Ciclopirox (Loprox)

A cyclohexane and pyridinone derivative that is used for the treatment of fungal infections of the skin and nails, and for treatment of VAGINAL YEAST INFECTIONS.

Also Known As:

Loprox; Penlac; 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolamine salt; Batrafen; Ciclopirox Olamine; Ciclopiroxolamine; Cyclopirox; Cyclopyroxolamine; Dafnegin-CSC; HOE 296; HOE-296; Dafnegin CSC; HOE296; 2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-

Networked: 287 relevant articles (59 outcomes, 65 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Gupta, Aditya K: 17 articles (05/2022 - 05/2002)
2.	Gupta, A K: 11 articles (09/2005 - 01/2000)
3.	Skinner, Alayne R: 5 articles (07/2005 - 01/2003)
4.	Lu, Bin: 4 articles (01/2022 - 01/2020)
5.	Huang, Shile: 4 articles (01/2021 - 11/2010)
6.	Schaller, Martin: 4 articles (12/2017 - 06/2003)
7.	Tatsumi, Yoshiyuki: 4 articles (10/2017 - 04/2013)
8.	Cooper, Elizabeth A: 4 articles (03/2012 - 09/2003)
9.	Baran, R: 4 articles (07/2009 - 10/2000)
10.	Chen, Qin: 3 articles (01/2022 - 01/2020)

Related Diseases

1.	Onychomycosis (Tinea Unguium) 03/01/2006 - "Congenital candidal onychomycoses: effective cure with ciclopirox olamine 8% nail lacquer." 09/01/1991 - "This study indicates that 8% ciclopirox olamine nail liquor, with its satisfactory efficacy and lack of side effects, is a good remedy for onychomycosis." 05/01/2002 - "It was concluded that ciclopirox 8% nail lacquer, which has recently become available in the larger size of 6.6 mL, is a cost-effective agent for the management of toenail onychomycosis." 08/01/2001 - "Ciclopirox nail lacquer is safe and effective for the topical treatment of onychomycosis in patients with diabetes and produced results similar to those observed in the general population." 02/01/2016 - "The results of this study, and of a previous pivotal study versus the insoluble formulation of ciclopirox 8%, led to consider P-3051 as the gold standard for the topical treatment of mild-to-moderate onychomycosis. "
2.	Seborrheic Dermatitis 01/01/2006 - "Varying frequencies and concentrations of ciclopirox shampoo have been shown to be effective and safe in the treatment of seborrheic dermatitis of the scalp." 01/01/2003 - "In a placebo-controlled, double-blind clinical study, we demonstrated that antifungal ciclopiroxolamine (CIC) 1% cream was effective in mild to moderate facial seborrheic dermatitis. " 07/01/2004 - "Ciclopirox shampoo 1% is effective and safe in the treatment of seborrheic dermatitis of the scalp." 09/01/2003 - "Ciclopirox gel is effective and safe in the treatment of seborrheic dermatitis of the scalp." 07/01/2004 - "Safety and efficacy of ciclopirox 1% shampoo for the treatment of seborrheic dermatitis of the scalp in the US population: results of a double-blind, vehicle-controlled trial."
3.	Infections 05/01/2007 - "Ciclopirox 8% nail lacquer was safe, with treatment-related adverse events limited to infection in one patient, which resolved in 15 days; the patient completed the study. " 01/01/2019 - "Therefore, orally-administered ciclopirox may provide a novel opportunity to combat chronic HBV infection by blocking HBV capsid assembly." 01/01/2018 - "These results support further development of ciclopirox olamine as a repurposed topical agent for HSV infections." 01/01/2018 - "In addition, treatment with ciclopirox olamine significantly reduced acute and latent HSV-1 infection of the peripheral nervous system. " 07/01/2015 - "Ciclopirox olamine cream 1% is a safe and feasible treatment for superficial cutaneous mycotic infections, especially Candida spp. infection, in children aged between 3 months and 10 years."
4.	Tinea Pedis (Athlete's Foot) 09/01/2003 - "Ciclopirox, a broad-spectrum hydroxypyridone antifungal, has proven efficacy against the organisms commonly implicated in tinea pedis; Trichophyton rubrum, T.mentagrophytes and Epidermophyton floccosum. " 09/01/2003 - "Ciclopirox gel 0.77% applied twice daily for 4 weeks is an effective treatment of moderate interdigital tinea pedis due to T. " 09/01/2003 - "Two multicenter, double-blind, clinical studies compared the efficacy and safety of ciclopirox gel with that of its vehicle base in subjects with moderate interdigital tinea pedis with or without plantar involvement. " 09/01/2003 - "Ciclopirox gel in the treatment of patients with interdigital tinea pedis." 05/01/1989 - "Ciclopirox olamine lotion 1% was found to be significantly more effective than its vehicle in the treatment of patients with common tinea pedis. "
5.	Tinea (Ringworm) 01/01/1987 - "Observations on effects of ciclopirox olamine on dermatophytosis." 02/01/1986 - "Ciclopiroxolamine's action has been evaluated in 20 cases of dermatophytosis. " 01/01/1981 - "[Comparative double-blind study on ciclopiroxolamine cream and placebo cream in dermatophytoses (author's transl)]." 07/01/2005 - "Evaluation of the efficacy of ciclopirox 0.77% gel in the treatment of tinea pedis interdigitalis (dermatophytosis complex) in a randomized, double-blind, placebo-controlled trial." 01/01/1986 - "Multicentre double-blind clinical trials of ciclopirox olamine cream 1% in the treatment of tinea corporis and tinea cruris."

Related Drugs and Biologics

1.	Terbinafine (Lamisil)
2.	Antifungal Agents
3.	Solutions
4.	Ketoconazole (Nizoral)
5.	amorolfine
6.	Clotrimazole (Lotrimin)
7.	Ciclopirox (Loprox)
8.	Itraconazole (Sporanox)
9.	Fluconazole (Zonal)
10.	Miconazole (Monistat)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Ovariectomy (Oophorectomy)
4.	Lasers (Laser)