Xenotropic and Polytropic Retrovirus Receptor

A cell surface receptor involved in G-protein recruitment and G-protein-coupled signal transduction. The receptor also plays a role in phosphate homeostasis.

Also Known As:

Protein, XPR1; Receptor, X-MLV; X MLV Receptor; Receptor, XPR1; Receptor, Xenotropic Murine Leukemia Virus; X-MLV Receptor; XPR1 Protein; XPR1 Receptor; Xenotropic Murine Leukemia Virus Receptor; Xenotropic Murine Leukemia Virus Receptors

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Xenotropic and Polytropic Retrovirus Receptor: 11
        human XPR1 protein
        mouse Xpr1 protein
      - Virus Receptors: 342
        Xenotropic and Polytropic Retrovirus Receptor: 11
        human XPR1 protein
        mouse Xpr1 protein

Experts

1.	Kozak, Christine A: 2 articles (11/2010 - 10/2007)
2.	Yan, Yuhe: 2 articles (11/2010 - 10/2007)
3.	Wang, Lin: 1 article (06/2022)
4.	Arase, Hokuto: 1 article (01/2022)
5.	Kitazono, Takanari: 1 article (01/2022)
6.	Nakano, Toshiaki: 1 article (01/2022)
7.	Taniguchi, Masatomo: 1 article (01/2022)
8.	Tokumoto, Masanori: 1 article (01/2022)
9.	Torisu, Kumiko: 1 article (01/2022)
10.	Tsuruya, Kazuhiko: 1 article (01/2022)

Related Diseases

1.	Thrombosis (Thrombus) 11/01/2021 - "In this study, xenotropic and polytropic retrovirus receptor 1 (XPR1) regulated polyphosphate in platelets and was implicated in thrombosis in vivo. "
2.	Prostatic Neoplasms (Prostate Cancer) 11/01/2010 - "We screened rodents and other mammals for sequence variation in the Xpr1 receptor for the mouse xenotropic or polytropic mouse leukemia viruses (X-MLVs or P-MLVs, respectively) of the gammaretrovirus family and for susceptibility to mouse-derived X/P-MLVs and to XMRV (xenotropic murine leukemia virus-related virus), an X-MLV-like virus isolated from humans with prostate cancer and chronic fatigue syndrome. " 07/01/2009 - "SEVI enhanced XMRV infectivity but did not bypass the requirement for the xenotropic and polytropic retrovirus receptor 1. Furthermore, XMRV RNA was detected in prostatic secretions of some men with prostate cancer. "
3.	Infections 08/18/2015 - "The results did not correlate with variation in the major MLV receptor Xpr1, which can restrict exogenous MLVs, suggesting that endogenous MLV distribution may reflect gene flow more than past resistance to infection." 09/01/2004 - "We cloned the envelope gene of this virus, inserted it into a bicistronic vector, and found that the envelope protein differs from other, similar envelope proteins that also utilize the polytropic receptor (Xpr1) in that it is severely impaired in mediating infection of human and mink cells. "
4.	Vascular Calcification 01/01/2022 - "Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification."
5.	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) 11/01/2010 - "We screened rodents and other mammals for sequence variation in the Xpr1 receptor for the mouse xenotropic or polytropic mouse leukemia viruses (X-MLVs or P-MLVs, respectively) of the gammaretrovirus family and for susceptibility to mouse-derived X/P-MLVs and to XMRV (xenotropic murine leukemia virus-related virus), an X-MLV-like virus isolated from humans with prostate cancer and chronic fatigue syndrome. "

Related Drugs and Biologics

1.	Polyphosphates
2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	RNA (Ribonucleic Acid)
5.	Cell Surface Receptors