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Protein Kinase D2

A SERINE-THREONINE PROTEIN KINASE that is activated in response to OXIDATIVE STRESS.

Also Known As:

D2, Protein Kinase; Enzyme, PKD2; PKD2 Enzyme; PRKD2 Protein

Networked: 26 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Protein Kinase D2: 26
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Protein Kinase D2: 26

Experts

1.	Seufferlein, Thomas: 6 articles (10/2020 - 12/2004)
2.	Azoitei, Ninel: 4 articles (10/2020 - 07/2011)
3.	Becher, Alexander: 3 articles (10/2020 - 12/2014)
4.	Brunner, Cornelia: 3 articles (10/2020 - 07/2011)
5.	Van Lint, Johan: 3 articles (01/2018 - 12/2004)
6.	Chiosis, Gabriela: 2 articles (10/2020 - 12/2014)
7.	Diepold, Kristina: 2 articles (10/2020 - 12/2014)
8.	Rouhi, Arefeh: 2 articles (10/2020 - 12/2014)
9.	Genze, Felicitas: 2 articles (12/2014 - 07/2011)
10.	Bernhart, Eva: 2 articles (07/2014 - 08/2013)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2023 - "In this study, we aimed to investigate the roles and mechanisms of protein kinase D2 (PKD2) in inflammation-induced dermal fibrosis and evaluate the therapeutic potential of PKD inhibitors in this disease. "
2.	Fibrosis (Cirrhosis) 01/01/2023 - "In this study, we aimed to investigate the roles and mechanisms of protein kinase D2 (PKD2) in inflammation-induced dermal fibrosis and evaluate the therapeutic potential of PKD inhibitors in this disease. " 01/01/2023 - "Loss of Protein Kinase D2 Activity Protects Against Bleomycin-Induced Dermal Fibrosis in Mice."
3.	Neoplasms (Cancer) 01/01/2019 - "Protein kinase D2 (PKD2) has been reported to be related with progression and invasion in various cancers. " 01/01/2018 - "Protein kinase D2: a versatile player in cancer biology." 12/01/2014 - "HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization." 01/01/2019 - "Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer." 12/01/2014 - "Protein kinase D2 (PKD2) has been demonstrated to promote tumorigenesis in many types of cancers. "
4.	Glioblastoma (Glioblastoma Multiforme) 08/01/2013 - "Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro." 07/01/2011 - "Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation." 12/01/2014 - "The kinase PRKD2 (protein kinase D) is a crucial regulator of tumor cell-endothelial cell communication in gastrointestinal tumors and glioblastomas, but its mechanistic contributions to malignant development are not understood. "
5.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2021 - "B Cell Receptor Signaling and Protein Kinase D2 Support Regulatory B Cell Function in Pancreatic Cancer." 02/01/2014 - "Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Catenins
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Mitogen-Activated Protein Kinase Kinases (MEKs)
5.	Matrix Metalloproteinases (MMPs)
6.	Nonsense Codon (Nonsense Mutation)
7.	NF-kappa B (NF-kB)
8.	Dextran Sulfate
9.	Protein Kinase C
10.	Phosphotransferases (Kinase)