Rhinosinusitis

11/01/2022 - "The efficacy of topical corticosteroids is limited in chronic rhinosinusitis (CRS) due to rapid clearance from the nasal cavity and insufficient drug delivery to inflamed sinonasal passages. "
10/12/2019 - "Compared with 11 patients without eosinophilic chronic rhinosinusitis (ECRS), 16 patients with ECRS showed significantly improved systemic corticosteroid-sparing effects [- 71.3 ± 37.0% vs - 10.7 ± 20.1%, P = 0.006], change from baseline FeNO [- 19 ± 57 (%) vs 30 ± 77 (%), P = 0.023] and symptoms [14 patients (88%) vs five patients (45%), P = 0.033]. "
01/01/2011 - "Treatment with local nasal corticosteroids in combination with isotonic NaCl solutions produces a significant reduction in the severity of symptoms in patients with rhinosinusitis. "
01/01/2013 - "Corticosteroids are the mainstay of treatment for refractory chronic rhinosinusitis. "
03/01/2012 - "Corticosteroids are a mainstay of treatment for chronic rhinosinusitis with nasal polyposis (CRSwNP). "

02/01/2013 - "Oral antibiotics can be prescribed most confidently for the management of chronic rhinosinusitis when purulent exacerbations of disease are detected endoscopically and antibiotic choices are directed by culture. "
04/26/2016 - "We found very little evidence that systemic antibiotics are effective in patients with chronic rhinosinusitis. "
01/01/2010 - "The addition of INCSs to oral antibiotics has been proven to be more effective than antibiotics alone for achieving symptomatic improvement in patients with acute rhino sinusitis. "
10/01/2013 - "Antibiotics are not beneficial for patients with clinically diagnosed uncomplicated acute rhinosinusitis."
02/01/2013 - "There is no high-level experimental evidence to support the use of oral antibiotics in the management of chronic rhinosinusitis. "

01/01/2019 - "Intranasal steroids have become part of the mainstay in the long-term management of chronic rhinosinusitis. "
02/01/2014 - "Steroid-eluting implants are well tolerated and an effective addition to the armamentarium utilized in the management of chronic rhinosinusitis. "
01/01/2019 - "This study systematically reviews the literature on the efficacy of steroids for non-chronic rhinosinusitis (CRS)-related olfactory loss and provides recommendations. "
01/01/2018 - "The goal of this study was to perform a systematic review with meta-analysis of the efficacy of steroid nasal irrigation on post-operative management of Chronic rhinosinusitis (CRS) following ESS. "
05/01/2023 - "Efficacy of Steroid-Impregnated Spacers After Endoscopic Sinus Surgery in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis."

10/17/2023 - "The introduction of biologics in the management of chronic rhinosinusitis with nasal polyposis (CRSwNP) has allowed new therapeutic options and Dupilumab represents the first approved biological agent. "
11/11/2022 - "Dupilumab has been shown to be safe and effective in treating chronic rhinosinusitis with polyposis (CRSwNP). "
01/01/2024 - "Long-Term Efficacy of Dupilumab for Eosinophilic Chronic Rhinosinusitis."
05/01/2021 - "Our objective was to evaluate the efficacy of dupilumab in AERD patients with uncontrolled, chronic rhinosinusitis with nasal polyposis (CRSwNP). "
01/01/2024 - "In recent years, dupilumab has been available for the treatment of refractory chronic rhinosinusitis since 2020 in Japan. "

01/01/2014 - "The treatment of chronic rhinosinusitis with liposomal nasal spray results in a similar, significant reduction of symptoms and significant improvement in quality of life as guideline-recommended treatment and is therefore a comparable alternative. "
11/01/2007 - "Buffered physiological and buffered hypertonic saline nasal sprays both improve mucociliary clearance, which is beneficial for treatment of rhinosinusitis. "
05/01/2008 - "Thermal water (Salsomaggiore Italy) nasal spray showed a greater efficacy with respect to saline in the treatment of patients affected by chronic rhinosinusitis."
10/01/2022 - "The aim of our study has been to evaluate the efficacy of the administration of nebulized HA through a nasal douche compared with its administration through a nasal spray with patients undergoing ESS for chronic rhinosinusitis. "
01/01/2023 - "This study aims to compare the potential sinus distribution between high-volume nasal irrigation and nasal spray in chronic rhinosinusitis (CRS) patients who have not undergone sinus surgery. "

04/01/2009 - "Macrolides can be clinically effective in chronic rhinosinusitis (CRS). "
05/01/2015 - "The efficacy of macrolides in chronic rhinosinusitis (CRS) is still under controversy. "
09/01/2005 - "[Medical management of chronic rhinosinusitis with macrolides]."
06/01/2017 - "Further study using a placebo-controlled design evaluating the use of macrolides in clearly defined chronic rhinosinusitis populations is needed."
06/01/2017 - "The purpose of this systematic review was to evaluate new evidence along with previously reported studies of the use of macrolides in the treatment of chronic rhinosinusitis. "

10/01/2022 - "Efficacy of Topical High Volume Budesonide Nasal Irrigation in Post FESS Patients of Chronic Rhinosinusitis With or Without Nasal Polyposis."
03/01/2016 - "Off-label high-volume sinonasal budesonide irrigations are commonly used during the management of chronic rhinosinusitis (CRS). "
12/01/2008 - "Safety of budesonide in saline sinonasal irrigations in the management of chronic rhinosinusitis with polyposis: lack of significant adrenal suppression."
01/01/2018 - "Recent studies suggest that budesonide added to saline nasal lavage can be an effective treatment for patients with chronic rhinosinusitis (CRS). "
03/01/2009 - "Our findings suggest that using budesonide nasal wash may be clinically effective in decreasing the symptoms of chronic rhinosinusitis and does so without suppression of the hypothalamic-pituitary-adrenal axis in patients with chronic rhinosinusitis."

03/01/2014 - "Short-term, high-dose clarithromycin appears to be more effective for the treatment of chronic rhinosinusitis than low-dose clarithromycin."
03/01/2018 - "Clarithromycin in the Management of Chronic Rhinosinusitis: Preliminary Results of a Possible Its New Use."
05/01/2021 - "There is no consensus in the literature regarding the effectiveness of clarithromycin in patients with chronic rhinosinusitis with sinonasal polyposis and the national literature does not report any prospective studies on the efficacy of clarithromycin in chronic rhinosinusitis in our population. "
01/01/2019 - "The aim of this systematic review (SR) was to assess the safety and efficacy of oral clarithromycin for the treatment of chronic rhinosinusitis (CRS). "
01/01/2003 - "[Efficacy of clarithromycin (Fromilid) in treatment of uncomplicated acute bacterial rhinosinusitis in children]."

12/01/2021 - "Randomised controlled trials (RCTs) with at least three months follow-up comparing biologics (monoclonal antibodies) against placebo/no treatment in patients with chronic rhinosinusitis. "
01/01/2020 - "Randomised controlled trials (RCTs) with at least three months follow-up comparing biologics (currently, monoclonal antibodies) against placebo/no treatment in patients with chronic rhinosinusitis. "
01/13/2021 - "[Chronic rhinosinusitis with nasal polyps : is there a place for monoclonal antibodies in 2020 ?]"
01/01/2021 - "Real-Life Experience of Monoclonal Antibody Treatments in Chronic Rhinosinusitis with Nasal Polyposis."
01/01/2018 - "Monoclonal antibodies for the treatment of chronic rhinosinusitis with nasal polyposis: a systematic review."

12/01/2022 - "Adult patients with eosinophilic chronic rhinosinusitis received 100mg mepolizumab subcutaneously at four-weekly intervals for 24 weeks in this prospective phase 2 clinical trial. "
01/01/2019 - "This study was a 48-week prospective open-label analysis of mepolizumab in 11 asthmatics with chronic rhinosinusitis (CRS). "
10/01/2023 - "Mepolizumab in chronic rhinosinusitis with nasal polyposis."
01/01/2023 - "Der Anti-IL-5-Antikörper Mepolizumab ist seit November 2021 als Zusatztherapie zu intranasalen Glukokortikosteroiden für die Behandlung Erwachsener mit schwerer chronischer Rhinosinusitis mit Nasenpolypen zugelassen, wenn systemische Glukokortikosteroide oder eine Operation keine ausreichende Krankheitskontrolle bewirken. "
01/01/2020 - "Eosinophil paradox with mepolizumab in chronic rhinosinusitis with nasal polyposis."

03/01/2006 - "These striking differences provide new opportunities for improved therapy of chronic rhinosinusitis and polyposis as well as extended use of the nose for delivery of drugs from the nose into the brain."
08/01/1999 - "We conclude that antileukotriene therapy is an effective treatment for most patients whose symptoms of chronic rhinosinusitis persist following sinus surgery."
03/01/2013 - "A complete understand of topical drug delivery is increasingly essential to the management of chronic rhinosinusitis when traditional forms of medical therapy and surgery have failed."
05/01/2018 - "NSI may provide benefit for ARS in children; however, additional high-quality studies with defined outcome measures are needed to determine the quantitative efficacy of this therapy in the pediatric patients with rhinosinusitis-especially in pediatric CRS."
05/01/2010 - "This study demonstrated a significant improvement in chronic rhinosinusitis symptoms after a six-session course of pulsed ultrasound therapy. "

11/01/2018 - "The purpose of this study was to evaluate the effectiveness, safety and correct indication about the use of BCD and a non-absorbable stent (Relieva Stratus™ MicroFlow spacer) in the management of chronic rhinosinusitis (CRS) of the frontal sinus. "
04/01/2020 - "Implantation of sinus stents and spacers can be used as adjuvant management to maintain patency of sinuses after endoscopic sinus surgery for chronic rhinosinusitis. "
10/01/2019 - "Lacrimal Diversion Devices (Sinopsys Lacrimal Stent): Sharing our Experience with Patients with Chronic Rhinosinusitis without Polyposis."
11/01/2008 - "We evaluated postoperative MMP-9 levels, bacterial colonization, healing quality, and symptom scores in patients suffering from chronic rhinosinusitis with (CRSwNP) and without nasal polyposis (CRSsNP) (n=10) who underwent functional endoscopic sinus surgery during which the DC-releasing and placebo stents were placed. "
11/01/2004 - "Evidence of bacterial biofilms on frontal recess stents in patients with chronic rhinosinusitis."

12/01/2006 - "There have been no recent significant changes in the medical or surgical management of chronic rhinosinusitis other than the rationale of performing an adenoidectomy prior to endoscopic sinus surgery for eradication of biofilms. "
04/01/2004 - "Adenoidectomy was proved to be effective in the management of pediatric rhinosinusitis in this series. "
08/01/2022 - "While adenoidectomy is the first-line surgical management of chronic rhinosinusitis (CRS) in young children, evidence regarding its utility in older children is lacking. "
08/01/2022 - "Efficacy of Adenoidectomy for the Management of Chronic Rhinosinusitis in Children Older Than 7 Years of Age."
09/01/2007 - "Sixteen patients (48%) with recurrent episodes of rhinosinusitis required adenoidectomy Seven (21%) required a functional endoscopic sinus surgery (FESS), and 6 (86%) improved after FESS. "

09/29/2020 - "Chronic rhinosinusitis (CRS) negatively affects quality of life (QoL), and balloon catheter sinuplasty (BCS) has shown good outcomes in adult patients. "
03/01/2018 - ":Balloon catheter dilation in the treatment of chronic rhinosinusitis is safe and effective. "
01/01/2016 - "Paranasal sinus balloon catheter dilation (BCD) represents a commonly used tool in the management of chronic rhinosinusitis (CRS) for which the indications, utilization, and outcomes have not been well established. "
03/01/2018 - "[The possible failing reasons of balloon catheter dilation procedure in the management of chronic rhinosinusitis]."
01/01/2018 - "Use of balloon catheter dilation vs. traditional endoscopic sinus surgery in management of light and severe chronic rhinosinusitis of the frontal sinus: a multicenter prospective randomized study."

03/01/2014 - "Systematic review of immunotherapy for chronic rhinosinusitis."
04/01/2009 - "Our results might help to choose immunotherapy to combine with endoscopic sinus surgery for those selected patients to improve the outcomes of chronic rhinosinusitis."
02/01/2009 - "To review the literature on the role of fungi in chronic rhinosinusitis (CRS) pathogenesis and the effect of antifungal drug therapy and antifungal immunotherapy. "
03/01/2014 - "Immunotherapy (IT) has been well established as an effective treatment for allergic rhinitis (AR), but little is known about the benefits of IT on clinical outcomes of comorbid chronic rhinosinusitis (CRS). "
03/01/2021 - "The role of house dust mite immunotherapy in Indonesian children with chronic rhinosinusitis allergy: A randomized control trial."