Gap Junction beta-1 Protein

A GAP JUNCTION beta subunit containing four transmembrane domains expressed in myelinating SCHWANN CELLS and is localized to peripheral MYELIN (e.g., noncompact myelin in the paranode and Schmitt-Lanterman incisures). Mutations in the human gene GJB1 are associated with X-linked CHARCOT-MARIE-TOOTH DISEASE type 1 (CMT1X).

Also Known As:

Networked: 200 relevant articles (0 outcomes, 18 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yano, Tomohiro: 15 articles (01/2013 - 01/2003)
2.	Yamasaki, Hiroshi: 10 articles (06/2008 - 01/2003)
3.	Sato, Hiromi: 9 articles (06/2008 - 02/2005)
4.	Hagiwara, Hiromi: 8 articles (06/2008 - 02/2005)
5.	Ueno, Koichi: 8 articles (06/2008 - 07/2004)
6.	Negishi, Etsuko: 7 articles (08/2007 - 07/2004)
7.	Hagiwara, Kiyokazu: 7 articles (05/2006 - 05/2003)
8.	Fukumoto, Keiko: 6 articles (06/2008 - 02/2005)
9.	Fujimoto, Eriko: 6 articles (08/2007 - 07/2004)
10.	Takahashi, Satoru: 5 articles (12/2021 - 08/2007)

Related Diseases

1.	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 10/01/2002 - "To report a Chinese Charcot-Marie-Tooth disease (CMT) family whose proband had abnormal brainstem auditory evoked potentials (BAEPs) and to study its relationship with connexin 32 (Cx32) gene mutation. " 02/01/2001 - "The aim of the present study was to identify the mutations in the connexin 32 gene in French-Canadian families with X-linked Charcot-Marie-Tooth disease (CMTX). " 04/01/1998 - "X-linked Charcot-Marie-Tooth disease with connexin 32 mutations: clinical and electrophysiologic study." 09/14/2023 - "X-linked Charcot-Marie-Tooth disease type 1 (CMT1X) is a demyelinating neuropathy resulting from loss-of-function mutations affecting the GJB1/connexin 32 (Cx32) gene. " 06/15/2014 - "Four novel connexin 32 mutations in X-linked Charcot-Marie-Tooth disease. "
2.	Neoplasm Metastasis (Metastasis) 08/01/2007 - "However, overexpression of Cx32 protein in cytoplasm enhanced both the motility and the invasiveness of HuH7 cells and induced metastasis when the cells were xenografted into SCID mice. " 08/01/2007 - "Our results suggest that, while Cx32-mediated GJIC suppresses the development of HCCs, cytoplasmic Cx32 protein exerts effects favourable for HCC progression, such as invasion and metastasis, once the cells have acquired a malignant phenotype." 08/01/2007 - "Furthermore, when HuH7 Tet-off Cx32 cells were xenografted into the liver of SCID mice, only the mice to which no Dox was administered developed metastatic lesions, indicating that overexpression of cytoplasmic Cx32 protein induced metastasis of HuH7 cells. " 01/01/2007 - "Consequently, the aim of the present study was the evaluation of the expression of connexin 32 (Cx32) in primary breast tumors (PTs) and matched-paired metastases to lymph nodes (MLNs) in correlation with selected clinicopathological features. " 06/01/2008 - "The inhibitory effect of connexin 32 gene on metastasis in renal cell carcinoma."
3.	Neoplasms (Cancer) 01/01/2016 - "We examined the localization of connexin 32 (Cx32), a component of gap junctions, in 24-month-old male B6C3F1 mice with spontaneously occurring hepatocellular altered foci or tumors. " 12/01/2001 - "Frozen sections of 23 normal, 43 BPH and 40 cancer involved prostates were evaluated for the presence, staining intensity and pattern of connexin 32 and 43 by immunocytochemical testing. " 03/01/1998 - "These results suggest that PB, a liver tumor-promoting agent, inhibits hepatic GJIC in vivo in rats and that aberrant Cx32 protein expression and/or localization may be responsible for this effect." 09/01/1997 - "Loss of Cx32 protein from hepatic gap junctions is therefore likely to cause enhanced clonal survival and expansion of mutated ('initiated') cells, which results in a higher susceptibility to hepatic tumors. " 11/01/1994 - "These results indicate that Cx32 protein was posttranscriptionally downregulated in 7777 and H4IIE-C3 tumor cells. "
4.	Inflammation (Inflammations) 06/01/2015 - "We investigated connexin 32 (Cx32)-deficient mice, a model for the X-linked form of Charcot-Marie-Tooth neuropathy (CMT1X), regarding the impact of low-grade inflammation on Schwann cell phenotype. " 02/01/1996 - "Posttranscriptional regulation of connexin 32 expression in liver during acute inflammation." 01/15/2012 - "We demonstrate that connexin 32 (Cx32), a key hepatic gap junction protein, is an essential mediator of DILI by showing that mice deficient in Cx32 are protected against liver damage, acute inflammation and death caused by liver-toxic drugs. " 01/01/1999 - "Previous studies showed that the expression of connexin 32 (Cx32), the polypeptide subunit component of the major hepatic gap junction, is reduced in liver by changes in mRNA stability during bacterial lipopolysaccharide (LPS)-induced inflammation. "
5.	Carcinoma (Carcinomatosis) 11/01/1995 - "No malignant cells from patients with carcinoma contained detectable connexin 32. " 01/01/1990 - "Morphometrical analysis also showed that in most of the carcinomas the number of gap junction spots stained with connexin 32 antibody was not less than that in the surrounding livers. " 01/01/1990 - "No decrease in connexin 32 mRNA expression was found in carcinomas compared with the surrounding nontumorous tissue. " 08/01/1996 - "This study was conducted to examine the possible relationship among connexin 32 (Cx32) expression, cell proliferation and differentiation in the normal stomach, N-methyl-N'-nitro-nitrosoguanidine (MNNG)-induced atrophic gastritis, and carcinoma in rats. " 02/26/1993 - "To examine the potential of cytoplasmic portions ("tails") of desmosomal cadherins for assembly of desmosome plaque structures and anchorage of intermediate filaments (IFs), we transfected cultured human A-431 carcinoma cells, abundant in desmosomes and cytokeratin IFs, with constructs encoding chimeric proteins in which the transmembranous region of connexin 32 had been fused with tails of desmocollin (Dsc) or desmoglein (Dsg). "

Related Drugs and Biologics

1.	Connexin 43 (Connexin43)
2.	Proteins (Proteins, Gene)
3.	Messenger RNA (mRNA)
4.	Peptides (Polypeptides)
5.	Connexins
6.	Complementary DNA (cDNA)
7.	Doxorubicin (Adriamycin)
8.	Diethylnitrosamine (N-Nitrosodiethylamine)
9.	MicroRNAs (MicroRNA)
10.	2-Acetylaminofluorene (2 Acetylaminofluorene)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Liver Transplantation
3.	Therapeutics
4.	Intraperitoneal Injections