Shelterin Complex

A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).

Also Known As:

Capping Complex, Telomeric; Complex, CST; Complex, Ctc1-Stn1-Ten1; Complex, POT1-TPP1 Shelterin; Complex, Shelterin; Complex, Telomere POT1-TPP1; Complex, Telomeric Capping; Ctc1 Stn1 Ten1 Complex; POT1 TPP1 Shelterin Complex; POT1-TPP1 Complex, Telomere; Shelterin Complex, POT1-TPP1; Telomere POT1 TPP1 Complex; Telomeric Stn1 Ten1 Capping Complex; Telosomes; CST Complex; Ctc1-Stn1-Ten1 Complex; POT1-TPP1 Shelterin Complex; Telomere Cap Complex; Telomere POT1-TPP1 Complex; Telomeric Capping Complex; Telomeric Stn1-Ten1 Capping Complex; Telosome

Networked: 70 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chai, Weihang: 5 articles (09/2021 - 12/2013)
2.	Luo, Zhenhua: 3 articles (01/2022 - 01/2020)
3.	Chastain, Megan: 3 articles (09/2021 - 01/2017)
4.	Shiva, Olga: 3 articles (09/2021 - 01/2017)
5.	Feng, Xuyang: 2 articles (01/2022 - 01/2021)
6.	Liu, Weijin: 2 articles (01/2022 - 01/2021)
7.	Wang, Yuan: 2 articles (09/2021 - 01/2018)
8.	Antonini, James M: 2 articles (01/2021 - 01/2019)
9.	Blasco, Maria A: 2 articles (01/2021 - 09/2019)
10.	Shoeb, Mohammad: 2 articles (01/2021 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Here, using bioinformatics tools, we performed a study in 33 cancer types and over 10,000 TCGA samples analyzing the role of the CST complex in cancer. " 01/01/2022 - "Pan-cancer analysis reveals that CTC1-STN1-TEN1 (CST) complex may have a key position in oncology." 10/26/2021 - "While the shelterin complex guards and coordinates the mechanism of telomere regulation, deregulation of this process is tightly linked to malignant transformation and cancer. " 07/01/2021 - "Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer." 01/01/2021 - "Pan-cancer analyses reveal regulation and clinical outcome association of the shelterin complex in cancer."
2.	Obesity 01/01/2020 - "The present study investigated the effects of obesity and aging on C57BL/6J mice adipose tissue mRNA expression of shelterin complex genes. " 01/01/2020 - "However, the effect of high-fat diet (HFD) induced obesity and advancing age on the shelterin complex and telomerase in adipose tissue is unknown. " 01/01/2020 - "High-fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue." 12/01/2018 - "Our results demonstrate that independently of comorbidities, individuals with obesity had significantly shorter telomeres, augmented expression of negative regulators of the shelterin complex, increased lipid peroxidation and higher oxidized protein levels associated with increased non-enzymatic antioxidant defenses. " 01/01/2020 - "These findings suggest obesity and age impact expression of shelterin complex and telomerase related genes in adipose, perhaps altering telomere function in adipose tissue thereby increasing inflammation and risk of chronic disease."
3.	Inflammation (Inflammations) 01/01/2018 - "In this study, we sought to address two key questions: whether telomerase is involved in inflammation in ASM cells, and whether components of the shelterin complex are also required for an inflammatory response in ASM cells. " 01/01/2020 - "These findings suggest obesity and age impact expression of shelterin complex and telomerase related genes in adipose, perhaps altering telomere function in adipose tissue thereby increasing inflammation and risk of chronic disease."
4.	Genomic Instability 01/01/2023 - "Collectively, our results suggest that the CST complex is required for maintaining genomic stability in response to oxidative DNA damage, possibly through RAD51-dependent DNA repair/protection mechanisms." 01/01/2022 - "The CTC1-STN1-TEN1 (CST) complex plays a crucial role in telomere replication and genome stability. " 01/01/2021 - "The telomere-bound shelterin complex is essential for chromosome-end protection and genomic stability. " 01/01/2021 - "Finally, we uncover that CST complex inactivation exacerbates genome instability in BRCA2 deficient cells. " 01/01/2019 - "The human CST complex (CTC1-STN1-TEN1) is associated with telomere functions including genome stability. "
5.	Carcinogenesis 04/01/2017 - "Here, we aimed to analyze whether shelterin complex gene expression and telomere length variation, play any role in gallbladder carcinogenesis. " 04/01/2017 - "Telomere length variation and expression analysis of shelterin complex genes during gallbladder carcinogenesis." 12/15/2015 - "Future work is needed to characterize the role of the CST complex in gliomagenesis and further elucidate the complex balance between ageing, telomere length, and molecular carcinogenesis. " 09/27/2019 - "Direct disruption of the shelterin complex through TRF1 inhibition can block tumorigenesis in cancer mouse models by a mechanism that involves DNA damage induction and reduction of proliferation and stemness. " 03/15/2016 - "It suggests that the decreased protein levels of the shelterin complex and the shortened telomere length contribute to the tumorigenesis of MGC and BCC. "

Related Drugs and Biologics

1.	Telomerase (Telomerase Reverse Transcriptase)
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	DNA (Deoxyribonucleic Acid)
5.	Carrier Proteins (Binding Protein)
6.	Biomarkers (Surrogate Marker)
7.	Shelterin Complex
8.	Catenins
9.	Proteasome Endopeptidase Complex (Proteasome)
10.	F-Box Proteins

Related Therapies and Procedures

1.	Therapeutics