Zn-Alpha-2-Glycoprotein

A soluble protein that stimulates LIPOLYSIS in ADIPOCYTES and causes the extensive fat losses associated with some advanced cancers.

Also Known As:

Alpha2 Seminoglycoprotein; Zn Alpha 2 Glycoprotein; Alpha2-Seminoglycoprotein; Glycoprotein, Zinc-Alpha(2); Zinc-Alpha(2)-Glycoprotein; Zn-Alpha(2)-GP

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Adipokines: 9534
      - Zn-Alpha-2-Glycoprotein: 7
        human AZGP1 protein
        mouse AZGP1 protein
        rat AZGP1 protein
Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Zn-Alpha-2-Glycoprotein: 7
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Adipokines: 9534
      - Zn-Alpha-2-Glycoprotein: 7
        human AZGP1 protein
        mouse AZGP1 protein
        rat AZGP1 protein
  - Glycoproteins: 24834
    - Zn-Alpha-2-Glycoprotein: 7
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Adipokines: 9534
      - Zn-Alpha-2-Glycoprotein: 7
        human AZGP1 protein
        mouse AZGP1 protein
        rat AZGP1 protein
  - Peptide Hormones: 1347
    - Adipokines: 9534
      - Zn-Alpha-2-Glycoprotein: 7
        human AZGP1 protein
        mouse AZGP1 protein
        rat AZGP1 protein
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Adipokines: 9534
    - Zn-Alpha-2-Glycoprotein: 7

Experts

1.	Russell, Steven T: 2 articles (03/2010 - 02/2004)
2.	Tisdale, Michael J: 2 articles (03/2010 - 02/2004)
3.	Akinci, O: 1 article (01/2022)
4.	Ergun, D D: 1 article (01/2022)
5.	Ergun, S: 1 article (01/2022)
6.	Simsek, G: 1 article (01/2022)
7.	Taskin, H E: 1 article (01/2022)
8.	Taskin, M: 1 article (01/2022)
9.	Uzun, H: 1 article (01/2022)
10.	Castillero, E: 1 article (04/2008)

Related Diseases

1.	Weight Loss (Weight Reduction) 01/01/2022 - "The aim of this study was to analyze serum zinc (Zn), Zn-alpha 2 glycoprotein (ZAG), peroxisome proliferator-activated receptor-γ (PPAR-γ) and nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) levels in morbidly obese patients before and after laparoscopic sleeve gastrectomy (LSG) and determine the association between alteration in body mass index (BMI), the % Excess Weight Loss (% EWL) and the biochemical parameters. "
2.	Cachexia 06/01/2005 - "Adipose tissue of mice bearing a cachexia-inducing murine tumour (MAC16) shows increased expression of zinc-alpha(2)-glycoprotein (ZAG), a lipolytic factor thought to be responsible for the increased lipolysis. " 02/06/2007 - "Zinc-alpha(2)-glycoprotein (ZAG), the sole soluble member of this superfamily has been implicated in cachexia, a poorly understood yet life-threatening, severe wasting syndrome. " 03/01/2010 - "Zinc-alpha(2)-glycoprotein (ZAG) is an adipokine associated with fat loss in cancer cachexia. " 02/27/2004 - "Loss of adipose tissue in cancer cachexia has been associated with tumour production of a lipid-mobilizing factor (LMF) which has been shown to be homologous with the plasma protein zinc-alpha(2)-glycoprotein (ZAG). "
3.	Neoplasms (Cancer) 03/01/2010 - "Zinc-alpha(2)-glycoprotein (ZAG) is an adipokine associated with fat loss in cancer cachexia. " 02/27/2004 - "Loss of adipose tissue in cancer cachexia has been associated with tumour production of a lipid-mobilizing factor (LMF) which has been shown to be homologous with the plasma protein zinc-alpha(2)-glycoprotein (ZAG). "
4.	Wasting Syndrome (Wasting Disease) 02/06/2007 - "Zinc-alpha(2)-glycoprotein (ZAG), the sole soluble member of this superfamily has been implicated in cachexia, a poorly understood yet life-threatening, severe wasting syndrome. "
5.	Necrosis 04/01/2008 - "Serum concentrations of insulin, leptin, adiponectin, glycerol and nitrites, as well as gene expression of leptin, adiponectin, hormone-sensitive lipase (HSL), fatty acid synthase (FAS), tumour necrosis factor alpha and zinc-alpha(2)-glycoprotein (ZAG) were determined. "

Related Drugs and Biologics

1.	Peroxisome Proliferator-Activated Receptors (PPAR)
2.	Zinc
3.	Fatty Acid Synthases (Fatty Acid Synthase)
4.	Adipokines
5.	Adiponectin
6.	Leptin
7.	Proteins (Proteins, Gene)
8.	Orosomucoid (Seromucoid)
9.	Nitrites
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Gastrectomy