Secreted Frizzled-Related Proteins

01/01/2017 - "In this study we analyzed gene expression, promoter methylation and survival data from over 8000 tumour and normal samples from 29 cancers in order to map the context-specific associations of SFRPs 1-5 with patient survival, gene silencing and gene expression signatures. "
10/01/2023 - "This review aims to summarize the current knowledge of SFRPs in cancer, focusing on their expression patterns and their potential as novel therapeutic targets."
10/01/2023 - "Therefore, a review of the expression of various members of the SFRPs family in different cancers and their potential as therapeutic targets is warranted. "
10/01/2023 - "Despite the potential of SFRPs as a therapeutic target, the effects of SFRPs on tumor development remain unclear. "
10/01/2023 - "However, SFRPs are often silenced by promoter methylation in cancer cells, resulting in hyperactivation of the Wnt pathway. "

03/01/2010 - "The primary purpose of the study was to discuss the relationship between the expression of SFRPs and the clinicopathologic features of colorectal cancer (CRC). "
03/01/2010 - "However, SFRPs has not been systematically studied in colorectal tumors. "
08/31/2023 - "Despite the accumulation of evidence that indicated that SFRPs are differentially expressed and play a key role in various malignancies, the function of different SFRPs in colorectal cancer (CRC) remains insufficiently studied. "
07/24/2007 - "The mRNA expression of sFRPs and WIF-1 genes was absent or significantly downregulated (P < 0.01) when they were methylated in two colorectal cancer cell lines. "
08/01/2012 - "DNA methylation, involving APC, SFRPs and mutated in colorectal cancer (MCC), may bridge the mutational gap of APC or β-catenin for activating Wnt signalling in serrated adenomas of the colorectum."

01/01/2021 - "The methylation status of SFRPs was examined in gastric cancer specimens by quantitative methylation analysis. "
05/01/2012 - "Analysis of general expression revealed that overexpression of SFRPs repressed Wnt target gene expression and induced changes in the proliferation and apoptosis related genes in human gastric cancer cells. "
10/08/2007 - "We determined the frequency and functional significance of SFRPs hypermethylation in human gastric cancer. "
06/03/2021 - "We investigated the differential expression, prognostic value, and immune cell infiltration of SFRPs in gastric cancer patients from the Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, Kaplan-Meier plotter, cBioPortal, STRING, Gene-MANIA, DAVID, MethSurv, and TIMER databases. "
10/08/2007 - "Among the four SFRPs, only SFRP2 was significantly downregulated in gastric cancer as compared to adjacent non-cancer samples (P<0.01). "

12/01/2009 - "Our data suggest that promoter hypermethylation of SFRPs is associated with cervical adenocarcinoma, which could be used for molecular screening of cervical adenocarcinoma in the future. "
12/01/2009 - "Here, we want to further investigate the methylation status and function of SFRPs in adenocarcinoma of uterine cervix. "
01/01/2019 - "In the present study, we re-analyzed the expression pattern of SFRPs in Gene Expression Omnibus (GEO) datasets and evaluated the expression of SFRP4 at protein level in both KrasG12D/+; Trp53R172H/+; Pdx1-Cre; (KPC) mice and human pancreatic ductal adenocarcinoma (PDAC) tissue. "
12/01/2009 - "The methylation status of SFRPs was assessed in 23 adenocarcinomas (AC), and 45 normal control swabs by methylation-specific polymerase chain reaction and bisulfite sequencing. "
09/10/2005 - "Hypermethylation of secreted frizzled-related proteins (SFRP) genes frequently occurs with several cancers but has not been studied in esophageal adenocarcinoma or its precursor-Barrett's esophagus. "

08/01/2014 - "In this study, we sought to determine the clinical significance and underlying mechanism of HBx-induced SFRPs dysregulation in hepatoma cells and HBV-HCC patients. "
08/01/2014 - "However, dysregulation of SFRPs induced by hepatitis B virus (HBV) X protein (HBx) has never been studied in HBV-related hepatocellular carcinoma (HBV-HCC). "
03/01/2013 - "Frequent concomitant epigenetic silencing of SOX1 and secreted frizzled-related proteins (SFRPs) in human hepatocellular carcinoma."