reduction in the late phase of traumatic brain injury in rats" [Brain Res. Bull. " 01/01/2017 - "Involvement of autophagy in connexin 40 reduction in the late phase of traumatic brain injury in rats." 01/01/2017 - "Here, we aimed to study whether autophagy, a stress-response process for recycling of intracellular proteins and organelles, is involved in the reduction of connexin 40 (Cx40) during the late phase of traumatic brain injury (TBI). "
4.	Intracranial Vasospasm 04/01/2020 - "The present study was performed to elucidate the role of nitric oxide (NO) and connexin 40 (Cx40) in the induction of cerebral vasospasm after subarachnoid hemorrhage (SAH) in vivo. " 04/01/2020 - "Upregulation of Connexin 40 Mediated by Nitric Oxide Attenuates Cerebral Vasospasm After Subarachnoid Hemorrhage via the Nitric Oxide-Cyclic Guanosine Monophosphate-Protein Kinase G Pathway."
5.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 04/01/2020 - "The present study was performed to elucidate the role of nitric oxide (NO) and connexin 40 (Cx40) in the induction of cerebral vasospasm after subarachnoid hemorrhage (SAH) in vivo. " 04/01/2020 - "Upregulation of Connexin 40 Mediated by Nitric Oxide Attenuates Cerebral Vasospasm After Subarachnoid Hemorrhage via the Nitric Oxide-Cyclic Guanosine Monophosphate-Protein Kinase G Pathway."

Related Drugs and Biologics

1.	Connexin 43 (Connexin43)
2.	Collagen
3.	Proteins (Proteins, Gene)
4.	Connexins
5.	rho-Associated Kinases
6.	Potassium
7.	Myosin-Light-Chain Phosphatase
8.	Inwardly Rectifying Potassium Channels (Inward Rectifier Potassium Channels)
9.	Adrenergic Receptors (Adrenergic Receptor)
10.	Protein Kinases (Protein Kinase)