Surfactant protein A and D in chronic rhinosinusitis with nasal polyposis and corticosteroid response.

Abstract

BACKGROUND:

Corticosteroids are a mainstay of treatment for chronic rhinosinusitis with nasal polyposis (CRSwNP). Data related to the effect of systemic methylprednisolone on surfactant protein (SP) expression in CRSwNP is limited. This study aimed to reveal the consequences of systemic methylprednisolone treatment on levels of SP-A and SP-D, which play a role in innate immunity, in patients with CRSwNP.

METHODS:

Twenty-one patients with CRSwNP were included in the study, along with 15 control patients scheduled for dacryocystorhinostomy. A polypoid tissue biopsy was taken under local anesthesia, and 15 CRSwNP patients were scheduled for endoscopic sinus surgery after 3 weeks of oral methylprednisolone. Posttreatment biopsies were performed perioperatively. Pre- and posttreatment endoscopic polyp grades were determined, as were symptom scores regarding nasal obstruction, headache, and nasal discharge using a visual analog scale (VAS). SP-A and SP-D levels were measured using enzyme-linked immunosorbent assay and the results were compared.

RESULTS:

All patients reported relief from clinical symptoms through VAS after methylprednisolone treatment. The posttreatment polyp grade was reduced (p < 0.0001). SP-A and SP-D levels did not yield a significant difference between CRSwNP patients and controls (p = 0.25 and p = 0.13, respectively). Statistically significant up-regulation was detected in SP-A and SP-D levels after oral methylprednisolone (p = 0.0002 and p = 0.0004, respectively).

CONCLUSION:

In this study, significant up-regulation of SP-A and SP-D was revealed in patients with CRSwNP after systemic steroid treatment. The role of SP-A and SP-D up-regulation in CRSwNP pathogenesis and therapeutic outcomes of corticosteroids have potential importance for the introduction of new therapeutic modalities that are more effective and produce fewer adverse effects.

• Authors: Serkan Salman, Meltem Esen Akpinar, Ozgur Yigit, Uzay Gormus
• Journal: American journal of rhinology & allergy (Am J Rhinol Allergy) 2012 Mar-Apr Vol. 26 Issue 2 Pg. e76-80 ISSN: 1945-8932 [Electronic] United States
• PMID: 22487281 (Publication Type: Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Pulmonary Surfactant-Associated Protein A
• Pulmonary Surfactant-Associated Protein D
• Methylprednisolone

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Chronic Disease
• Disease Progression
• Humans
• Immunity, Innate (drug effects)
• Methylprednisolone (administration & dosage, adverse effects)
• Nasal Mucosa (drug effects, metabolism)
• Nasal Polyps (complications, drug therapy, immunology)
• Pulmonary Surfactant-Associated Protein A (genetics, metabolism)
• Pulmonary Surfactant-Associated Protein D (genetics, metabolism)
• Rhinitis (complications, drug therapy, immunology)
• Sinusitis (complications, drug therapy, immunology)
• Treatment Outcome
• Up-Regulation