Enhancer RNAs

01/01/2023 - "This study demonstrated the roles of eRNAs in the occurrence and development of PitNETs and revealed that ciclopirox was a potential therapeutic for pituitary adenomas."

07/15/2022 - "In this study, we mainly applied the Cancer Genome Atlas (TCGA) dataset to systematically discover crucial eRNAs involving UCEC. "
03/01/2022 - "This study provides insights into the impact of the enhancer RNA (eRNA) landscape on patient outcome, the immune microenvironment, and drug response across cancers and develops a multidimensional data portal to facilitate eRNA research."
01/01/2022 - "Growing studies have indicated that eRNAs could regulate cellular activities in various tumors. "
09/30/2021 - "Collectively, our study suggests that noncoding RNAs such as THUMPD3-AS1 and LINC01572 (i.e., putative eRNAs) can promote the transcription of genes involved in cell proliferation and differentiation and that the dysregulation of these noncoding RNAs can cause cancers such as HCC."
01/01/2021 - "In this study, we identified 124 prognosis-related eRNAs by analyzing The Cancer Genome Atlas (TCGA) datasets. "

01/01/2022 - "In this study, we identified a key enhancer RNA (eRNA) region in breast cancer (BRCA) by applying an integrated analysis method. "
01/01/2021 - "In this study, we focused on the crucial eRNAs that participate in immune responses in invasive breast cancer (IBC). "
01/01/2022 - "The ectopic expression of a targeted eRNA controlling the expression of an oncogene resulted in increased cell proliferation, demonstrating the regulatory potential of eRNAs in breast cancer."
12/01/2018 - "Oestrogen-associated eRNAs are closely related to breast cancer. "
10/01/2023 - "However, research on the evaluation of the prognostic value and molecular mechanisms of genomic instability associated eRNAs in breast cancer is long overdue. "

10/15/2021 - " this study, we have used a novel approach to screened key eRNAs in gastric cancer. "
01/01/2023 - "We identified three unique epigenetic clusters of STAD through the differential activation of super-enhancers, and identified Cluster B with a higher immune infiltrating and a better prognosis, which provides a novel understanding of eRNAs and potential clinical applicability of eRNA-based molecular subtypes in gastric cancer."
01/01/2023 - "The landscape of enhancer RNA identify prognosis-related molecular subtypes in gastric cancer."
01/01/2022 - "Methods: We used Cox survival and relevance analysis to identify the candidate eRNAs in gastric cancer and performed Gene Ontology and Reactome pathway enrichment to determine the potential functions of eRNAs. "
10/15/2021 - "However, the role of eRNAs in gastric cancer, especially the prognosis-associated eRNAs, has not been studied yet.In"

10/01/2023 - "Among these genes, F11R, BHLHE40, and NECTIN4 are previously reported oncogenes and EGOT is a tumor suppressor gene, indicating the direct roles of eRNAs in tumorigenesis."
10/10/2022 - "The functional alterations of eRNAs have been reported to be correlated with tumorigenesis. "
05/26/2021 - "Emerging evidence shows that eRNAs play important roles in enhancer activation and enhancer-driven gene regulation, and the expression of eRNAs may be a critical factor in tumorigenesis. "
01/01/2022 - "Repression of enhancer RNA PHLDA1 promotes tumorigenesis and progression of Ewing sarcoma via decreasing infiltrating T-lymphocytes: A bioinformatic analysis."
12/01/2018 - "In view of the gender differences in bladder cancer (BCa), we suppose that oestrogen-associated eRNAs are also involved in tumorigenesis of BCa. "