Drug Fever

Drug-induced fever.

Also Known As:

Drug Induced Fever; Drug Induced Hyperthermia; Drug-Induced Fevers; Drug-Induced Hyperthermias; Fever, Drug; Fever, Drug-Induced; Hyperthermia, Drug-Induced; Drug-Induced Fever; Drug-Induced Hyperthermia

Networked: 240 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Immune System Diseases: 4321
- Hypersensitivity: 76867
  - Delayed Hypersensitivity: 3378
    - Drug Fever: 240
Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Body Temperature Changes: 152
    - Fever: 39160
      - Drug Fever: 240
Chemically-Induced Disorders: 2
- Drug-Related Side Effects and Adverse Reactions: 13596
  - Drug Hypersensitivity: 1536
    - Drug Fever: 240

Related Diseases

1.	Fever (Fevers)
2.	Hydrothorax
3.	Exanthema (Rash)
4.	Hypersensitivity (Allergy)
5.	Neoplasms (Cancer)

Experts

1.	Koh, Young-Il: 2 articles (07/2021 - 02/2011)
2.	Mancano, Michael A: 2 articles (04/2018 - 06/2016)
3.	Cunha, Burke A: 2 articles (08/2016 - 11/2006)
4.	Oka, Mikio: 2 articles (02/2016 - 01/2010)
5.	Kuhn, Donald M: 2 articles (11/2010 - 02/2005)
6.	Thomas, David M: 2 articles (11/2010 - 02/2005)
7.	Clemens, Kelly J: 2 articles (01/2007 - 08/2003)
8.	Cornish, Jennifer L: 2 articles (01/2007 - 08/2003)
9.	Hunt, Glenn E: 2 articles (01/2007 - 08/2003)
10.	McGregor, Iain S: 2 articles (01/2007 - 08/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Drug Fever:

1.	Anti-Bacterial Agents (Antibiotics)IBA 08/01/2019 - "The local hospital diagnosed it as drug fever and stopped all antibiotics. " 05/01/2011 - "Antibiotic drug-fever was suspected and antibiotics were stopped. " 09/01/1989 - "The incidence and clinical features of drug fever induced by antibiotics were investigated. " 09/01/1989 - "Clinical study of drug fever induced by parenteral administration of antibiotics." 03/01/1996 - "In 1994 there was stated the drug fever in 37 patients, 35 of them being treated without observation of the principles of rational antibiotic therapy. "
2.	Vancomycin FDA LinkGeneric 01/01/2021 - "Thereafter, his fever promptly improved, which indicated that the cause of persistent fever was vancomycin drug fever. " 02/01/1999 - "To our knowledge this is the first case documenting drug fever as a principal component of vancomycin-induced neutropenia, and provides further evidence in support of an immune-mediated mechanism." 06/01/2015 - "In addition, a total of 12 adverse reactions were observed in the vancomycin group; two for hepatotoxicity, one for nephrotoxicity, eight for leukopenia, two for skin rash, and one for drug fever. " 02/01/1999 - "A 39-year-old woman being treated for osteomyelitis with vancomycin developed severe neutropenia and drug fever. " 09/01/2009 - "Patients were included if they experienced drug-induced fever (ie, "drug fever"), rash, or neutropenia during vancomycin treatment. "
3.	favipiravirIBA 04/01/2021 - "We herein report this case of drug fever caused by favipiravir." 04/01/2021 - "Since he was in good overall health and no concomitant symptoms and signs were apparent, we considered it to be drug fever due to favipiravir. " 05/01/2021 - "Since the fever was relieved by discontinuation of favipiravir, and based on positive results with a drug-induced lymphocyte stimulation test, we diagnosed her with favipiravir-induced drug fever. " 05/09/2021 - "Here, we present a case of favipiravir-induced drug fever in a young adult coronavirus disease 2019 patient." 05/09/2021 - "Favipiravir-Induced Drug Fever in a Young Adult COVID-19 Patient."
4.	Methyldopa (Aldomet)FDA LinkGeneric 01/01/1978 - "Alpha-methyldopa and drug fever. " 05/11/1967 - "[Methyldopa-drug fever]." 10/01/1965 - "[Febrile reaction ("drug fever") due to alpha-methyldopa]." 10/01/1977 - "Of 6 patients on methyldopa, one developed drug fever (and was dropped from the study) and one developed impotence. " 02/01/1979 - "Though drug fever from methyldopa is well known, to my knowledge fever and hypotension simulating septic shock have never been described in this country as a syndrome resulting from methyldopa therapy. "
5.	beta Lactam AntibioticsIBA 01/01/2020 - "Evaluating drug fever to beta-lactam antibiotics." 10/01/1994 - "We initiated a study to determine the relative frequency of allergic reactions, ie, drug-induced fever and rash, to parenteral beta-lactam antibiotics in adult patients with cystic fibrosis. " 11/01/2006 - "Beta-lactam antibiotics may be used safely for patients with unknown/possible penicillin allergy and drug fever or rash. "
6.	Methamphetamine (Desoxyn)FDA LinkGeneric 02/01/2005 - "These results suggest that tolerance to methamphetamine neurotoxicity is associated with attenuated microglial activation and they further dissociate its neurotoxicity from drug-induced hyperthermia." 10/29/1993 - "In conclusion, (1) methamphetamine-induced hyperthermia per se is a stressful stimulant causing neuronal induction of HSP72 in the hippocampus neurons, particularly of CA1/2 and medial CA3 sectors, but does not prove fatal to the cells; (2) there is a cell type-specific difference in response to hyperthermic insult by inducing HSP72 and the timing of the induction response in the hippocampal formation; and (3) the animals that underwent drug-induced hyperthermia may be useful as an experimental model for the study of the protective mechanism of heat shock proteins against subsequent harmful stimuli."
7.	Tigecycline (Tygacil)FDA Link 11/01/2015 - "Tigecycline-induced Drug Fever and Leukemoid Reaction: A Case Report." 11/01/2015 - "In this study, we describe a patient in whom tigecycline-induced drug fever and leukemoid reaction (LR) after 3 weeks of therapy for pneumonia.A 62-year-old man developed aspiration pneumonia on February 1, 2015. " 06/01/2016 - "Acute Generalized Exanthematous Pustulosis Due to Labetalol; Drug Fever and Leukocytosis Caused by Tigecycline; Toxic Hepatitis Induced by Methylprednisolone Intravenous Pulse Dosing; Mitoxantrone-Related Osteonecrosis of the Jaw; Medications with Anticholinergic Effects and Their Implications in the Elderly."
8.	Carboplatin (JM8)FDA LinkGeneric 09/01/2021 - "Knowledge of carboplatin-induced drug fever may help physicians reach timely recognition for appropriate interventions." 09/01/2021 - "Younger age was found to be a risk factor for drug fever following carboplatin treatment (odds ratio = 0.126, 95% confidence interval: 0.025-0.628; p < 0.05). " 09/01/2021 - "Drug fever was observed in 25 patients (7.86%) in 45 cycles of total 1605 carboplatin-containing infusions. " 09/01/2021 - "Data for patients who experienced carboplatin-induced drug fever and those who received the same treatment but did not experience drug fever were compared for statistical significance. " 09/01/2021 - "Drug fever induced by carboplatin-based regimens: Higher incidence in a women's hospital."
9.	Heat-Shock Proteins (Heat-Shock Protein)IBA 10/29/1993 - "In conclusion, (1) methamphetamine-induced hyperthermia per se is a stressful stimulant causing neuronal induction of HSP72 in the hippocampus neurons, particularly of CA1/2 and medial CA3 sectors, but does not prove fatal to the cells; (2) there is a cell type-specific difference in response to hyperthermic insult by inducing HSP72 and the timing of the induction response in the hippocampal formation; and (3) the animals that underwent drug-induced hyperthermia may be useful as an experimental model for the study of the protective mechanism of heat shock proteins against subsequent harmful stimuli."
10.	Doxycycline (Periostat)FDA LinkGeneric 11/01/2016 - "Drug fever induced by doxycycline is rarely reported. " 11/01/2016 - "Doxycycline-induced drug fever: a case report." 11/01/2016 - "In this study, we describe a patient in whom doxycycline induced drug fever after 17 days of therapy for brucellosis. "

Therapies and Procedures

1.	Therapeutics 06/01/2022 - "A review of the medical literature identified only 5 previously published articles specific to NIT-induced drug fever, none of which specified interruptions of psychotropic therapy for a patient with acute psychiatric decompensation. " 01/01/2022 - "We also analyzed the characteristics of drug fever during anti-Helicobacter pylori therapy. " 01/01/2019 - "We also present a review of relevant literature and provide a point of reference for the clinical diagnosis and therapy of patients with drug fever." 01/01/1982 - "3) As for the side effects, elevation of S-GOT and S-GPT, and drug fever were observed in 1 case, but disappeared soon after discontinuation of the therapy." 09/06/1980 - "this drug-induced fever appeared initially 2--4 weeks after the commencement of Alival therapy. "
2.	Induced Hyperthermia (Thermotherapy) 08/01/2023 - "More than Drug Fever: Dexmedetomidine-Induced Hyperthermia in a Critically Ill Patient." 10/29/1993 - "In conclusion, (1) methamphetamine-induced hyperthermia per se is a stressful stimulant causing neuronal induction of HSP72 in the hippocampus neurons, particularly of CA1/2 and medial CA3 sectors, but does not prove fatal to the cells; (2) there is a cell type-specific difference in response to hyperthermic insult by inducing HSP72 and the timing of the induction response in the hippocampal formation; and (3) the animals that underwent drug-induced hyperthermia may be useful as an experimental model for the study of the protective mechanism of heat shock proteins against subsequent harmful stimuli." 06/01/2022 - "Differentiating probable nitrofurantoin-induced drug fever from antipsychotic-induced hyperthermia in a patient receiving clozapine."
3.	Drug Therapy (Chemotherapy) 09/01/2021 - "Drug fever is generally tolerated by patients, who insist on chemotherapy. " 09/01/2021 - "After chemotherapy rechallenge, the mean frequency of drug fever was 2 times per patient (range: 1-4 times). " 01/01/2018 - "Ten patients (23.3%) required chemotherapy treatment schedule delay, and one patient required one dose level reduction because of drug fever. " 02/01/2016 - "Drug fever after cancer chemotherapy is most commonly observed on posttreatment days 3 and 4." 09/01/2021 - "This study describes and analyzes relatively higher incidence rate of carboplatin-related drug fever associated with gynecologic cancer chemotherapy in order to allay anxiety in patients and avoid unnecessary interventions. "
4.	Critical Care (Surgical Intensive Care) 07/01/2022 - "The incidence of drug fever is even higher in critical care settings because multiple medications are being administered simultaneously. " 11/01/2015 - "Drug-induced hyperthermia in critical care." 10/03/1998 - "When encountering fever of unknown origin in intensive care patients it is always important to think of drug fever."
5.	Perioperative Period 09/01/2002 - "Drug-induced hyperthermia and rhabdomyolysis during the perioperative period: report of three patients."